Astrocytes: Wiring the Brain

by Scemes; Eliana

• ISBN13: 9781439825846
• ISBN10: 143982584X
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-11-28
• Publisher: CRC Press

Summary

An up to date look at the role of astrocytes in CNS function and dysfunction, this volume emphasizes the unique capacity of astrocytes for diverse cellular connection and the resulting implications. Beginning with an examination of functional biomarkers at the cellular interface between astrocytes and a wide range of CNS cells, chapters cover molecular components including ion channels, transporters, and membrane receptors; astrocyte types and subtypes; and astrocyte cellular partners such as neurons, oligodendrocytes, and brain endothelial cells. The second section considers the astrocyte action in epilepsy, neuro-inflammation, and psychiatric disorders.

Table of Contents

Series Preface	p. xi
Preface: The Astrocyte: A Polarized Cell	p. xiii
Acknowledgments	p. xv
Contributors	p. xvii
Introduction to Cluster A: Functional Biomarkers at the Interface
Mature Protoplasmic Mammalian Astrocytes: Morphology, Interrelationships, and Implications for Function	p. 3
Biomarkers of Astrocyte Microdomains: Focus on Gap Junctions, Purinergic Receptors, and Aquaporins	p. 25
Adhesion Molecules and Their Function in Astrocyte Polarity	p. 63
Contribution of Astrocytes to CNS Immunity: Roles of Pattern Recognition Receptors (PRRs)	p. 107
Introduction to Cluster B: Establishment of Functional Units: Multimodality at the Tips
Neuroglial Networks: Glial Wiring Also Matters	p. 139
Astrocyte-Neuron Communication: What Goes Wrong in Pathology?	p. 157
Blood-Brain Barrier and the Neural Vascular Unit	p. 179
Oligodendrocytes: Gateway to the Panglial Syncytium	p. 205
Microglia and Non-CNS Cells in Paracrine Signaling and CNS Immunity: Effects of Pathogens, Age, and Life History	p. 237
CNS Pathology: Disruption of Astrocyte Connectivity: Introduction
Astrocytes in Epilepsy	p. 261
Astrocyte Involvement in the Acquired Demyelinating Diseases	p. 283
Neuroglia in Alzheimer's Disease	p. 311
The Role of Glial Pathology in Autism	p. 339
Astrocytes in Major Depressive Disorder and Schizophrenia: Pathophysiological and Therapeutic Aspects	p. 357
Index	p. 387
Table of Contents provided by Ingram. All Rights Reserved.