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Animal Models Of Movement Disorders,9780120883820
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Animal Models Of Movement Disorders


Author(s): LeDoux
ISBN10:  0120883821
ISBN13:  9780120883820
Format:  Hardcover
Pub. Date:  12/28/2004
Publisher(s): Elsevier Science & Technology

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SummaryTable of Contents
The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to
* Includes contributions by expert movement disorder clinicians and top-level researchers in the field
* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models
Preface ix
List of Contributors
xi
SECTION A: SCIENTIFIC FOUNDATIONS
Classification and Clinical Features of Movement Disorders
1(12)
Anita J. Jurkowski
Mark Stacy
Animal Models and the Science of Movement Disorders
13(20)
Mark LeDoux
Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders
33(12)
Mai Dang
Yuqing Li
Genetics of Spontaneous Mutations in Mice
45(10)
Haixiang Peng
Colin F. Fletcher
Assessment of Movement Disorders in Rodents
55(18)
H.A. Jinnah
Ellen J. Hess
Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals
73(28)
Stephen C. Fowler
T.L. McKerchar
T.J. Zarcone
Behavior in Drosophila: Analysis and Control
101(10)
Ralph Hillman
Robert G. Pendleton
Use of C. elegans to Model Human Movement Disorders
111(16)
Guy A. Caldwell
Songsong Cao
Iyare Izevbaye
Kim A. Caldwell
SECTION B: PARKINSON DISEASE
The Phenotypic Spectrum of Parkinson Disease
127(12)
Ronald F. Pfeiffer
MPTP-Induced Nigrostriatal Injury in Nonhuman Primates
139(10)
Joel S. Perlmutter
Samer D. Tabbal
From Man to Mouse: The MPTP Model of Parkinson Disease
149(12)
Vernice Jackson-Lewis
Richard Jay Smeyne
Rotenone Rat and Other Neurotoxin Models of Parkinson Disease
161(12)
Todd B. Sherer
Ranjita Betarbet
J. Timothy Greenamyre
Drosophila Models of Parkinson Disease
173(10)
Leo J. Pallanck
Alexander J. Whitworth
Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease
183(10)
Sheila M. Fleming
Marie-Francoise Chesselet
Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease
193(16)
M. Angela Cenci
Martin Lundblad
Motor Complications in Primate Models of Parkinson Disease
209(10)
Francesco Bibbiani
Justin D. Oh
C. elegans Models of Parkinson Disease
219(8)
Suvi Vartiainen
Garry Wong
SECTION C: DYSTONIA
Clinical Features and Classification of the Human Dystonias
227(14)
Rachel Saunders-Pullman
Susan Bressman
The Genetically Dystonic Rat
241(12)
Mark LeDoux
Animal Models of Benign Essential Blepharospasm and Hemifacial Spasm
253(12)
Craig Evinger
Iris S. Kassem
Mouse Models of Dystonia
265(14)
Ellen J. Hess
H.A. Jinnah
The Owl Monkey Model of Focal Dystonia
279(8)
David T. Blake
Nancy N. Byl
Michael Merzenich
DYT1 Transgenic Mouse
287(6)
Nutan Sharma
D. Cristopher Bragg
Jeremy Petravicz
David G. Standaert
Xandra O. Breakefield
The hph-1 Mouse
293(6)
Keith Hyland
Simon J.R. Heales
SECTION D: HUNTINGTON DISEASE
Clinical and Pathological Characteristics of Huntington Disease
299(10)
Jayaraman Rao
Transgenic Rodent Models of Huntington Disease
309(8)
Gabriele Schilling
Christopher A. Ross
David R. Borchelt
Knock-in and Knock-out Models of Huntington Disease
317(12)
Paula Dietrich
Ioannis Dragatsis
Drosophila Models of Huntington Disease
329(6)
Leslie M. Thompson
J. Lawrence Marsh
SECTION E: TREMOR DISORDERS
Neurophysiologic Characterization of Tremor
335(12)
Rodger J. Elble
Essential Tremor
347(14)
Elan D. Louis
Harmaline Tremor
361(8)
Mark LeDoux
