Antimicrobial Resistance in the Environment

by Keen, Patricia L.; Montforts, Mark H. M. M.

• ISBN13: 9780470905425
• ISBN10: 0470905425
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-01-24
• Publisher: Wiley-Blackwell

Summary

This book explores the role that environmental distribution of antimicrobial resistance genes and antibiotics plays in ecosystem and human health. The text features a multi-disciplinary framework that connects microbiology, environmental toxicology, and chemistry to assess human and ecological risk associated with exposure to antibiotics or antibiotic resistance genes as environmental contaminants. It also considers alternate uses and functions for antimicrobial compounds other than those intended for medicinal purposes in humans, animals, and fish. Recognizing the connectivity between overlapping complex systems, the book discusses the subject from the perspective of an ecosystem approach.

Author Biography

Patricia Lynn Keen, Ph.D. received her doctorate in Resource Management Environmental Studies from the University of British Columbia. 

Mark H.M.M. Montforts, Ph.D. is a Senior Policy Officer and Project Leader with The National Institute for Public Health and the Environment in The Netherlands.  He is also a member of many other organizations such as the Dutch Biocides Expertise Network, the Working Group on Ecotoxicology of the EU Committee for Human Medicinal Products (CHMP) at the European Medicines Agency (EMEA), and the Scientific Advisory Board of the National Asthma Foundation.

Table of Contents

Preface	p. xi
Contributors	p. xv
Sources	p. 1
Introduction	p. 3
Path to Resistance	p. 7
Antibiotic Resistome: A Framework Linking the Clinic and the Environment	p. 15
Ecological and Clinical Consequences of Antibiotic Subsistence by Environmental Microbes	p. 29
Importance of Adaptive and Stepwise Changes in the Rise and Spread of Antimicrobial Resistance	p. 43
Environmental Reservoirs of Resistance Genes in Antibiotic-Producing Bacteria and Their Possible Impact on the Evolution of Antibiotic Resistance	p. 73
Mechanisms of Bacterial Antibiotic Resistance and Lessons Learned from Environmental Tetracycline-Resistant Bacteria	p. 93
Environmental Antibiotic Resistome: New Insights from Culture-Independent Approaches	p. 123
Fatr	p. 149
Environmental Pollution by Antibiotic Resistance Genes 151	p. 151
Quantifying Anthropogenic Impacts on Environmental Reservoirs of Antibiotic Resistance	p. 173
Antibiotic Resistance in Swine-Manure-Impacted Environments	p. 203
Antimicrobial-Resistant Indicator Bacteria in Manure and the Tracking of Indicator Resistance Genes	p. 225
Municipal Wastewater as a Reservoir of Antibiotic Resistance	p. 241
Strategies to Assess and Minimize the Biological Risk of Antibiotic Resistance in the Environment	p. 251
Antibiotic Resistance in Animals-The Australian Perspective	p. 251
Antimicrobial Substances and Resistance	p. 291
Detection and Occurrence of Antibiotics and Their Metabolites in Pig Manure in Bavaria (Germany)	p. 293
Fate and Transport of Antibiotics in Soil Systems	p. 309
Antibiotics in the Aquatic Environment	p. 325
Residues of Veterinary Drugs in Wild Fish	p. 337
Role of Quaternary Ammonium Compounds on Antimicrobial Resistance in the Environment	p. 349
Effects and Risks	p. 389
Human Health Importance of use of Antimicrobials in Animals and Its Selection of Antimicrobial Resistance	p. 391
Antimicrobial Resistance Associated with Salmonid Farming	p. 423
Effect of Veterinary Medicines Introduced via Manure into Soil on the Abundance and Diversity of Antibiotic Resistance Genes on Their Transferability	p. 453
Tracking Antibiotics and Antibiotic Resistance Genes through the Composting Process and Field Distribution of Poultry Waste: Lessons Learned	p. 465
Environmental Microbial Communities Living Under Very High Antibiotic Selection Pressure	p. 483
Antibiotic Use During an Influenza Pandemic: Downstream Ecological Effects and Antibiotic Resistance	p. 503
Use of Veterinary Antibacterial Agents in Europe and the United States	p. 539
Regulatory Research on Antimicrobial Resistance in the Environment	p. 549
Index	p. 569
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