Biomedical Sciences Essential Laboratory Medicine

by Iles, Raymond; Docherty, Suzanne

• ISBN13: 9780470997758
• ISBN10: 0470997753
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-01-30
• Publisher: Wiley

Summary

Biomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. The book includes the key components of the IBMS accredited degree programmes, plus sections on actual practice in UK hospital laboratories (including the compilation of a reflective portfolio). The book is visually exciting, and written in an interesting and accessible manner while maintaining scientific rigour. Highlighted boxes within the text link the theory to actual clinical laboratory practice for example, the histopathology chapter includes a photographically illustrated flow chart of the progress of a specimen through the histopathology lab, so that students can actually see how the specimen reception/inking/cut-up/cassette/block/section/stain system works, with an emphasis on the safety procedures that ensure specimens are not confused).

Author Biography

Professor Ray Iles and Dr Suzanne Docherty, School of Health & Social Sciences, Middlesex University, Hendon Campus, London, UK.
Ray Iles has experience of writing a chapter of Kumar & Clark's Clinical Medicine (one of the market leading textbooks for medical students) and would like to provide the same kind of core textbook for biomedical science students.

Table of Contents

List of Contributors	p. xi
Preface	p. xiii
Anatomy and physiology of major organ systems	p. 1
The skeletal system	p. 1
The digestive system	p. 6
The cardiovascular system	p. 11
The urinary system	p. 17
Respiratory system	p. 21
The nervous system	p. 23
The endocrine system	p. 31
Bibliography	p. 33
Pathophysiology	p. 35
Pathophysiology: a definition	p. 35
Introduction to epidemiology	p. 35
Introduction to pharmacology	p. 38
Gastroenterology	p. 44
Liver, biliary tract and pancreatic disease	p. 50
Rheumatology	p. 56
Urinary tract disease	p. 59
Cardiovascular disease	p. 65
Respiratory disease	p. 76
Endocrine disease	p. 80
Bibliography	p. 88
Clinical cell biology and genetics	p. 89
The cell	p. 89
Genetics	p. 103
Human genetic disorders	p. 116
Important techniques in molecular cell biology	p. 136
Bibliography	p. 138
Cellular pathology	p. 139
Principles of cellular pathology	p. 139
Structure and function of normal cells, tissues and organs	p. 139
Tissues and organs	p. 140
Cellular responses to injury	p. 141
Tissue responses to injury: acute inflammation	p. 143
Tissue responses to injury: chronic inflammation	p. 149
Healing and repair	p. 151
Hyperplasia and hypertrophy	p. 154
Atherosclerosis	p. 155
Thrombosis and embolism	p. 157
Ischaemia and infarction	p. 159
Amyloid and amyloidosis	p. 160
Infections of histological importance	p. 162
Metaplasia, dysplasia and carcinoma in situ	p. 165
Neoplasia	p. 168
Clinical application and laboratory techniques	p. 175
Sampling modalities	p. 175
Fixation	p. 178
Specimen dissection	p. 180
Processing and embedding	p. 182
Microtomy	p. 184
Standard staining methods and procedures	p. 186
Frozen section	p. 190
Immunohistochemistry	p. 191
Cytopathology	p. 196
Electron microscopy	p. 197
In situ hybridization	p. 201
Bibliography	p. 203
Clinical chemistry	p. 205
Introduction	p. 205
Analytical methods	p. 205
Sample collection	p. 205
Analytical methods in clinical chemistry laboratories	p. 210
Summary: common clinical tests for sample analytes	p. 231
Clinical assessments	p. 232
Urea and electrolytes (U and Es)	p. 232
Metabolism and gastrointestinal markers	p. 234
Renal function tests	p. 236
Liver function tests	p. 237
Heart disease and lipid disorder tests	p. 238
Pancreatic function tests	p. 240
Bone disease assessment	p. 241
Endocrinological assessments	p. 241
Pregnancy tests and pregnancy clinical chemistry	p. 249
Therapeutic drug monitoring and toxicology	p. 251
Clinical chemistry at the extremes of age	p. 253
Cancer biomarkers	p. 254
Bibliography	p. 259
Medical microbiology	p. 261
Introduction	p. 261
Overview of microorganisms	p. 261
Laboratory investigation of infection	p. 265
Bacteria	p. 277
Fungi	p. 284
Parasitology ù protozoa and helminths	p. 288
Viruses	p. 290
Prions	p. 297
Infections in the immunocompromised patient	p. 298
Healthcare associated infections	p. 299
Antimicrobial agents	p. 302
Vaccines	p. 307
Conclusion	p. 309
Bibliography	p. 309
Clinical immunology	p. 311
The fundamentals of immunology	p. 311
Overview of the immune system	p. 311
Overview of the immune response	p. 316
MHC genotyping, autoimmunity and susceptibility to disease	p. 321
Physical age and immunocompetency	p. 322
Laboratory investigations and immune assessments	p. 323
Inflammation and chronic infection	p. 323
Autoimmune diseases	p. 324
Transplant rejection	p. 325
Hypersensitivities	p. 326
Immune deficiency	p. 326
Bibliography	p. 328
Haematology and transfusion science	p. 329
Introduction and components of blood	p. 329
Routine laboratory blood tests	p. 332
Haemopoiesis	p. 336
Red blood cell structure, disorders and metabolism	p. 337
Haemoglobin	p. 342
Anaemia	p. 353
Benign white blood cell disorders	p. 359
Haemostasis	p. 361
Coagulation disorders	p. 366
Myeloproliferative disorders	p. 371
Haematological malignancies	p. 373
Complement	p. 378
Blood transfusion	p. 380
Blood products	p. 390
Haemopoetic stem cell transplantation	p. 393
Bibliography	p. 395
Professional practice and biomedical science	p. 397
What is a biomedical scientist?	p. 397
The IBMS	p. 397
Professional practice and the role of the HPC	p. 398
Standards of proficiency ù biomedical scientists	p. 399
Expectations of a health professional	p. 400
Professional relationships	p. 401
The skills required for the application of practice	p. 401
Knowledge, understanding and skills	p. 402
Standards of conduct, performance and ethics l03
CPD	p. 403
Critical reflection	p. 404
IBMS CPD scheme	p. 404
The professional biomedical scientist as an agent for change in the wider healthcare setting	p. 405
Appendix	p. 407
Index	p. 413
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