| Preface |
|
xiii | |
| Acknowledgments |
|
xv | |
| List of Symbols |
|
xvii | |
| Section 1 Background and History |
|
|
Chapter 1. Airborne Disease and the Indoor Environment |
|
|
3 | (12) |
|
|
|
3 | (1) |
|
1.2. Airborne Disease Today |
|
|
3 | (3) |
|
1.3. The History of Airborne Disease |
|
|
6 | (6) |
|
1.4. The Future of Disease Control |
|
|
12 | (1) |
|
|
|
13 | (2) |
|
Chapter 2. Airborne Pathogens and Allergens |
|
|
15 | (26) |
|
|
|
15 | (1) |
|
2.2. Airborne Pathogens and Allergens |
|
|
15 | (1) |
|
|
|
16 | (2) |
|
|
|
18 | (1) |
|
|
|
19 | (1) |
|
|
|
20 | (1) |
|
|
|
20 | (1) |
|
|
|
21 | (2) |
|
2.9. Dust Mites and Storage Mites |
|
|
23 | (1) |
|
2.10. Cockroach Allergens |
|
|
24 | (1) |
|
|
|
25 | (1) |
|
|
|
26 | (1) |
|
2.13. Microbial Volatile Organic Compounds |
|
|
27 | (2) |
|
2.14. Potential and Emerging Airborne Pathogens |
|
|
29 | (1) |
|
2.15. Airborne Biological Weapons |
|
|
29 | (1) |
|
2.16. The Airborne Pathogen and Allergen Database |
|
|
30 | (2) |
|
|
|
32 | (9) |
|
Chapter 3. The Pathology of Airborne Disease |
|
|
41 | (26) |
|
|
|
41 | (1) |
|
3.2. The Human Respiratory System |
|
|
41 | (3) |
|
3.3. Mechanisms of Lung Infection |
|
|
44 | (2) |
|
|
|
46 | (2) |
|
3.5. Airborne Respiratory Infections |
|
|
48 | (1) |
|
3.6. Upper Respiratory Tract Infections |
|
|
48 | (1) |
|
3.7. Middle Respiratory Tract Infections |
|
|
49 | (1) |
|
3.8. Lower Respiratory Tract Infections |
|
|
50 | (1) |
|
3.9. Noninfectious Respiratory Diseases |
|
|
51 | (10) |
|
3.10. Nosocomial and Opportunistic Respiratory Diseases |
|
|
61 | (1) |
|
3.11. Nonrespiratory Airborne Diseases |
|
|
62 | (1) |
|
|
|
63 | (1) |
|
|
|
63 | (4) |
|
Chapter 4. Epidemiology and Dosimetry |
|
|
67 | (32) |
|
|
|
67 | (1) |
|
4.2. Airborne Disease Statistics |
|
|
67 | (2) |
|
4.3. Routes of Transmission |
|
|
69 | (13) |
|
4.4. The Epidemiology of Airborne Diseases |
|
|
82 | (5) |
|
4.5. Disease Progression Curves |
|
|
87 | (3) |
|
4.6. Dosimetry of Airborne Disease |
|
|
90 | (4) |
|
4.7. Microbial Agent Ingestion Dosimetry |
|
|
94 | (1) |
|
|
|
94 | (1) |
|
|
|
95 | (4) |
|
Chapter 5. Aerobiology of the Outdoors |
|
|
99 | (20) |
|
|
|
99 | (1) |
|
5.2. Outdoor Pathogens and Allergens |
|
|
99 | (5) |
|
5.3. Outdoor Pathogenic Disease |
|
|
104 | (2) |
|
5.4. Fungal Allergies and Outdoor Air |
|
|
106 | (2) |
|
5.5. Pollen Allergies in Outdoor Air |
|
|
108 | (2) |
|
5.6. Other Allergies in Outdoor Air |
|
|
110 | (1) |
|
5.7. Asthma and Outdoor Air |
|
|
110 | (1) |
|
5.8. Outdoor Airborne Animal Diseases |
|
|
111 | (1) |
|
5.9. Survival of Microorganisms in the Environment |
|
|
112 | (3) |
|
|
|
115 | (4) |
|
Chapter 6. Aerosol Science and Particle Dynamics |
|
|
119 | (24) |
|
|
|
119 | (1) |
|
6.2. Size and Shape of Bioaerosols |
|
|
119 | (1) |
|
6.3. Surface Characteristics |
|
|
120 | (2) |
|
|
|
122 | (1) |
|
6.5. Aerodynamic Diameter |
|
|
122 | (1) |
|
|
|
123 | (3) |
|
|
|
126 | (1) |
|
|
|
126 | (4) |
|
|
|
130 | (7) |
|
6.10. Settling and Evaporation of Bioaerosols |
|
|
137 | (2) |
|
6.11. Bioaerosol Viability |
|
|
139 | (1) |
|
|
|
140 | (3) |
|
Chapter 7. Microbial Disinfection Fundamentals |
|
|
143 | (22) |
|
|
|
143 | (1) |
|
7.2. The Classic Exponential Growth Model |
