| Preface |
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ix | |
| Acknowledgments |
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xi | |
| About the Authors |
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xv | |
| Introduction |
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xvii | |
| Chapter 1 The History and Scope of History |
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1 | (44) |
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2 | (3) |
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5 | (9) |
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Foundations of Epidemiology |
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14 | (8) |
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Historical Antecedents of Epidemiology |
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22 | (12) |
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Recent Applications of Epidemiology |
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34 | (6) |
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40 | (1) |
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Study Questions and Exercises |
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40 | (5) |
| Chapter 2 Practical Applications of Epidemiology |
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45 | (42) |
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46 | (2) |
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Applications for the Assessment of the Health Status of Populations and Delivery of Health Services |
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48 | (18) |
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Applications Relevant to Disease Etiology |
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66 | (15) |
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81 | (1) |
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Study Questions and Exercises |
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81 | (4) |
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Appendix 2: Data for Study Question 9 |
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85 | (2) |
| Chapter 3 Measures of Morbidity and Mortality Used in Epidemiology |
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87 | (40) |
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88 | (1) |
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Definitions of Count, Proportion, Ratio, and Rate |
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88 | (9) |
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97 | (2) |
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Interrelationship Between Prevalence and Incidence |
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99 | (1) |
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Applications of Incidence Data |
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100 | (1) |
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100 | (9) |
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109 | (3) |
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112 | (9) |
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121 | (1) |
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Study Questions and Exercises |
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122 | (3) |
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Appendix 3: Data for Study Questions 2 Through 5 |
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125 | (2) |
| Chapter 4 Descriptive Epidemiology: Person, Place, Time |
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127 | (52) |
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128 | (4) |
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Characteristics of Persons |
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132 | (20) |
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152 | (11) |
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163 | (6) |
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169 | (1) |
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Study Questions and Exercises |
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169 | (7) |
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Appendix 4: Project: Descriptive Epidemiology of a Selected Health Problem |
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176 | (3) |
| Chapter 5 Sources of Data for Use in Epidemiology |
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179 | (34) |
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180 | (1) |
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Criteria for the Quality and Utility of Epidemiologic Data |
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181 | (1) |
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Computerized Bibliographic Databases |
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182 | (1) |
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Confidentiality, Sharing of Data, and Record Linkage |
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182 | (8) |
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Statistics Derived from the Vital Registration System |
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190 | (1) |
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Reportable Disease Statistics |
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191 | (6) |
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197 | (1) |
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198 | (1) |
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Morbidity Surveys of the General Population |
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198 | (3) |
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201 | (2) |
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203 | (1) |
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Diseases Treated in Special Clinics and Hospitals |
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203 | (2) |
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Data from Physicians' Practices |
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205 | (1) |
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206 | (1) |
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206 | (1) |
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Morbidity in the Armed Forces: Data on Active Personnel and Veterans |
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207 | (1) |
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Other Sources of Data Relevant to Epidemiologic Studies |
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208 | (1) |
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209 | (1) |
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Study Questions and Exercises |
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209 | (4) |
| Chapter 6 Study Designs: Ecologic, Cross-Sectional, Case Control |
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213 | (40) |
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214 | (1) |
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Observational Versus Experimental Approaches in Epidemiology |
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215 | (1) |
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Overview of Study Designs Used in Epidemiology |
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216 | (4) |
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220 | (7) |
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227 | (7) |
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234 | (13) |
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247 | (1) |
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Study Questions and Exercises |
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248 | (5) |
| Chapter 7 Study Designs: Cohort Studies |
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253 | (42) |
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254 | (1) |
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254 | (10) |
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Sampling an Cohort Formation Options |
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264 | (5) |
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Temporal Differences in Cohort Designs |
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269 | (3) |
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272 | (4) |
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Measures of Interpretation and Examples |
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276 | (8) |
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Nested Case-Control Studies |
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284 | (2) |
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Summary of Cohort Studies |
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286 | (1) |
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Comparisons of Observational Designs |
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287 | (1) |
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287 | (3) |
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Study Questions and Exercises |
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290 | (5) |
| Chapter 8 Experimental Study Designs |
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295 | (32) |
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296 | (1) |
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Hierarchy of Study Designs |
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296 | (2) |
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298 | (1) |
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299 | (12) |
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311 | (10) |
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321 | (2) |
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Study Questions and Exercises |
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323 | (4) |
| Chapter 9 Measures of Effect |
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327 | (18) |
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328 | (1) |
