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Essential Developmental Biology,9780632052332
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Essential Developmental Biology


Edition: 1st
Author(s): Slack, J. M. W.
ISBN10:  0632052333
ISBN13:  9780632052332
Format:  Paperback
Pub. Date:  2/1/2001
Publisher(s): Blackwell Pub

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SummaryTable of Contents
The past 15 years has seen revolutionary advances not only in our understanding of the processes by which an egg develops into an adult, but also in the application of this knowledge to the areas of reproductive technology, drug development and organ replacement. Essential Developmental Biology is a concise and well-illustrated treatment of this subject for undergraduates. Assuming only the basics of cell biology and genetics, the book starts off by introducing the principles and approaches of developmental biology. The second section covers the characteristic development of each of the principal model species used for research and final chapters are devoted to organ development. With an emphasis throughout on the evidence underpinning the main conclusions, this book is suitable as the key text for both introductory and more advanced courses in developmental biology. Professor Jonathan Slack is a leading authority in developmental biology and author of the well-received book From Egg to Embryo.
Preface v
Section 1: Groundwork 1(86)
The Excitement of Developmental Biology
3(3)
Where the subject came from
3(1)
Central position in biology
3(1)
Impact on society
4(1)
Future impact
4(2)
General Problems of Development
6(4)
Nuclear totipotency, cloning of animals
7(3)
Key Molecular Components
10(17)
Genes
10(3)
Signalling systems
13(3)
Cytoskeleton
16(2)
Cell adhesion molecules
18(1)
Appendix
19(1)
Transcription factor families
19(1)
Inducing factor families
20(4)
Cell adhesion molecules
24(1)
Extracellular matrix components
25(2)
Common Features of Development
27(21)
Gametogenesis
27(3)
Fertilization
30(1)
Early development
30(5)
Morphogenetic processes
35(6)
Evolution of developmental mechanisms
41(7)
Developmental Genetics
48(12)
Developmental mutants
48(5)
Screening for mutants
53(2)
Cloning of genes
55(1)
Transgenesis
55(2)
Limitations of developmental genetics
57(3)
Experimental Embryology
60(13)
Normal development
60(3)
Developmental commitment
63(3)
Acquisition of commitment
66(2)
Homeotic genes
68(5)
Techniques for the Study of Development
73(14)
Microscopy
73(3)
Study of gene expression by biochemical methods
76(3)
In situ methods
79(2)
Microinjection
81(2)
Cell-labelling methods
83(1)
Reporter genes
84(3)
Section 2: Major Model Organisms 87(118)
Model Organisms
89(4)
Availability and cost
89(1)
Access and micromanipulation
90(1)
Genetics and genome maps
90(1)
Relevance
91(2)
Xenopus
93(23)
Oogenesis, maturation, fertilization
93(1)
Embryonic development
94(6)
Experimental methods
100(3)
Regional specification
103(5)
Inductive interactions
108(8)
The Zebrafish
116(6)
Normal development
116(1)
Mutagenesis
117(3)
Regional specification
120(2)
The Chick
122(18)
Normal development
123(6)
Regional specification of the early embryo
129(2)
Description of organogenesis in the chick
131(9)
The Mouse
140(25)
Normal development
140(9)
Technology of mouse development
149(9)
Regional specification in development
158(4)
Other topics in mouse development
162(3)
Drosophila
165(26)
Insects
165(1)
Normal development
166(3)
Drosophila developmental genetics
169(4)
Overview of the developmental program
173(1)
The dorsoventral pattern
174(4)
The anteroposterior system
178(13)
Caenorhabditis elegans
191(14)
Normal development
191(2)
Regional specification in the embryo
193(5)
Analysis of postembryonic development
198(2)
Programmed cell death
200(5)
Section 3: Organogenesis and Regeneration 205(108)
Tissues
207(5)
Epithelial tissues
207(1)
Connective tissues
207(2)
Muscle
209(1)
Neural tissues
209(1)
Blood and blood vessels
209(3)
Development of the Nervous System
212(24)
Overall structure and cell types
212(4)
Anteroposterior patterning of the neural plate
216(3)
Dorsoventral patterning of the neural tube
219(1)
Neurogenesis and gliogenesis
220(4)
The neural crest
224(3)
Development of neuronal connectivity
227(9)
Development of Mesodermal Organs
236(26)
Somitogenesis
236(6)
The kidney
242(3)
Gonadal development
245(5)
Limb development
250(12)
Drosophila Imaginal Discs
262(16)
Metamorphosis
262(1)
Genetic study of larval development
262(2)
Mitotic recombination
264(4)
Disc development
268(4)
Regional patterning of the wing disc
272(3)
Regional patterning of the leg disc
275(3)
Stem Cells and Tissue Growth
278(18)
Size and proportion
278(1)
Renewal tissues
279(9)
Growth in stature
288(3)
Postnatal disorders of growth and differentiation
291(1)
Cancer
291(5)
Regeneration of Missing Parts
296(17)
Distribution of regenerative capacity
296(1)
Planarian regeneration
297(3)
Vertebrate limb regeneration
300(13)
Index 313

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