Animal Models of Diabetes : A Primer

by Shafrir; Eleazar

• ISBN13: 9789058230966
• ISBN10: 9058230961
• Format: Hardcover
• Copyright: 2000-12-21
• Publisher: CRC

Summary

Animal Models of Diabetes: A Primer introduces characteristics of the most commonly used animal species with various diabetic syndromes which have been developed and extensively investigated during the last few decades. It includes animal models that are readily available, well described and proven to be of value in the research of both types of diabetes. Extensively referenced, this book will be of value to new and established investigators, graduate students and pharmaceutical scientists working on the development of antidiabetic and preventative modalities in various areas of diabetes and its complications.

Table of Contents

Preface to the Series	vii
Preface	ix
Contributors	xi
Autoimmune Diabetes Mellitus in the BB Rat	1	(42)
John P. Mordes
Rita Bortell
Herman Groen
Dennis Guberski
Aldo A. Rossini
Dale L. Greiner
The NOD Mouse and its Related Strains	43	(20)
Hiroshi Ikegami
Susumu Makino
Obesity/Diabetes in Mice with Mutations in the Leptin or Leptin Receptor Genes	63	(46)
Lieselotte Herberg
Edward H. Leiter
The Zucker Diabetic Fatty (ZDF) Rat	109	(20)
Richard G. Peterson
KK and KKAy Mice	129	(14)
Shigehisa Taketomi
Hitoshi Ikeda
The Obese Spontaneously Hypertensive Rat (SHROB, Koletsky Rat): A Model of Metabolic Syndrome X	143	(16)
Richard J. Koletsky
Jacob E. Friedman
Paul Ernsberger
Characteristics of Wistar Fatty Rat	159	(12)
Hiroyuki Odaka
Yasuo Sugiyama
Hitoshi Ikeda
The New Zealand Obese Mouse: A Polygenic Model of Type 2 Diabetes	171	(14)
Sofianos Andrikopoulos
Anne W. Thorburn
Joseph Proietto
The NSY Mouse: An Animal Model of Human Type 2 Diabetes Mellitus with Polygenic Inheritance	185	(12)
Hironori Ueda
Hiroshi Ikegami
Masao Shibata
Toshio Ogihara
The Goto-Kakizaki Rat	197	(16)
Claes-Goran Ostenson
The OLETF Rat	213	(14)
Kazuya Kawano
Tsukasa Hirashima
Shigehito Mori
Zhi-wei Man
Takashi Natori
The JCR: LA-cp Rat: An Animal Model of Obesity and Insulin Resistance with Spontaneous Cardiovascular Disease	227	(20)
J.C. Russell
S.E. Graham
The Neonatally Streptozotocin-Induced (n-STZ) Diabetic Rats, a Family of NIDDM Models	247	(26)
Bernard Portha
M.H. Giroix
P. Serradas
J. Movassat
D. Bailbe
M. Kergoat
Galactosemic Animal Models	273	(36)
W. Gerald Robison Jr.
The Rhesus Monkey (Macaca mulatta): A Unique and Valuable Model for the Study of Spontaneous Diabetes Mellitus and Associated Conditions	309	(18)
Noni L. Bodkin
Psammomys obesus: Primary Insulin Resistance Leading to Nutritionally Induced Type 2 Diabetes	327	(16)
Ehud Ziv
Rony Kalman
The C57BL/6J Mouse as a Model of Diet-Induced Type 2 Diabetes and Obesity	343	(14)
Ann E. Petro
Richard S. Surwit
Index	357