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A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

The book is specifically designed to provide quick access to the latest advances in the growing field of G protein coupled receptors. In addition to providing background information regarding the functions and nature of the receptor it also covers the current research in the field. A review of the structure and function of the receptor, receptor regulation, the role of dimerization and regulation to receptor function, and the receptors application in pharmacological applications, are presented in clear and amply illustrated format. In addition, the text provides a review of both the traditional and current methodology for studying receptor structure, interactions and regulation. Pharmacological, biochemical and biophysical methods are presented including; traditional immunoprecipitation, Fluorescence Resonance Energy Transfer, and Bioluminescence Resonance Energy Transfer. It is written for any biologist, researcher, or graduate student who is looking to expand their knowledge of the G protein coupled receptor and its molecular interactions. It provides an excellent concise reference for the scholar and an ideal laboratory reference for investigators. Each topic or technique includes an extensive bibliography for further reference. This book will make an excellent concise and informative addition to the biochemists, and pharmacologist's reference library.Reviewer: Christine Bezotte, Associate Professor of Biology, Elmira College, cbezotte@elmira.edu Copyright 2006 E-Streams Reviews.