|
|
143 | (2) |
|
7.3. The Classic Exponential Decay Model |
|
|
145 | (3) |
|
7.4. The Classic Two-Stage Decay Model |
|
|
148 | (1) |
|
7.5. The Classic Shoulder Model |
|
|
148 | (3) |
|
7.6. The Multihit Target Model |
|
|
151 | (2) |
|
7.7. Recovery and Photoreactivation |
|
|
153 | (1) |
|
7.8. Specific Disinfection Models |
|
|
153 | (8) |
|
|
|
161 | (1) |
|
|
|
162 | (3) |
|
Chapter 8. Buildings and Enclosures |
|
|
165 | (20) |
|
|
|
165 | (1) |
|
8.2. The Evolution of Human Habitats |
|
|
166 | (2) |
|
|
|
168 | (1) |
|
8.4. Building Airtightness |
|
|
169 | (1) |
|
|
|
170 | (2) |
|
|
|
172 | (7) |
|
|
|
179 | (6) |
| Section 2 Airborne Disease Control Technologies |
|
|
Chapter 9. Ventilation Systems and Dilution |
|
|
185 | (22) |
|
|
|
185 | (1) |
|
9.2. Ventilation System Types |
|
|
185 | (4) |
|
9.3. Biocontamination in Ventilation Systems |
|
|
189 | (2) |
|
9.4. Pressurization Control |
|
|
191 | (1) |
|
9.5. Dilution Ventilation |
|
|
191 | (1) |
|
9.6. The Single-Zone Steady-State Model |
|
|
192 | (3) |
|
9.7. Dilution Modeling with Calculus |
|
|
195 | (2) |
|
9.8. Single-Zone Transient Modeling |
|
|
197 | (4) |
|
|
|
201 | (3) |
|
9.10. Computational Fluid Dynamics Modeling |
|
|
204 | (1) |
|
|
|
204 | (3) |
|
Chapter 10. Filtration of Airborne Microorganisms |
|
|
207 | (24) |
|
|
|
207 | (1) |
|
10.2. Filter Performance Curves |
|
|
207 | (3) |
|
10.3. MERV Filter Ratings |
|
|
210 | (2) |
|
10.4. Modeling Filter Performance |
|
|
212 | (1) |
|
10.5. Mathematical Model of Filtration |
|
|
212 | (3) |
|
10.6. The Multifiber Filtration Model |
|
|
215 | (2) |
|
10.7. Fitting the Models to MERV Data |
|
|
217 | (4) |
|
10.8. Microbial Filtration Test Results |
|
|
221 | (3) |
|
10.9. Filter Application Test Results |
|
|
224 | (3) |
|
10.10. Special Filter Types |
|
|
227 | (1) |
|
|
|
227 | (4) |
|
Chapter 11. Ultraviolet Germicidal Irradiation |
|
|
231 | (36) |
|
|
|
231 | (1) |
|
11.2. Types of UVGI Systems |
|
|
231 | (4) |
|
11.3. UVGI Disinfection Theory |
|
|
235 | (2) |
|
11.4. UVGI Disinfection Modeling |
|
|
237 | (3) |
|
11.5. Modeling the UV Dose |
|
|
240 | (3) |
|
|
|
243 | (1) |
|
11.7. The UVGI Rating Value |
|
|
243 | (1) |
|
11.8. UV Irradiance Field Due to Enclosure Reflectivity |
|
|
243 | (5) |
|
|
|
248 | (1) |
|
11.10. Relative Humidity Effects |
|
|
249 | (1) |
|
|
|
250 | (1) |
|
11.12. Air Temperature Effects |
|
|
251 | (1) |
|
11.13. Performance Optimization |
|
|
252 | (3) |
|
11.14. Cooling Coil Irradiation |
|
|
255 | (1) |
|
|
|
256 | (1) |
|
11.16. UVGI Performance in Field Trials |
|
|
257 | (3) |
|
11.17. Combined Performance of UVGI and Filtration |
|
|
260 | (2) |
|
|
|
262 | (5) |
|
Chapter 12. Gas Phase Filtration |
|
|
267 | (14) |
|
|
|
267 | (1) |
|
12.2. Aerobiological Applications of Gas Phase Filtration |
|
|
268 | (1) |
|
12.3. Types of Gas Phase Filters |
|
|
269 | (1) |
|
|
|
270 | (4) |
|
|
|
274 | (1) |
|
12.6. Effect on Microbiological Particles |
|
|
275 | (1) |
|
12.7. Operation and Maintenance |
|
|
275 | (1) |
|
|
|
276 | (3) |
|
|
|
279 | (2) |
|
Chapter 13. Electrostatic Filtration |
|
|
281 | (14) |
|
|
|
281 | (1) |
|
13.2. Electrostatic Precipitation |
|
|
281 | (4) |
|
13.3. Electronic Air Cleaners |
|
|
285 | (1) |
|
