9780120224715

Advances in Immunology

by
  • ISBN13:

    9780120224715

  • ISBN10:

    0120224712

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 1998-12-18
  • Publisher: Elsevier Science
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Summary

KEY TOPICS: Ig A Deficiency The Role of Cellular Immunity in Protection against HIV Infection Mouse Mammary Tumour Virus: Immunological Interplays between Virus and Host The Transporter Associated with Antigen Processing NF-kB in cytokine gene expression NF-kB as a target for immunosuppressive and anti-inflammatory molecules Key Features* A Deficiency* The Role of Cellular Immunity in Protection against HIV Infection* Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host* The Transporter Associated with Antigen Processing* NF-kB in cytokine gene expression* NF-kB as a target for immunosuppressive and anti-inflammatory molecules

Table of Contents

Contributors ix
αβ/γδ Lineage Commitment in the Thymus of Normal and Genetically Manipulated Mice
Hans Jorg Fehling
Susan Gilfillan
Rhodri Ceredig
Introduction
1(15)
Models of αβ/γδ Lineage Commitment and Lineage Maintenance
16(3)
Analysis of TCR Gene Rearrangements in αβ and γδ Lineage Cells
19(16)
Analysis of TCR Transgenic and Gene-Targeted Mice
35(17)
Cell Culture Studies
52(1)
Developmental Considerations
53(1)
In Search of a Consensus Model for the αβ/γδ Lineage Split
54(23)
References
64(13)
Immunoregulatory Functions of γδ T Cells
Willi Born
Carol Cady
Jessica Jones-Carson
Akiko Mukasa
Michael Lahn
Rebecca O'Brien
Introduction
77(1)
Origin, Lineage and Development, and Distribution
78(5)
Specificity
83(10)
Functions
93(30)
Concluding Remarks
123(22)
References
124(21)
STATs as Mediators of Cytokine-Induced Responses
Timothy Hoey
Michael J. Grusby
Introduction
145(1)
The STAT Gene Family
145(1)
Structural and Functional Domains in STAT Proteins
146(6)
STAT-Deficient Mice
152(3)
STAT Function in Cellular Proliferation and Disease
155(1)
Regulation of STAT Function
156(1)
Summary and Perspective
157(6)
References
158(5)
CD95(APO-1/Fas)-Mediated Apoptosis: Live and Let Die
Peter H. Krammer
Introduction
163(1)
Death Receptors and Ligands
164(2)
The CD95/CD95L System
166(1)
Gene Defects in the CD95/CD95L System
167(1)
Role of the CD95/CD95L System in Deletion of Peripheral T Cells
168(1)
Role of the CD95/CD95L System in Liver Homeostasis
169(1)
Signal Transduction of CD95-Mediated Apoptosis
169(1)
The Death Domain
170(1)
CD95 Associated Signaling Molecules
170(2)
Other Signaling Molecules Invoked in CD95 Signaling
172(1)
Proteins of the Bcl-2 Family
172(2)
The Death-Inducing Signaling Complex (DISC)
174(2)
Downstream Caspases in CD95 Death Receptor Signaling
176(4)
Type I and Type II Cells
180(1)
FLIPs (FLICE Inhibitory Proteins)
181(1)
Sensitivity and Resistance of T Lymphocytes toward CD95-Mediated Apoptosis
182(2)
The CD95 System and Chemotherapy
184(4)
The CD95 Death System in AIDS
188(2)
Further Considerations on the Role of Apoptosis in the Clinic
190(21)
References
192(19)
A CXC Chemokine SDF-1/PBSF: A Ligand for a HIV Coreceptor, CXCR4
Takashi Nagasawa
Kazunobu Tachibana
Kenji Kawabata
Introduction
211(1)
Identification, Structure, and Expression of CXC Chemokine SDF-1/PBSF
212(3)
Physiological Functions of SDF-1/PBSF
215(2)
A SDF-1/PBSF Receptor, CXCR4
217(2)
HIV-1 Infection and CXCR4
219(3)
Perspectives
222(7)
References
222(7)
T Lymphocyte Tolerance: From Thymic Delection to Peripheral Control Mechanisms
Brigitta Stockinger
Introduction
229(1)
Central Tolerance Induction in the Thymus
229(11)
Peripheral Tolerance
240(27)
References
251(16)
Confrontation between Intracellular Bacteria and the Immune System
Ulrich E. Schaible
Helen L. Collins
Stefan H. E. Kaufmann
Introduction
267(1)
What Is an Intracellular Pathogen?
268(1)
How to Enter the Host Cell Is How to Survive
269(4)
Induction of Nonspecific Immunity
273(10)
Phagosome Maturation and Microbial Detours
283(9)
Antigen Processing and Presentation Pathways
292(15)
T-Cell Subsets and Effector Mechanisms
307(15)
Host Genetics Influencing the Outcome of Infection
322(4)
Immune Intervention Strategies
326(53)
References
336(43)
Index 379(6)
Contents of Recent Volumes 385

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