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9780444515001

Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

by ; ;
  • ISBN13:

    9780444515001

  • ISBN10:

    0444515003

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2005-07-06
  • Publisher: Elsevier Science

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Summary

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Table of Contents

Contributors ix
Preface xi
Section I. Caveolae Organization and Role in Lipid Cholesterol Metabolism
Lipid Rafts and Caveolae Organization
Friedhelm Schroeder
Barbara P. Atshaves
Adalberto M. Gallegos
Avery L. McIntosh
J. C. Steve Liu
Ann B. Kier
Huan Huang
Judith M. Ball
Introduction
3(3)
A Non-detergent Method of Simultaneously Isolating Caveolae/Lipid Rafts and Non-raft Domains
6(3)
Lipid Composition of Lipid Rafts/Caveolae and Non-raft Domains
9(2)
Fluidity and Structure of Lipid Rafts/Caveolae and Non-rafts
11(2)
Cholesterol Organization in Lipid Rafts/Caveolae and Non-rafts
13(3)
Sterol Carrier Protein-2 Selectively Modulates Cholesterol Dynamics in Lipid Rafts/Caveolae
16(2)
Multiphoton Imaging of Sterol Structure and Distribution in Lipid Rafts/Caveolae of Living Cells
18(4)
Caveolin Interacts with Select Lipids in Caveolae
22(1)
Peptide-Protein Interactions with Model Membrane Lipid Rafts: SCP-2
23(2)
Peptide-Protein Interactions with Model Membrane Lipid Rafts: Cholera Toxin and Rotavirus NSP4, an Enterotoxin
25(2)
Prospectus
27(11)
References
28(10)
Caveolae and the Regulation of Cellular Cholesterol Homeostasis
William V. Everson
Eric J. Smart
Introduction
38(1)
Organization
38(1)
Endothelial Transcytosis
38(1)
Proteins Associated with Caveolae and Lipid Rafts Confer Stability
39(1)
Annexin II Is a Prominent Protein in Caveolae/Lipid Rafts and Lipid Raft Vesicles
40(2)
Focal Adhesions Are Specialized Caveolae
42(1)
Cholesterol and Caveolin Internalization
42(1)
Caveolin Chaperone Complexes, Cholesterol Trafficking, and Caveolae Organization
43(2)
Caveolin Acylation and Chaperone Complex-Mediated Cholesterol Trafficking
45(1)
Cholesterol Transport in Specialized Cells
45(1)
Caveolin Vesicles Connect the Surface to a Network of Intracellular Tubules and Vesicles
46(1)
Annexin II and Lipid Raft Endocytosis and Exocytosis
46(2)
PM Cholesterol Content Alters Caveola Vesicle Internalization
48(1)
Microfilaments and Microtubules Regulate Distinct Steps in the Caveolae Trafficking
48(1)
Uptake of SV40 and Trafficking to the Caveosome and Smooth ER
49(1)
Autocrine Motility Factor Trafficks via Caveola Vesicles to Two Regions of the ER
49(1)
Orientation of Cholesterol and Proteins in the Lipid Raft Bilayer
50(1)
Cholesterol Trafficking and Caveolae Physiology: eNOS Signaling in Vasodilation
51(1)
``Liquid Ordered Domain'' Fluidity and eNOS Signaling
51(1)
Conclusion
52(7)
References
53(6)
Section II. Caveolae Organization and the Regulation of Endocytosis
The Caveolae Internalization Machinery
L. S. Orlichenko
M. A. McNiven
Introduction: Caveolae as Endocytic Organelles
59(1)
Caveolin Recruitment to the Plasma Membrane
60(1)
Caveolar Scission
61(11)
Perspectives
72(7)
References
72(7)