GABAA Receptor α1 Subunit Knockout Mice: A Novel Model of Essential Tremor
369(8)
Jessica L. Osterman
Jason E. Kralic
Todd K. O' Buckley
Gregg E. Homanics
A. Leslie Morrow
Production and Physiological Study of Holmes Tremor in Monkeys
377(16)
Chihiro Ohye
The Campus Syndrome in Pietrain Pigs
393(4)
Angelika Richter
SECTION F: MYOCLONUS
Pathophysiology, Neurophysiology, and Pharmacology of Human Myoclonus
397(18)
Michael R. Pranzatelli
Post-Hypoxic Myoclonus in Rodents
415(8)
Kwok-Keung Tai
Daniel D. Truong
Baboon Model of Myoclonus
423(8)
Carmen Silva-Barrat
Robert Naquet
SECTION G: TIC DISORDERS
Tourette Syndrome
431(10)
Harvey S. Singer
Constance Smith-Hicks
David Lieberman
Animal Models of Tourette Syndrome
441(8)
Kathleen Burke
Paul J. Lombroso
SECTION H: PAROXYSMAL MOVEMENT DISORDERS
Paroxysmal Dyskinesias in Humans
449(10)
Kailash P. Bhatia
The Genetically Dystonic Hamster: An Animal Model of Paroxysmal Dystonia
459(8)
Angelika Richter
Mouse Models of Hyperekplexia
467(12)
Lore Becker
Hans Weiher
Bovine Hyperekplexia
479(8)
Julie A. Dennis
Peter A. Windsor
Peter R. Schofield
Peter J. Healy
Movement Disorders in Drosophila Mutants of Potassium Channels and Biogenic Amine Pathways
487(18)
Lyle Fox
Atsushi Ueda
Brett Berke
I-Feng Peng
Chun-Fang Wu
SECTION I: PROGRESSIVE SUPRANUCLEAR PALSY AND CORTICOBASAL GANGLIONIC DEGENERATION
Progressive Supranuclear Palsy and Corticobasal Degeneration
505(10)
Irene Litvan
Genetic Susceptibility and Animal Modeling of PSP
515(14)
Parvoneh Poorkaj Navas
Ian D'Souza
Gerard D. Schellenberg
Rodent Models of Tauopathies
529(12)
Jada Lewis
Eileen McGowan
SECTION J: MULTIPLE SYSTEM ATROPHY
Clinical Spectrum and Pathological Features of Multiple System Atrophy
541(30)
Carlo Colosimo
Felix Geser
Gregor K. Wenning
Double-Lesion Animal Models of Multiple System Atrophy
571(14)
Imad Ghorayeb
Nadia Stefanova
Pierre-Olivier Fernagut
Gregor Karl Wenning
Francois Tison
A Mouse Model for Multiple System Atrophy
585(10)
Dianne M. Perez
SECTION K: ATAXIAS
Clinical and Pathological Features of Hereditary Ataxias
595(18)
Tetsuo Ashizawa
S.H. Subramony
Acquired Ataxias
613(10)
Susan L. Perlman
Animal Models of Spinocerebellar Ataxia Type 1 (SCA1)
623(8)
Michael D. Kaytor
Harry T. Orr
Spinocerebellar Ataxia Type 2 (SCA2)
631(6)
Stefan-M. Pulst
SCA7 Mouse Models
637(12)
Dominique Helmlinger
Didier Devys
Animal Models of Friedreich Ataxia
649(8)
Massimo Pandolfo
Animal Oculomotor Data Illuminate Cerebellum-Related Eye Movement Disorders
657(22)
Farrel R. Robinson
James O. Phillips
Avery H. Weiss
SECTION L: SPASTICITY
Spasticity
679(8)
Allison Brashear
Hereditary Spastic Paraplegia: Clinical Features and Animal Models
687(4)
Shirley Rainier
John K. Fink
The Spastic Rat with Sacral Spinal Cord Injury
691(8)
Philip J. Harvey
Monica Gorassini
David J. Bennett
Rat Spinal Cord Contusion Model of Spasticity
699(14)
Floyd J. Thompson
Prodip Bose
SECTION M: DRUG-INDUCED MOVEMENT DISORDERS
Drug-Induced Movement Disorders
713(12)
Joseph H. Friedman
Hubert H. Fernandez
Neuroleptic-Induced Acute Dystonia and Tardive Dyskinesia in Primates
725(10)
Gary S. Linn
Motor Effects of Typical and Atypical Antipsychotic Drugs in Rodents
735(10)
Stephen C. Fowler
T.L. McKerchar
T.J. Zarcone
Animal Models of Drug-Induced Akathisia
745(10)
Perminder S. Sachdev
SECTION N: RESTLESS LEGS SYNDROME
Clinical Features and Animal Models of Restless Legs Syndrome and Periodic Limb Movement
755(4)
P.C. Baier
Claudia Trenkwalder
Index 759

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