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Basic Concepts in Pharmacology,9780071458184

Basic Concepts in Pharmacology

by
Edition:
3rd
ISBN13:

9780071458184

ISBN10:
0071458182
Format:
Paperback
Pub. Date:
9/26/2005
Publisher(s):
McGraw-Hill Professional
List Price: $38.95

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This is the 3rd edition with a publication date of 9/26/2005.
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  • The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any CDs, lab manuals, study guides, etc.

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Summary

This resource offers a proven way for learning the most difficult-to-understand concepts in pharmacology and provides a study system that sets priorities, minimizes memorization, and reduces stress.Includes study techniques not found in any competing book Clearly explains each fundamental principal of drug actions Organizes and condenses must-know drug information Numerous summary boxes, illustrations, and tables Newly updated information on poisoning/toxicology and coverage of new classes of drugs such as fusion inhibitors for HIV, antibiotic and antifungal drugs, and new drugs for cancer, immune suppression, and more

Author Biography

Janet Stringer, MD - Baylor College of Medicine, Jewish Institute for Medical Research

Table of Contents

Preface xvii
CHAPTER 1 WHERE TO START 1(6)
Part I General Principles
CHAPTER 2 RECEPTOR THEORY
7(7)
Agonists
7(2)
Efficacy and Potency
9(1)
Therapeutic Index
9(1)
Antagonists
10(2)
Inverse Agonists
12(2)
CHAPTER 3 ABSORPTION, DISTRIBUTION, AND CLEARANCE
14(6)
First-Pass Effect
14(1)
How Drugs Cross Membranes
15(2)
Bioavailability
17(1)
Total Body Clearance
18(2)
CHAPTER 4 PHARMACOKINETICS
20(9)
Volume of Distribution
20(1)
First-Order Kinetics
21(3)
Zero-Order Kinetics
24(1)
Steady-State Concentration
25(2)
Time Needed to Reach Steady State
27(1)
Loading Dose
27(2)
CHAPTER 5 DRUG METABOLISM AND RENAL ELIMINATION
29(4)
Liver Metabolism
29(1)
Renal Excretion
30(3)
Part II Drugs that Affect the Autonomic Nervous System
CHAPTER 6 REVIEW OF THE AUTONOMIC NERVOUS SYTEM
33(11)
Why Include this Material?
33(1)
Relevant Anatomy
34(3)
Synthesis, Storage, Release, and Removal of Transmitters
37(2)
Receptors
39(1)
General Rules of Innervation
40(3)
Presynaptic Receptors
43(1)
CHAPTER 7 CHOLINERGIC AGONISTS
44(6)
Organization of Class
44(2)
Direct Cholinergic Agonists
46(1)
Cholinesterase Inhibitors
47(3)
CHAPTER 8 CHOLINERGIC ANTAGONISTS
50(5)
Organization of Class
50(1)
Muscarinic Antagonists
50(3)
Ganglionic Blockers
53(1)
Neuromuscular Blockers
53(2)
CHAPTER 9 ADRENERGIC AGONISTS
55(7)
Organization of Class
55(1)
Direct-Acting Agonists
56(2)
Dopamine
58(1)
Indirect-Acting Agents
58(1)
Cardiovascular Effects of Norepinephrine, Epinephrine, and Isoproterenol
59(3)
CHAPTER 10 ADRENERGIC ANTAGONISTS
62(9)
Organization of Class
62(1)
Central Blockers
63(1)
α-Blockers
63(2)
β-Blockers
65(2)
Mixed α- and β-Blockers
67(4)
Part III Drugs that Affect the Cardiovascular System
CHAPTER 11 ANTIHYPERTENSIVE DRUGS
71(12)
Organization of Class
71(2)
Diuretics
73(2)
Drugs that Interfere with the Renin-angiotensin System
75(3)
Angiotensin-Converting Enzyme (ACE) Inhibitors
75(2)
Angiotensin II Receptor Antagonists
77(1)
Selective Aldosterone Receptor Antagonists
77(1)
Calcium Channel Blockers
78(1)
Nitrates
79(1)
Other Direct Vasodilators
80(1)
α- and β-Blockers
81(1)
Clonidine
82(1)
CHAPTER 12 DRUGS USED IN ISCHEMIC HEART DISEASE AND CONGESTIVE HEART FAILURE
83(5)
Ischemic Heart Disease
