The Biology of Lipids: Trafficking, Regulation, and Function

by Simons, Kai

• ISBN13: 9781936113392
• ISBN10: 1936113392
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-07-13
• Publisher: Cold Spring Harbor Laboratory Press

Summary

As the major structural component of cell membranes, lipids not only serve as barriers but also play active roles in cellular function. In this volume, contributors explore the synthesis, metabolism, and distribution of lipid species in the cell; the composition of lipid rafts and their roles in protein trafficking and signaling; and the biophysical behavior of lipids and membranes.

Table of Contents

Preface	p. vii
Membrane Organization and Lipid Rafts	p. 1
Shotgun Lipidomics on High Resolution Mass Spectrometers	p. 19
Model Answers to Lipid Membrane Questions	p. 33
Phase Separation in Lipid Membranes	p. 49
Lipid Polymorphisms and Membrane Shape	p. 63
Curvature-Driven Lipid Sorting in Biomembranes	p. 77
Lipid Simulations: A Perspective on Lipids in Action	p. 91
Fluorescence Techniques to Study Lipid Dynamics	p. 105
Dynamic Transbilayer Lipid Asymmetry	p. 137
Glycosphingolipid Functions	p. 149
Regulation of Cholesterol and Fatty Acid Synthesis	p. 175
Distribution and Functions of Sterols and Sphingolipids	p. 189
Phosphoinositides in Cell Architecture	p. 203
Specificity of Intramembrane Protein-Lipid Interactions	p. 221
Synthesis and Biosynthetic Trafficking of Membrane Lipids	p. 239
Lipid-Mediated Endocytosis	p. 255
Not Just Fat: The Structure and Function of the Lipid Droplet	p. 269
Lysosomal Lipid Storage Diseases	p. 287
Role of Lipids in Virus Replication	p. 307
Index	p. 327
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