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This book provides biomedical researchers and students with a state-of-the-art assessment of the application of bioinformatics to biomedical science and clinical applications. Contemporary biomedical and clinical researches are constantly pushed forward by the rapid advancement of various high throughput technologies on all the DNA, RNA and protein levels. These technologies include, for example, the advanced genome sequencing technology, microarray, ChIP-Chip and mass spectrometry. These technologies enable researchers to conduct investigations on human health and disease in a systematic, genome-wide scale. Technologies were developed and improved in order to have the capability of generating vast amounts of raw data. Bioinformatics methodologies have therefore been in great demand to unleash the power of these technologies for basic biomedical science and clinical applications.