Acute Liver Failure

by Edited by William M. Lee , Roger Williams , Foreword by Jean-Pierre Benhamou , Jacques Bernuau

• ISBN13: 9780521188944
• ISBN10: 0521188946
• Edition: Revised
• Format: Paperback
• Copyright: 2011-06-02
• Publisher: Cambridge University Press

Summary

Acute liver failure (ALF), or fulminant hepatic failure, is a distinct clinical syndrome that crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention. With the advent of transplantation, the importance of understanding management of ALF has taken on a new urgency. In this first volume dedicated to ALF, the editors bring together a distinguished team of contributors to describe the etiology, pathology and treatment of this important syndrome. Also covered are consensus techniques in liver transplantation for ALF patients, as well as descriptions of artificial and bioartificial liver assist devices. A section on future treatments includes hepatocyte transplantation, auxiliary grafts and other temporary liver support. Notable for the high level of the authors' expertise, this comprehensive volume should prove invaluable.

Table of Contents

Clinical Syndrome and Etiology:

Classification and clinical syndromes of Acute Liver Failure

Viral hepatitis and Acute Liver Failure

Drug hepatoxicity and Acute Liver Failure

Acetaminophen-related Acute Liver Failure

Unusual causes of Acute Liver Failure

Pediatric aspects of Acute Liver Failure

Mechanisms of Disease and Multisystem Involvement:

The role of cytokines and immune mechanisms in Acute Liver Failure

The pathology of Acute Liver Failure

Hepatic replication and liver regeneration

Intensive Care Management

Medical management of Acute Liver Failure

Circulatory derangements: monitoring and management of heart, kidney and brain

Brain edema and intracranial hypertension in Acute Liver Failure

Management of infection in Acute Liver Failure

Transplantation:

Prognosis and consideration of transplantation

Liver transplantation in patients with Acute Liver Failure: the European experience

Liver transplantation in patients with Acute Liver Failure: the American experience

Auxiliary liver transplantation

Artificial and Bioartifical Liver Devices:

Extracorporeal liver support: historical background and critical analysis

Hepatocyte culture and bioreactor design for liver support systems

Clinical experience with an extracorporeal liver assist device (ELAD)

Other Approaches:

Treatment of Acute Liver Failure by high volume plasmapheresis

Dialysis/adsorption techniques for Acute Liver Failure

Hepatocyte transplantation in liver failure and inherited metabolic disorders

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