83(1)
Congestive Heart Failure
84(1)
Reduction of Cardiac Workload
84(1)
Control of Excessive Fluid
85(1)
Enhancement of Contractility
85(3)
Cardiac Glycosides
85(1)
Sympathomimetics
86(1)
Phosphodiesterase Inhibitors
87(1)
CHAPTER 13 ANTIARRHYTHMIC DRUGS
88(8)
Organization of Class
88(1)
Class I Drugs (Sodium Channel Blockers)
89(2)
Class II Drugs (β-Blockers)
91(1)
Class III Drugs (Potassium Channel Blockers)
92(2)
Class IV Drugs (Calcium Channel Blockers)
94(1)
Other Antiarrhythmic Drugs
94(1)
Drugs that Increase Heart Rate
95(1)
CHAPTER 14 DRUGS THAT AFFECT BLOOD
96(9)
Organization of Class
96(1)
Antiplatelet Agents
97(1)
Anticoagulants
98(3)
Thrombolytic Drugs
101(2)
Phosphodiesterase Inhibitors
103(1)
Drugs Used in the Treament of Anemia
103(2)
CHAPTER 15 LIPID-LOWERING DRUGS
105(6)
Organization of Class
105(1)
Additional Explanation of Mechanisms
106(5)
Part IV Drugs that Act on the Central Nervous System
CHAPTER 16 DRUGS USED IN ALZHEIMER'S DISEASE
111(2)
Organization of Class
111(1)
Cholinesterase Inhibitors
112(1)
NMDA Blocker
112(1)
CHAPTER 17 ANXIOLYTIC AND HYPNOTIC DRUGS
113(8)
Tolerance and Dependence
113(1)
Organization of Class
114(1)
Barbiturates
115(2)
Benzodiazepines
117(3)
Buspirone
120(1)
CHAPTER 18 ANTIDEPRESSANTS AND LITHIUM
121(7)
Organization of Class
121(1)
Serotonin-Specific Reuptake Inhibitors (SSRIs)
122(1)
Heterocyclics
123(1)
Monoamine Oxidase (MAO) Inhibitors
124(1)
Other Antidepressants
125(2)
Drugs Used in Bipolar Disorder
127(1)
CHAPTER 19 ANTIPSYCHOTICS OR NEUROLEPTICS
128(5)
Organization of Class
128(2)
Typical Antipsychotics (First Generation)
130(1)
Serotonin-Dopamine Antagonists (Second Generation)
131(1)
Neuroleptic Malignant Syndrome
132(1)
CHAPTER 20 DRUGS USED IN PARKINSON'S DISEASE
133(4)
Organization of Class
133(1)
Dopamine Replacement Therapy
134(1)
Dopamine Agonist Therapy
135(1)
Anticholinergic Therapy
136(1)
CHAPTER 21 ANTIEPILEPTIC DRUGS
137(5)
Organization of Class
137(2)
Important Details About the Four Most Important Drugs
139(1)
Other Drugs to Consider
140(2)
CHAPTER 22 NARCOTICS (OPIATES)
142(6)
Organization of Class
142(2)
Actions of Morphine and the Other Agonists
144(1)
Distinguishing Features of Some Agonists
145(1)
Opioid Antagonists
146(1)
Opioid Agonist-Antagonists
147(1)
CHAPTER 23 GENERAL ANESTHETICS
148(5)
Organization of Class
148(1)
Uptake and Distribution of Inhalational Anesthetics
149(1)
Elimination of Inhalational Anesthetics
150(1)
Potency of General Anesthetics
151(1)
Specific Gases and Volatile Liquids
151(1)
Specific Intravenous Agents
152(1)
CHAPTER 24 LOCAL ANESTHETICS
153(6)
Organization of Class
153(1)
Mechanism of Action
154(1)
Special Features About Individual Agents
155(4)
Part V Chemotherapeutic Agents
CHAPTER 25 INTRODUCTION TO CHEMOTHERAPY
159(6)
Approach to the Antimicrobials
159(1)
General Principles of Therapy
160(1)
Definitions
161(1)
Important Concepts to Understand
161(3)
Classification of Antimicrobials
164(1)
CHAPTER 26 INHIBITORS OF CELL WALL SYNTHESIS
165(9)
General Features
165(1)
β-Lactams
166(6)
Penicillins
168(1)
Cephalosporins
169(2)
Carbapenems
171(1)
Monobactams (Aztreonam)
171(1)
Other Inhibitors of Cell Wall Synthesis
172(2)
Vancomycin
172(1)
Bacitracin
172(1)
Fosfomycin
172(1)
Daptomycin
173(1)
CHAPTER 27 PROTEIN SYNTHESIS INHIBITORS
174(7)
General Features
174(1)
Aminoglycosides
175(2)
Tetracyclines
177(1)
Macrolides
178(1)
Streptogramins and Oxazolidinones
179(1)
Chloramphenicol
179(1)
Clindamycin
180(1)
CHAPTER 28 FOLATE ANTAGONISTS
181(2)
Mechanism of Action
181(1)
Selected Features
182(1)