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328 | (3) |
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331 | (5) |
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Statistical Measures of Effect |
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336 | (3) |
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Evaluating Epidemiologic Associations |
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339 | (2) |
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341 | (1) |
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Study Questions and Exercises |
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342 | (2) |
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Appendix 9: Cohort Study Data for Coffee Use and Anxiety |
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344 | (1) |
| Chapter 10 Data Interpretation Issues |
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345 | (24) |
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346 | (1) |
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Validity of Study Designs |
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346 | (4) |
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Sources of Error in Epidemiologic Research |
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350 | (5) |
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Techniques to Reduce Bias |
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355 | (3) |
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Methods To Control Confounding |
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358 | (4) |
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Bias in Analysis and Publication |
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362 | (1) |
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363 | (1) |
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Study Questions and Exercises |
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364 | (5) |
| Chapter 11 Screening for Disease in the Community |
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369 | (28) |
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370 | (1) |
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370 | (4) |
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Appropriate Situations for Screening Tests and Programs |
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374 | (3) |
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Characteristics of a Good Screening Test |
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377 | (1) |
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Evaluation of Screening Tests |
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377 | (4) |
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Sources of Unreliability and Invalidity |
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381 | (1) |
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Measures of the Validity of Screening Tests |
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382 | (2) |
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Effects of Prevalence of Disease on Screening Test Results |
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384 | (2) |
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Relationship Between Sensitivity and Specificity |
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386 | (2) |
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Evaluation of Screening Programs |
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388 | (1) |
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Issues in the Classification of Morbidity and Mortality |
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389 | (3) |
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392 | (1) |
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Study Questions and Exercises |
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392 | (4) |
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Appendix 11: Data for Problem 6 |
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396 | (1) |
| Chapter 12 Epidemiology of Infectious Diseases |
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397 | (48) |
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398 | (1) |
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Agents of Infectious Disease |
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399 | (2) |
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Characteristics of Infectious Disease Agents |
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401 | (3) |
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404 | (1) |
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Means of Transmission-Directly or Indirectly from Reservoir |
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405 | (6) |
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Measures of Disease Outbreaks |
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411 | (4) |
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Procedures Used in the Investigation of Infectious Disease Outbreaks |
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415 | (22) |
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Epidemiologically Significant Infectious Diseases in the Community |
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437 | (4) |
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Study Questions and Exercises |
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441 | (3) |
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Appendix 12: Data from a Foodborne Illness Outbreak in a College Cafeteria |
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444 | (1) |
| Chapter 13 Epidemiologic Aspects of Work and the Environment |
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445 | (30) |
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446 | (1) |
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Health Effects Associated with Environmental Hazards |
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447 | (1) |
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Study Designs Used in Environmental Epidemiology |
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447 | (3) |
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Toxicologic Concepts Related to Environmental Epidemiology |
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450 | (2) |
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452 | (6) |
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Environmental Hazards Found in the Work Setting |
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458 | (2) |
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Noteworthy Community Environmental Health Hazards |
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460 | (8) |
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468 | (1) |
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Study Questions and Exercises |
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468 | (7) |
| Chapter 14 Molecular and Genetic Epidemiology |
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475 | (38) |
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476 | (1) |
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Definitions and Distinctions: Molecular Versus Genetic Epidemiology |
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477 | (8) |
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Epidemiologic Evidence for Genetic Factors |
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485 | (1) |
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Causes of Familial Aggregation |
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485 | (2) |
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Shared Family Environment and Familial Aggregation |
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487 | (3) |
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Gene Mapping: Segregation and Linkage Analysis |
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490 | (7) |
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Application of Genes in Epidemiologic Designs |
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497 | (7) |
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Genetics and Public Health |
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504 | (3) |
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507 | (1) |
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Study Questions and Exercises |
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507 | (6) |
| Chapter 15 Psychologic, Behavioral, and Social Epidemiology |
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513 | (38) |
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514 | (4) |
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Research Designs Used in Psychologic, Behavioral, and Social Epidemiology |
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518 | (1) |
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The Social Context of Health |
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519 | (1) |
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520 | (6) |
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Moderating Factors in the Stress-Illness Relationship |
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526 | (11) |
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Outcome Variables: Physical Health, Mental Health, Affective States |
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537 | (6) |
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543 | (1) |
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Study Questions and Exercises |
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543 | (8) |
| Appendix A-Guide to the Critical Appraisal of an Epidemiologic/Public Health Research Article |
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551 | (6) |
| Appendix B-Answers to Selected Study Questions |
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557 | (10) |
| Glossary |
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567 | (18) |
| Index |
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585 | |