9783527321094

Acetylsalicylic Acid

by ;
  • ISBN13:

    9783527321094

  • ISBN10:

    3527321098

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2009-01-20
  • Publisher: Wiley-Blackwell

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Summary

Written by a leading expert on Aspirin-related research, this is the first comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever.The text is written with a wide audience in mind and to be readily understandable for clinicians as well as biomedical researchers and pharmacologists alike. The content is up to date and includes the latest results of clinical and academic research, with a balanced view on the disputed properties of this famous drug. Key Features: A must-have for everyone working with Aspirin. An invaluable compendium for clinicians and biomedical researchers on one of the most successful drugs in history. Written by one of the leading experts on the drug with more than 350 publications. First comprehensive treaty of the history, pharmacological effects and clinical applications of this famous drug.

Author Biography

Prof. Karsten Schror, MD
Institut fur Pharmakologie und Klinische Pharmakologie
Heinrich-Heine-Universitat
Dusseldorf

CURRICULUM VITAE (May, 2008)

Date of birth: May 3, 1942

Place of birth: Oldenburg

Marital status: married

Education:
1961 - 1967 Medicine, Universitat Halle/Wittenberg
1967 - 1972 Pharmacology, Universitat Halle/Wittenberg

MD Thesis: Effects of variations in external Ca++- and K+-concentrations on sympathetic nerve stimulation (Department of Physiology, Universitat Halle/Wittenberg, 1970)

Wellcome Research Laboratories (UK); Supervisor: Sir John R. Vane, 1976 - 1977; Department of Physiology, Jefferson Medical College, Philadelphia (USA); Supervisor: Prof. A.M. Lefer, 1977; Visiting Professor at the Medical University of South Carolina at Charleston (USA) (Prof. P.V. Halushka), 1993 - 1994; Visiting Professor at the Department of Internal Medicine, Division of Hematology

