9780137062706

Bioprocess Engineering Basic Concepts

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  • ISBN13:

    9780137062706

  • ISBN10:

    0137062702

  • Edition: 3rd
  • Format: Hardcover
  • Copyright: 3/24/2017
  • Publisher: Prentice Hall
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Summary

Bioprocess Engineering, Third Edition is a comprehensive update of the world's leading introductory textbook on biochemical and bioprocess engineering. Drs. Michael L. Shuler, Fikret Kargi, and Matthew DeLisa review the relevant fundamentals of biochemistry, microbiology, and molecular biology, introducing key principles that enable bioprocess engineers to achieve consistent control over biological activity. The authors introduce techniques with broad application to the production of pharmaceuticals, biologics, and commodities; to medical applications such as tissue engineering and gene therapy; and for solving critical environmental problems. Through up-to-date examples and homework problems, they introduce powerful advances that are transforming the field, ranging from genetic sequencing to new techniques for producing proteins from recombinant DNA.

Author Biography

Dr. Michael L. Shuler is Samuel B. Eckert Professor of Engineering at Cornell University. He directed the School of Chemical Engineering (1998-2002) and was founding James and Marsha McCormick Chair for Biomedical Engineering (2004-2014). He also directs the Center on the Microenvironment and Metastasis (CMM), funded by the National Cancer Institute as a Physical Sciences - Oncology Center. He has received numerous teaching, advising, and research related awards, and has been elected to the National Academy of Engineering and the American Academy of Arts and Sciences.

 

Fikret Kargi is Professor in the Department of Environmental Engineering at Dokuz Eylul University. His interests include bioprocess engineering, environmental biotechnology, wastewater treatment, biotechnology-bioengineering, and waste bioprocessing. He holds a Ph.D. in Chemical/Biochemical Engineering from Cornell.

 

Matthew DeLisa is William L. Lewis Professor of Engineering in Cornell's Department of Chemical and Biomolecular Engineering. His research focuses on understanding and controlling the molecular mechanisms underlying protein biogenesis in the complex environment of a living cell. He has invented numerous commercially important technologies for facilitating the discovery, design and manufacturing of human drugs, and has made seminal discoveries about cellular protein folding and protein translocation. DeLisa has received several awards including an NSF CAREER award, and was named one of the top 35 young innovators by MIT's Technology Review. He was elected as a fellow of the American Institute for Medical and Biological Engineering in 2014.

Table of Contents

I. INTRODUCTION
1. What is a Bioprocess Engineer?

 

II. THE BASICS OF BIOLOGY: AN ENGINEER'S PERSPECTIVE
2. An Overview of Biological Basics
3. Enzymes
4. How Cells Work
5. Major Metabolic Pathways
6. How Cells Grow and Product Formation
7. How Cellular Information is Altered

 

III. ENGINEERING PRINCIPLES FOR BIOPROCESSES
8. Operating Considerations for Bioreactors for Suspension and Immobilized Cultures
9. Selection, Scale-Up, Operation, and Control of Bioreactors
10. Recovery and Purification of Products

 

IV. APPLICATIONS TO NONCONVENTIONAL BIOLOGICAL SYSTEMS
11. Bioprocess Considerations in Using Animal Cell Cultures
12. Bioprocess Considerations in Using Plant Cell Cultures
13. Utilizing Genetically Engineered Organisms
14. Medical Applications of Bioprocess Engineering
15. Mixed Cultures
16. Epilogue
Appendix: Traditional Industrial Bioprocesses

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