9780123737069

AID for Immunoglobulin Diversity

by
  • ISBN13:

    9780123737069

  • ISBN10:

    0123737060

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2007-06-05
  • Publisher: Elsevier Science
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Summary

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

Contributorsp. ix
Prefacep. xiii
Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory
Abstractp. 1
Introductionp. 2
Identification of AID as a Key Molecule in CSR and SHMp. 4
AID Is the Only B-Cell-Specific Factor Required for Both CSR and SHMp. 87
Functional Domains of AIDp. 11
AID Is Involved in a DNA Cleavage Stepp. 14
Major Hypotheses for the Action of AIDp. 16
Critical Examination of the DNA Deamination Modelp. 19
Evidence for a Novel Function of UNG in CSRp. 24
Conclusionp. 28
Referencesp. 29
DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives
Abstractp. 37
Introductionp. 38
AID: The DNA Deaminase Trigger for Antibody Diversificationp. 38
The Zn-Dependent Deaminase Superfamilyp. 39
Timeline of AID/APOBEC Evolutionp. 48
APOBEC1: An RNA-Editing Enzyme That Can Also Act on DNAp. 49
APOBEC2: A Muscle-Specific Family Member of Unknown Function/Activityp. 50
APOBEC4: A Distant or Ancestral Member of the AID/APOBEC Familyp. 51
APOBEC3s: DNA Deaminases Active in Viral Restrictionp. 52
Conclusionp. 63
Referencesp. 63
The Role of Activation-Induced Deaminase in Antibody Diversification and Chromosome Translocations
Abstractp. 75
Introductionp. 76
Events Preceding the DNA Lesionp. 77
The DNA Lesionp. 78
DNA Damage Detection and Resolution During CSRp. 85
AID and Lymphomagenic Lesionsp. 93
Conclusions and Perspectivesp. 96
Referencesp. 96
Targeting of AID-Mediated Sequence Diversification by cis-Acting Determinants
Abstractp. 109
Introductionp. 109
The Link Between Transcription and AID-Mediated Sequence Diversificationp. 111
Other cis-Acting Determinants Involved in the Targeting of AIDp. 116
Future Outlookp. 120
Referencesp. 120
AID-Initiated Purposeful Mutations in Immunoglobulin Genes
Abstractp. 127
Introductionp. 128
Biochemical Basis of C Deamination by APOBEC Enzymesp. 132
How and Why Might AID-Specific Mutations Be Targeted?p. 141
Selection of AID-Induced Mutations During Ab Maturationp. 143
Referencesp. 149
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
Abstractp. 157
Overview of Genetic Alterations in B Lymphocytesp. 158
Activation-Induced Cytidine Deaminasep. 162
Role of Germ Line Transcription and Switch Regions in CSRp. 169
Posttranscriptional Regulation of AIDp. 180
Mechanisms Involved in Synapsis of AID Initiated DSBs in Widely Separated S Regionsp. 184
General DNA Repair Systems in the Joining Phase of CSRp. 189
Evolution of CSRp. 197
Referencesp. 198
Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection
Abstractp. 215
Introductionp. 215
Evolution of the AID/APOBEC Cytidine Deaminase Familyp. 216
APOBEC3: A Subfamily of Antiviral Cytidine Deaminasesp. 217
AID in the Host Response to Viral Infectionp. 229
Concluding Remarksp. 235
Referencesp. 237
Role of AID in Tumorigenesis
Abstractp. 245
Introductionp. 246
AID Transgenic Mouse Modelsp. 247
Role of AID in Chromosomal Translocation and Subsequent Lymphomagenesisp. 249
AID Expression in Human B-Cell Malignanciesp. 252
Mechanism of AID Expression in Normal and Malignant B Cellsp. 259
AID Expression in Normal and Malignant Nonlymphoid Cellsp. 263
Concluding Remarksp. 265
Referencesp. 265
Pathophysiology of B-Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies
Abstractp. 275
Introductionp. 276
Ig-CSR Deficiency Type 1 Caused by Activation-Induced Cytidine Deaminase Deficiencyp. 279
Ig-CSR Deficiency Type 2 Caused by UNG Deficiencyp. 289
Molecularly Undefined Ig-CSR Deficiency with Normal SHMp. 292
Concluding Remarksp. 296
Referencesp. 298
Indexp. 307
Contents of Recent Volumesp. 317
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