Table of Contents

Prefacep. XI
General Aspectsp. 3
Historyp. 5
Willow Bark and Leaves as Antipyretic, Anti-Inflammatory Analgesicsp. 5
Salicylates as the Active Ingredient of Willow Bark and Other Natural Sourcesp. 6
Synthesis of Acetylsalicylic Acid and First Clinical Studiesp. 7
Mode of Aspirin Actionp. 12
Anti-Inflammatory/Analgesic Actions of Aspirinp. 14
Aspirin in the Cardiovascular Systemp. 15
Current Research Topicsp. 17
Chemistryp. 25
Structures and Chemical Properties of Salicylatesp. 25
Salicylates in Clinical Usep. 25
Aspirin Formulationsp. 27
Determination of Salicylatesp. 30
Gas-Liquid Chromatographyp. 30
High-Performance Liquid Chromatographyp. 30
Spectrophotometryp. 30
Pharmacologyp. 33
Pharmacokineticsp. 35
Absorption and Distributionp. 36
Absorptionp. 36
Particular Aspirin Formulationsp. 40
Distributionp. 40
Modifying Factorsp. 42
Biotransformation and Excretionp. 46
Biotransformation of Aspirinp. 46
Biotransformations of Salicylic Acidp. 48
Excretion of Salicylatesp. 49
Modification of Biotransformations and Excretion of Salicylatesp. 50
Cellular Modes of Actionp. 53
Inhibition of Cyclooxygenasesp. 54
Acetylation of Cyclooxygenases and Traditional NSAIDsp. 55
Modulation of COX-2 Gene Expressionp. 61
Further Actions of Salicylates on Arachidonate Metabolismp. 62
COX-Independent Actions on Cell Functionp. 66
Kinasesp. 67
Transcription Factorsp. 69
Oxidative Stress and Nitric Oxidep. 73
Immune Responsesp. 75
Energy Metabolismp. 79
Fatty Acid -Oxidationp. 80
Uncoupling of Oxidative Phosphorylationp. 82
Toxic Actions of Salicylates on the Liverp. 84
Actions on Organs and Tissuesp. 88
Hemostasis and Thrombosisp. 89
Plateletsp. 90
Endothelial Cellsp. 95
Plasmatic Coagulationp. 98
Fibrinolysisp. 98
Inflammation, Pain, and Feverp. 105
Inflammationp. 106
Painp. 110
Feverp. 113
Aspirin and Malignanciesp. 120
COX-Related Antitumor Effects of Aspirinp. 120
Nonprostaglandin-Related Antitumor Actions of Aspirinp. 122
Nonspecific Actions of Salicylatesp. 124
Toxicity and Drug Safetyp. 129
Systemic Side Effectsp. 131
Acute and Chronic Toxicityp. 132
Occurrence and Symptomsp. 132
Treatmentp. 136
Habituationp. 139
Bleeding Disordersp. 142
Prolongation of Bleeding Time by Aspirinp. 142
Aspirin-Related Bleeding Risk in Surgical Interventionsp. 144
Aspirin, Other Drugs, and Alcoholp. 146
Prevention and Treatment of Bleedingsp. 146
Safety Pharmacology in Particular Life Situationsp. 150
Pregnancy and Fetal Developmentp. 150
The Elderly Patientp. 153
Organ Toxicityp. 157
Gastrointestinal Tractp. 157
Pathophysiology of GI Injuryp. 158
Prostaglandins and Gastric Mucosal Protectionp. 160
Mode of Aspirin Actionp. 161
Helicobacter pylorip. 164
Clinical Studiesp. 166
Aspirin and Other Drugsp. 170
Kidneyp. 179
Analgesic Nephropathyp. 179
Mode of Aspirin Actionp. 180
Clinical Studiesp. 181
Liverp. 187
Drug-Induced Liver Injuryp. 187
Mechanisms of Aspirin Actionp. 187
Aspirin and Other Drugsp. 188
Audiovestibular Systemp. 191
Pathophysiology of Hearing and Equilibrium Disturbancesp. 191
Mode of Aspirin Actionp. 191
Aspirin, Arachidonic Acid, and Prostaglandinsp. 193
Clinical Trialsp. 193
Non-Dose-Related (Pseudo)allergic Actions of Aspirinp. 197
Aspirin Hypersensitivity (Widal's Syndrome)p. 197
Pathophysiology and Clinicsp. 197
Mode of Aspirin Actionp. 199
Clinical Trialsp. 201
Urticaria/Angioedema, Stevens-Johnson and Lyell Syndromesp. 205
Urticaria/Angioedemap. 205
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (Lyell Syndrome)p. 206
Reye's Syndromep. 208
Clinics, Laboratory, and Morphological Findingsp. 209
Etiologyp. 209
Clinical Studiesp. 212
Actual Situationp. 217
Clinical Applications of Aspirinp. 223
Thromboembolic Diseasesp. 227
Coronary Vascular Diseasep. 228
Thrombotic Risk and Mode of Aspirin Actionp. 229
Clinical Trials: Primary Prevention in Individuals Without Risk Factorsp. 231
Clinical Trials: Primary Prevention in Individuals with Risk Factorsp. 235
Clinical Trials: Stable Angina Pectorisp. 237
Clinical Trials: Secondary Preventionp. 238
Clinical Trials: Percutaneous Coronary Interventionsp. 243
Clinical Trials: Coronary Artery Bypass Graft Surgery (CABG)p. 244
Aspirin and Other Drugsp. 246
Actual Situationp. 250
Cerebrovascular Diseasesp. 260
Thrombotic Risk and Mode of Aspirin Actionp. 261
Clinical Trials: Primary Preventionp. 263
Clinical Trials: Secondary Preventionp. 265
Aspirin and Other Drugsp. 267
Actual Situationp. 270
Peripheral Arterial Diseasep. 276
Thrombotic Risk and Mode of Aspirin Actionp. 276
Clinical Trials: Primary Preventionp. 278
Clinical Trials: Secondary Preventionp. 279
Clinical Trials: Peripheral Transluminal Angioplasty (PTA)p. 281
Aspirin and Other Drugsp. 282
Actual Situationp. 283
Venous Thrombosisp. 287
Thrombotic Risk and Mode of Aspirin Actionp. 287
Clinical Trialsp. 287
Actual Situationp. 288
Preeclampsiap. 290
Thrombotic Risk and Mode of Aspirin Actionp. 290
Clinical Trialsp. 293
Clinical Trials in Pregnancy-Induced Hypertension: Reasons for Data Variabilityp. 294
Actual Situationp. 298
Aspirin "Resistance"p. 303
Definition and Types of Pharmacological Aspirin "Resistance"p. 304
Detection of Aspirin "Resistance"p. 304
Pharmacological Mechanisms of Aspirin "Resistance"p. 307
Clinical Trialsp. 310
Pain, Fever, and Inflammatory Diseasesp. 322
Aspirin as an Antipyretic Analgesicp. 322
Fever, Pain, and Antipyretic/Analgesic Actions of Aspirinp. 323
Clinical Trialsp. 326
Aspirin and Other Drugsp. 327
Actual Situationp. 328
Arthritis and Rheumatismp. 332
Pathophysiology and Mode of Aspirin Actionp. 332
Clinical Trialsp. 334
Aspirin and Other Drugsp. 335
Actual Situationp. 336
Kawasaki Diseasep. 339
Pathophysiology and Mode of Aspirin Actionp. 339
Clinical Trialsp. 340
Aspirin and Other Drugsp. 341
Actual Situationp. 341
Further Clinical Indicationsp. 343
Colorectal Cancerp. 343
Etiology and Pathophysiology of Intestinal Adenomas, Colorectal Cancer, and Mode of Aspirin Actionp. 344
Clinical Trials: Epidemiological Studiesp. 346
Clinical Trials: Randomized Prospective Prevention Trialsp. 349
Aspirin and Other Drugsp. 352
Actual Situationp. 352
Alzheimer's Diseasep. 359
Pathophysiology and Mode of Aspirin Actionp. 359
Clinical Trialsp. 361
Aspirin and Other Drugsp. 363
Actual Situationp. 363
p. 367
p. 369
Indexp. 371
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