Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases

by Hasko; Gyorgy

• ISBN13: 9780849339998
• ISBN10: 0849339995
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-07-20
• Publisher: CRC Press

Summary

An overview of how adenosine and inosine regulate immune responses, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases covers aspects of molecular biology, cell biology, and pharmacology. It addresses the role of adenosine receptors in regulating the function of various cell types involved in immune responses. It features data derived from studies using cutting-edge techniques. It discusses disease states such as autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. With contributions from international experts, the text is ideal for researchers in pharmaceutical companies, academic scientists, and clinicians

Table of Contents

Adenosine receptor pharmacology	p. 1
Medicinal chemistry of adenosine A[subscript 3] receptors	p. 15
The role of CD73 in the generation of extracellular adenosine for adenosine receptor signaling	p. 39
Regulation of monocyte/macrophage function by adenosine receptors	p. 49
Impaired lymphocyte activation in the presence of adenosine : mechanisms and physiologic relevance	p. 69
Adenosine and neutrophil functions	p. 89
Dendritic cells regulated by nucleotides and nucleosides	p. 101
Adenosine and endothelia cell function	p. 109
Adenosine A[subscript 2B] receptor in the intestinal epithelia	p. 131
Adenosine, adenosine receptors, and the regulation of glial cells in neuronal damage	p. 145
Adenosine receptors, wound healing, and angiogenesis	p. 157
A[subscript 2A] adenosine receptors and ischemia reperfusion injury	p. 165
Adenosine signaling in chronic lung disease	p. 187
Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders	p. 213
Anti-inflammatory and cytoprotective effects of inosine	p. 237
Adenosine and infection	p. 257
Regulation of peripheral inflammation by spinal adenosine	p. 285
Adenosine, tumors, and immunity	p. 299
Adenosine in atherosclerosis	p. 313
Regulation of macrophage-dependent angiogenesis by adenosine and toll-like receptors	p. 325
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