Bioinformatics : Sequence and Genome Analysis

by Mount, David

• ISBN13: 9780879697129
• ISBN10: 0879697121
• Edition: 2nd
• Format: Paperback
• Copyright: 2004-08-16
• Publisher: Oxford

Summary

As more species#x19; genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.

Table of Contents

Historical introduction and overview	p. 1
Collecting and storing sequences in the laboratory	p. 29
Alignment of pairs of sequences	p. 65
Introduction to probability and statistical analysis of sequence alignments	p. 121
Multiple sequence alignment	p. 163
Sequence database searching for similar sequences	p. 227
Phylogenetic prediction	p. 281
Prediction of RNA secondary structure	p. 327
Gene prediction and regulation	p. 361
Protein classification and structure prediction	p. 409
Genome analysis	p. 495
Bioinformatics programming using Perl and Perl modules	p. 549
Analysis of microarrays	p. 611
Table of Contents provided by Blackwell. All Rights Reserved.