9780444500953

Analytical Determination of Nicotine and Related Compounds and their Metabolites

by ;
  • ISBN13:

    9780444500953

  • ISBN10:

    0444500952

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 1999-11-02
  • Publisher: Elsevier Science
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Summary

This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.

Table of Contents

Foreword v
Neal L. Benowitz
List of Contributors ix
Pharmacological Significance of Nicotine
1(12)
Edward F. Domino
Biosynthesis of Nicotine and Related Compounds
13(32)
Lowell Bush
Walter Hempfling
Harold Burton
Biotransformation of Nicotine in Mammalian Systems
45(24)
John W. Gorrod
Georg Schepers
Chemical Properties of Nicotine and Other Tobacco-Related Compounds
69(80)
Peter A. Crooks
The Physical Chemistry of Nicotine
149(42)
Joseph Banyasz
Use of Gas Chromatographic and Mass Spectrometric Techniques for the Determination of Nicotine and its Metabolites
191(34)
Peyton Jacob, III
Gary D. Byrd
Use of High-Performance Liquid Chromatographic-Mass Spectrometric (LC-MS) Techniques for the Determination of Nicotine and its Metabolites
225(40)
Peter A. Crooks
Gary D. Byrd
Use of Immunoassay Techniques for the Determination of Nicotine and its Metabolites
265(20)
John J. Langone
Hilda B. Gjika
Helen Van Vunakis
Determination of Nicotine in Tobacco, Tobacco Processing Environments and Tobacco Products
285(108)
Michael F. Borgerding
Thomas A. Perfetti
Suresh Ralapati
Determination of Nicotine in Pharmaceutical Products and Dietary Sources
393(28)
Donald E. Leyden
Erich Leitner
Barbara Siegmund
Nitrosamines Derived from Nicotine and Other Tobacco Alkaloids
421(68)
Stephen S. Hecht
Anthony R. Tricker
Determination of Nicotine in Mainstream and Sidestream Cigarette Smoke
489(42)
Klaus Rustemeier
Jean-Jacques Piade
Nicotine in Environmental Tobacco Smoke
531(52)
Michael W. Ogden
Roger A. Jenkins
Determination of Nicotine and its Metabolites in Biological Fluids: in vivo Studies
583(62)
Riley A. Davis
Margareta Curvall
Determination of Nicotine and its Metabolites in Biological Fluids: in vitro Studies
645(24)
Mui C. Tsai
John W. Gorrod
Uses and Abuses of Cotinine as a Marker of Tobacco Smoke Exposure
669(52)
Peter N. Lee
Subject Index 721

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