Bioinformatics Principles and Applications

by Ghosh, Zhumar; Mallick, Bibekanand

• ISBN13: 9780195692303
• ISBN10: 0195692306
• Format: Paperback
• Copyright: 2015-03-01
• Publisher: Oxford University Press

Summary

Bioinformatics: Principles and Applications is a comprehensive text designed to cater to the needs of undergraduate and postgraduate students of biotechnology and bioinformatics. This book will also cater to the requirements of students pursuing short-term diploma as also DOEACC courses in bioinformatics.

Beginning with the aim and scope of bioinformatics, the book discusses in detail the essentials of the subject, such as bio-algorithms, bio-databases, molecular viewers, gene annotation methods, molecular phylogeny, and bio-molecular simulations. It further discusses the applications of bioinformatics in protein modeling and computer-aided drug design. The book also presents a discussion on molecular docking, including guidelines for using AutoDock software. The usage of select bioinformatics commercial software modules is also discussed. Written in a lucid style and user-friendly manner, the book with its wide and up to date coverage will be useful to students as well as practising professionals.

Author Biography

Zhumar Ghosh, Researcher, Stanford University School of Medicine, California,Bibekanand Mallick, Senior Researcher in Bioinformatics, Computational Biology Group, Indian Association for the Cultivation of Science, Kolkata

Dr. Zhumur Ghosh is currently a researcher at the Stanford University School of Medicine, California, USA. A PhD from Computational Biology Group of the Indian Association for the Cultivation of Science, Kolkata, she did her Masters in Physics from University of Calcutta and Advanced Diploma in Bioinformatics from the Department of Biophysics, Molecular Biology and Genetics, University of Calcutta. She has also published papers in several national and international journals of repute.

Dr. Bibekanand Mallick is a researcher in bioinformatics at Wadsworth Center, New York State Department of Health, New York, USA. He completed his Ph D from Indian Association for the Cultivation of Science (IACS), Kolkata and M. Tech in Biotechnology & Biochemical Engineering from Indian Institute of Technology (IIT) Kharagpur. He has published papers in several international journals of repute.

Table of Contents

Preface
Part I: Introduction to Bioinformatics
A Word on Bioinformatics
Part II: Biological Databases
Sequence and Molecular File Formats
Databases in Bioinformatics - An Introduction
Biological Sequence Databases
Protein 3D Structure and Classification Databases
Part III: Bio-algorithms and Tools
Sequence Alignment
Gene Prediction Methods: Principles and Challenges
Molecular Phylogeny
Molecular Viewers
Part IV: Protein Modelling and Drug Design
Protein Structure and Modelling
Bioinformatics in Computer-aided Drug Design
Part V: Modelling of Biomolecular Systems
Simulation and Statistical Protocols
Biochemical Networks
Part VI: Bioinformatics Essentials
Commercial Bio-software
Appendix I: Perspectives of Emerging Research Areas in Bioinformatics - RNAi, Epigenetics, and Stem Cells
Appendix II: Bioinformatics Database Collection with their Websites and Descriptions
Appendix IV: Bio-companies and Bioinformatics-related Courses Available in India
Test Your Understanding
Glossary
Index