Biology of Parasitism

by Tschudi, Christian; Pearce, Edward J.

• ISBN13: 9780792378235
• ISBN10: 0792378237
• Format: Hardcover
• Copyright: 2000-05-01
• Publisher: Kluwer Academic Pub

Summary

Biology of Parasitism is based on the Biology of Parasitism Course at the Marine Biological Laboratory in Woods Hole, Massachusetts. Having just celebrated its 20th offering, this Course has distinguished itself as the premier, world-renowned training ground for future generations of parasitologists. The primary goal of the Course is to attract and introduce the very best and most promising young researchers to the many unresolved problems in parasitology and prepare them for their future as independent investigators in the field. The rigorous program combines state-of-the-art laboratory research with a program of visiting lecturers who bring together the most current research in the field. Since at this time there are no academic institutions that have enough depth in parasitology research or teaching faculty to provide up-to-date and state-of-the-art training, the Course has become, and will remain, a global resource for providing intensive education in modern parasitology. Biology of Parasitism is intended to present a snapshot of the content and spirit of the Biology of Parasitism Course. By presenting a series of chapters that reflect the formal lectures that students receive on a daily basis, as well as the approaches used during the laboratory section of the Course, the editors hope to share some of the science that occurs there. One part of the book presents the experimental component of the Course, in particular the subject matter of the four two-week sessions covering Immunology, Biochemistry, Cell Biology and Molecular Biology of protozoan and helminth parasites. As in the Course, the experimental part is complemented by a number of review-like chapters solicited from the large number of speakers who lecture during the Course.

Table of Contents

Contributors	ix
Preface	xv
Christian Tschudi
Edward J. Pearce
Foreword	xvii
John R. David
MOLECULAR BIOLOGY
Import of Nuclear Encoded tRNA into Mitochondria	1	(18)
Audra E. Yermovsky-Kammerer
Stephen L. Hajduk
RNA Metabolism in Trypanosomes: Approaches to Unravel pre-mRNA Signals Required for Intron Removal	19	(24)
Christian Tschudi
Elisabetta Ullu
Stable Transfection of Plasmodium berghei: A Crash Course	43	(30)
Andrew P. Waters
BIOCHEMISTRY
Malaria Chemotherapy: Paradigms from Pyrimidine Metabolism	73	(22)
Pradipsinh K. Rathod
Polyamine and Glutathione Biosynthetic Enzymes from Trypanosoma brucei and Trypanosoma cruzi	95	(26)
Lisa N. Kinch
Deirdre L. Brekken
Margaret A. Phillips
Acetylcholinesterases of Gastrointestinal Nematodes	121	(22)
Murray E. Selkirk
Ayman S. Hussein
CELL BIOLOGY
Toxoplasma as a Model Apicomplexan Parasite: Biochemistry, Cell Biology, Molecular Genetics, Genomics and Beyond	143	(26)
David S. Roos
John A. Darling
Mary G. Reynolds
Kristin M. Hager
Boris Striepen
Jessica C. Kissinger
The Trichomonad Hydrogenosome	169	(26)
Sabrina D. Dyall
Patricia J. Johnson
Lysosome Exocytosis and Invasion of Non-Phagocytic Host Cells by Trypanosoma cruzi	195	(18)
Barbara A. Burleigh
Cell Biological Approaches to the Study of Intracellular Pathogens: Motility, Invasion, Secretion and Vesicular Trafficking	213	(42)
David G. Russell
Dana G. Mordue
Wandy Beatty
Olivia K. Giddings
Jennie L. Lovett
Andreas Lingnau
Maren Lingnau
Jaime Dant
L. David Sibley
IMMUNOLOGY
Cytokine Regulation of Filaria: Induced Airway and Corneal Disease	255	(18)
Eric Pearlman
Rajeev K. Mehlotra
Musa A. Haxhiu
Laurie R. Hall
Molecular Mechanisms of Granuloma Formation in Schistosomiasis	273	(18)
Stephen J. Davies
James H. McKerrow
Experimental Approaches to Studying the Immunology of Parasitic Diseases	291	(32)
Edward J. Pearce
Phillip Scott
Appendix
Participants in the Biology of Parasitism Course 1998	320	(1)
Participants in the Biology of Parasitism Course 1999	321	(2)
Index	323