Lipid Raft-Mediated Entry of Bacteria into Host Cells
Matthew J. Duncan
Soman N. Abraham
Introduction
79(1)
Lipid Raft-Mediated Entry of Bacteria into Host Cells
80(5)
Conclusion
85(6)
References
85(6)
Section III. Examples of the Role of Caveolins in Cell Signalling
The Caveolin Interaction with Endothelial Nitric Oxide Synthase (eNOS)
Olivier Feron
Introduction
91(1)
The Caveolin-eNOS Interactions
92(2)
Caveolin, eNOS, and Cholesterol
94(3)
Caveolin, eNOS, and Angiogenesis
97(3)
Caveolin, eNOS, and Endothelial Permeability
100(3)
Caveolin, eNOS, and Vasodilation
103(1)
Conclusion
104(5)
References
104(5)
Caveolae and Estrogen Receptor Signaling
Philip W. Shaul
Ken L. Chambliss
Introduction
109(1)
Estrogen and eNOS Activation
110(1)
Localization of eNOS Activation by E2 to Plasma Membrane
110(2)
Characterization of Plasma Membrane ER in Endothelial Cells
112(2)
Localization of ERα-eNOS Coupling to Caveolae
114(1)
Comparable Role of ERβ in Endothelial Caveolae
114(3)
G-proteins and ER Coupling to eNOS
117(3)
Additional Intricacies about ER in Caveolae
120(1)
Summary and Future Directions
121(4)
References
122(3)
eNOS Regulation by Sphingosine 1-Phosphate and Caveolin
Junsuke Igarashi
eNOS as a Key Vascular Enzyme
125(1)
eNOS Acylation, Targeting to Caveolae, and Regulation by Caveolin
126(1)
Sphingosine 1-Phosphate and Regulation of Vascular Endothelial Cells
127(1)
eNOS Activation by SIP and Endothelial Signaling
128(1)
Roles of Caveolae for eNOS Regulation by SIP
129(2)
eNOS Regulation and Receptor Cross-talk of SIP Signaling
131(1)
Implications for Vascular Physiology
132(1)
Possibilities in Nonendothelial Cells
133(2)
Concluding Remarks
135(7)
References
135(7)
Insulin Signaling and Caveolae
Peter Stralfors
Insulin Action
142(2)
Caveolae and the Adipocyte
144(3)
Insulin Signaling in Caveolae
147(5)
Mechanisms for Targeting the Insulin Receptor to Caveolae
152(3)
Adipose Tissue and Insulin Signaling in Caveolin-1-Deficient Animals
155(2)
Insulin-Stimulated Glucose Uptake in Caveolae
157(4)
Insulin Signaling and Caveolae in Other Tissues
161(1)
Conclusion
162(12)
References
162(12)
Section IV. Caveolae and Pathologies
Caveolin-3, Caveolae, and Hereditary Muscle Diseases
Matthias Vorgerd
Caveolin-3 in Muscular Dystrophies
174(2)
Rippling Muscle Disease (RMD)
176(3)
Distal Myopathy
179(1)
HyperCKemia
179(1)
Cardiomyopathy
179(1)
Intrafamilial Clinical Heterogeneity in CAV3 Families
180(1)
Pathogenesis of CAV3 Deficiency
180(3)
Summary
183(5)
References
184(4)
Caveolae and Caveolins in the Vascular System: Functional Roles in Endothelia, Macrophages, and Smooth Muscle Cells
Ghada S. Hassan
Michael P. Lisanti
Philippe G. Frank
Caveolae and Caveolins in Endothelial Celis
188(10)
Caveolin-1 in Macrophages
198(1)
Caveolae and Caveolins in Vascular Smooth Muscle Cells
199(3)
Conclusions
202(9)
References
204(7)
Caveolin Proteins in Cardiopulmonary Disease and Lung Cancers
Jean-Francois Jasmin
Philippe G. Frank
Michael P. Lisanti
Caveolin Proteins and the Cardiopulmonary System
211(16)
Conclusions
227(8)
References
228(7)
Abbreviations and Acronyms 235(2)
Index 237

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