CHAPTER 29 QUINOLONES AND URINARY TRACT ANTISEPTICS
183(3)
Drugs in this Group
183(1)
Quinolones
184(1)
Methenamine
185(1)
CHAPTER 30 DRUGS USED IN TUBERCULOSIS AND LEPROSY
186(5)
Organization of Class
186(1)
Isoniazid
187(1)
Rifampin
188(1)
Pyrazinamide
189(1)
Ethambutol
189(1)
Dapsone
189(2)
CHAPTER 31 ANTIFUNGAL DRUGS
191(5)
Organization of Class
191(1)
Polyene Antifungals
192(2)
Azole Antifungals
194(1)
Caspofungin
195(1)
Terbinafine and Griseofulvin
195(1)
CHAPTER 32 ANTHELMINTIC DRUGS
196(3)
Organization of Class
196(1)
Drugs Used Against Cestodes and Trematodes
197(1)
Drugs Used Against Nematodes
197(1)
Drugs Used Against Filaria
198(1)
CHAPTER 33 ANTIVIRAL DRUGS
199(5)
Organization of Class
199(1)
Anti-HIV Drugs
200(1)
Drugs Used in Influenza
201(1)
Other Antivirals
202(2)
CHAPTER 34 ANTIPROTOZOAL DRUGS
204(4)
Organization of Class
204(1)
Metronidazole
205(1)
Antimalarial Agents
205(1)
Therapeutic Considerations
206(1)
Special Features
207(1)
CHAPTER 35 ANTICANCER DRUGS
208(17)
Organization of Class
208(2)
Terminology and General Principles of Therapy
210(2)
Adverse Effects
212(2)
Cytotoxic Drugs
214(5)
Alkylating Agents
214(1)
Antimetabolites
214(2)
Antibiotics and Other Natural Products
216(2)
Antibodies
218(1)
Other Cytotoxic Drugs
219(1)
Hormonal Agents
219(2)
Miscellaneous Agents
221(4)
Part VI Drugs that Affect the Endocrine System
CHAPTER 36 ADRENOCORTICAL HORMONES
225(5)
Organization of Class
225(3)
Glucocorticoids
228(1)
Mineralocorticoids
229(1)
Inhibitors of Adrenocorticoids Synthesis
229(1)
CHAPTER 37 SEX STEROIDS
230(9)
Organization of Class
230(2)
Estrogens
232(1)
Antiestrogens
233(1)
Progestins
233(1)
Antiprogestins
234(1)
Oral Contraceptives
234(1)
Androgens
235(1)
Antiandrogens
236(1)
GnRH Agonists and Antagonists
236(1)
PDE5 Inhibitors
237(2)
CHAPTER 38 THYROID AND PARATHYROID DRUGS
239(4)
Organization of Class
239(1)
Thyroid Replacement Therapy
240(1)
Drugs that are Thyroid Downers
240(1)
Parathyroid Drugs
241(2)
CHAPTER 39 INSULIN, GLUCAGON, AND ORAL HYPOGLYCEMIC DRUGS
243(8)
Organization of Class
243(1)
Insulins
244(1)
Oral Hypoglycemic Agents
245(6)
Part VII Miscellaneous Drugs
CHAPTER 40 HISTAMINE AND ANTIHISTAMINES
251(3)
Organization of Class
251(1)
H1 Receptor Antagonists
252(2)
CHAPTER 41 RESPIRATORY DRUGS
254(4)
Organization of Class
254(1)
β Agonists
255(1)
Methylxanthines
255(1)
Cholinergic Antagonists
256(1)
Leukotriene Modifiers
256(1)
Cromolyn and Omalizumab
256(1)
Pulmonary Hypertension
257(1)
CHAPTER 42 DRUGS THAT AFFECT THE GI TRACT
258(5)
Organization of Class
258(1)
Drugs that Act in the Upper GI Tract
258(2)
Drugs that Act in the Lower GI Tract
260(3)
CHAPTER 43 NONNARCOTIC ANALGESICS AND ANTI-INFLAMMATORY DRUGS
263(9)
Organization of Class
263(1)
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
264(1)
COX-2 Inhibitors
265(1)
Salicylates, Including Aspirin
266(2)
Acetaminophen
268(1)
Other Drugs for Arthritis
269(1)
Antigout Agents
270(1)
Drugs Used in the Treatment of Headaches
271(1)
CHAPTER 44 IMMUNOSUPPRESSIYES
272(2)
Organization of Class
272(1)
Calcineurin Inhibitors
273(1)
Mycophenolate Mofetil and Azathioprine
273(1)
Monoclonal Antibodies
273(1)
CHAPTER 45 DRUGS USED IN OSTEOPOROSIS
274(4)
Organization of Class
274(1)
Bisphosphonates
275(1)
Selective Estrogen Receptor Modulators (SERMs)
275(1)
Estrogens
276(1)
Calcitonin
276(1)
Other Agents
276(2)
CHAPTER 46 TOXICOLOGY AND POISONING
278(3)
Principles of Toxicology
278(1)
General Principles in the Treatment of Poisoning
279(1)
Specific Antidotes
280(1)
Index 281


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