9780566083860

Ashgate Handbook of Cardiovascular Agents

by ;
  • ISBN13:

    9780566083860

  • ISBN10:

    0566083868

  • Format: Hardcover
  • Copyright: 2001-01-01
  • Publisher: WILEY

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Summary

The cardiovascular system serves to carry essential compounds to the tissues and to remove metabolic by-products. It also plays an important role in maintaining homeostasis, and functions directly or indirectly in the regulation of body temperature, oxygen supply, nutrient distribution, water and electrolyte balance, and endocrine activity. Consisting of a pump, connecting tubes, exchange membranes and blood, this system is governed by a diverse and complex array of regulatory mechanisms, encompassing central neural, autonomic, endocrine, paracrine, and autocrine control. Drugs used in the treatment of cardiovascular disease are disseminated widely in western industrialized countries. In the US alone, nearly $18 billion was spent on drugs for the treatment of cardiovascular disease and stroke in 1999. This Handbook contains records for all the major drugs that directly affect the cardiovascular system. Monographs are provided for over 1900 cardiovascular agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number; and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

Author Biography

G W A Milne was a Senior Researcher at the National Institutes of Health in Bethesda, MD, USA for 35 years where he worked on the use of spectroscopy for structure determination of organic compounds, and on molecular modeling in the design of drugs for the treatment of cancer and AIDS. He has been active for many years in the fields of chemical information and chemical computation and is the Editor of the American Chemical Society’s Journal of Chemical Information and Computer Science; Gardner’s Chemical Synonyms and Trade Names, Eleventh Edition (Ashgate); and Drugs: Synonyms and Properties (Ashgate).

E J Zeman received her PhD in physical chemistry from Northwestern University and completed a post-doctoral fellowship in computational chemistry at the University of Pittsburgh. She has worked in science publishing for over 12 years and has been on the staff of several peer-reviewed scientific journals. Dr Zeman has also written for and edited magazines, monographs, encyclopedias and reference books.

Table of Contents

Preface ix
Acknowledgements xi
How to Use This Book xiii
Glossary of Units xvii
Abbreviations and Symbols xix
PART I MAIN ENTRIES
Vasoactive Agents
3(13)
ACE Inhibitors
3(9)
Angiotensin II Antagonists
12(2)
Bradykinin Antagonists
14(1)
Protease Inhibitors
15(1)
Antihypertensive Agents
16(142)
ACE Inhibitors
16(1)
alpha-Adrenergic Blockers
16(8)
beta-Adrenergic Blockers
24(19)
Antihypertensives
43(61)
Calcium-Channel Blockers
104(15)
Diuretics
119(22)
Ganglionic Blocking Agents
141(3)
Peripheral Vasodilators
144(14)
Antianginal, Antiarrhythmic, and Cardiotonic Agents
158(91)
beta-Adrenergic Blockers
158(1)
Antianginals
158(23)
Antiarrhythmics
181(34)
Bradycardiac Agents
215(1)
Calcium-Channel Blockers
215(1)
Cardiotonics
215(20)
Coronary Vasodilators
235(14)
Antihypercholesterolemic Agents
249(18)
Antihyperlipoproteinemics
249(16)
Cholelitholytic Agents
265(1)
Lipotropics
266(1)
Blood Formation and Coagulation Agents
267(33)
Antifibrotics
267(1)
Antineutropenics
268(1)
Antithrombocythemics
269(1)
Antithrombotics
269(12)
Fibrinogen Receptor Antagonists
281(1)
Hematinics
282(5)
Hematopoietics
287(1)
Hemolytics
288(1)
Hemostatics
288(5)
Thrombolytics
293(5)
Thromboxane Inhibitors
298
Vasoprotectants
296(4)
Water and Electrolyte Balancing Agents
300(25)
Aldosterone Antagonists
300(2)
Antidiarrheals
302(4)
Antidiuretics
306(2)
Antihyperphosphatemics
308(1)
Antihypertensives
308(1)
Antihypotensives
308(4)
Carbonic Anhydrase Inhibitors
312(2)
Diuretics
314(1)
Ion Exchangers
314(1)
Plasma Volume Expanders
314(1)
Replenishers
315(5)
Uricosurics
320(5)
PART II INDEXES 325(128)
CAS Registry Number Index
327(20)
EINECS Number Index
347(10)
Name and Synonym Index
357(96)
PART III MANUFACTURERS AND SUPPLIERS DIRECTORY 453

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