13.4. Electrostatic Filters |
|
|
286 | (1) |
|
|
|
287 | (1) |
|
13.6. Electrically Enhanced Filtration |
|
|
287 | (2) |
|
13.7. Corona Wind Air Cleaners |
|
|
289 | (2) |
|
13.8. Aerobiological Performance of ESPs |
|
|
291 | (1) |
|
13.9. Economics of Electrostatic Filters |
|
|
292 | (1) |
|
|
|
292 | (3) |
|
Chapter 14. Photocatalytic Oxidation |
|
|
295 | (12) |
|
|
|
295 | (1) |
|
14.2. PCO Theory and Operation |
|
|
295 | (2) |
|
|
|
297 | (4) |
|
14.4. Destruction of MVOCs |
|
|
301 | (1) |
|
14.5. Surface Disinfection |
|
|
302 | (1) |
|
|
|
302 | (1) |
|
|
|
303 | (4) |
|
|
|
307 | (16) |
|
|
|
307 | (1) |
|
15.2. Pulsed White Light and Pulsed UV |
|
|
307 | (9) |
|
15.3. Filtered Pulsed Light |
|
|
316 | (1) |
|
15.4. Pulsed Electric Fields |
|
|
317 | (1) |
|
|
|
318 | (1) |
|
|
|
319 | (4) |
|
|
|
323 | (10) |
|
|
|
323 | (1) |
|
|
|
323 | (1) |
|
16.3. Ionization Equipment |
|
|
324 | (2) |
|
16.4. Ionization of Airborne Microbes |
|
|
326 | (4) |
|
16.5. Ionization of MVOCs |
|
|
330 | (1) |
|
|
|
330 | (3) |
|
|
|
333 | (16) |
|
|
|
333 | (1) |
|
|
|
333 | (3) |
|
17.3. Airborne Ozone Disinfection |
|
|
336 | (2) |
|
17.4. Ozone for Surface Sterilization |
|
|
338 | (1) |
|
|
|
339 | (1) |
|
17.6. Ozone Health Hazards |
|
|
340 | (1) |
|
17.7. Ozone System Performance |
|
|
340 | (4) |
|
|
|
344 | (5) |
|
Chapter 18. Green Technologies |
|
|
349 | (16) |
|
|
|
349 | (1) |
|
18.2. Passive Solar Exposure |
|
|
350 | (4) |
|
18.3. Vegetation Air Cleaning and Biofiltration |
|
|
354 | (2) |
|
18.4. Material Selectivity |
|
|
356 | (1) |
|
|
|
357 | (3) |
|
18.6. Aerobiologically Green Buildings |
|
|
360 | (3) |
|
|
|
363 | (2) |
|
Chapter 19. Thermal Disinfection, Cryogenics, and Desiccation |
|
|
365 | (6) |
|
|
|
365 | (1) |
|
19.2. Thermal Disinfection |
|
|
365 | (2) |
|
|
|
367 | (1) |
|
19.4. Desiccation and Dehumidification |
|
|
367 | (1) |
|
|
|
368 | (1) |
|
|
|
368 | (3) |
|
Chapter 20. Antimicrobial Coatings |
|
|
371 | (8) |
|
|
|
371 | (1) |
|
20.2. Performance of Materials |
|
|
372 | (3) |
|
20.3. Health Care and Pharmaceutical Applications |
|
|
375 | (1) |
|
20.4. Food Industry Applications |
|
|
375 | (1) |
|
20.5. Residential and Commercial Building Applications |
|
|
376 | (1) |
|
|
|
377 | (2) |
|
|
|
379 | (10) |
|
|
|
379 | (1) |
|
21.2. Microwave Thermal Disinfection |
|
|
379 | (4) |
|
21.3. Microwave Athermal Disinfection |
|
|
383 | (3) |
|
|
|
386 | (3) |
|
Chapter 22. Alternative and Developmental Technologies |
|
|
389 | (14) |
|
|
|
389 | (1) |
|
|
|
389 | (3) |
|
|
|
392 | (1) |
|
|
|
393 | (1) |
|
|
|
394 | (1) |
|
22.6. Chemical Disinfection |
|
|
395 | (2) |
|
|
|
397 | (1) |
|
|
|
397 | (6) |
| Section 3 Testing and Remediation |
|
|
Chapter 23. Air and Surface Sampling |
|
|
403 | (24) |
|
|
|
403 | (1) |
|
23.2. Air and Surface Microflora |
|
|
403 | (2) |
|
23.3. Growing Microbial Cultures |
|
|
405 | (3) |
|
|
|
408 | (1) |
|
|
|
409 | (5) |
|
23.6. Sampling Procedures |
|
|
414 | (7) |
|
23.7. Sampling Applications |
|
|
421 | (2) |
|
|
|
423 | (4) |
|
Chapter 24. Biodetection and Monitoring |
|
|
427 | (10) |
|
|
|
427 | (1) |
|
|
|
427 | (3) |
|
|
|
430 | (1) |
|
|
|
430 | (1) |
|
24.5. Polymerase Chain Reaction |
|
|
430 | (2) |
|
|
|
432 | (2) |
|
|
|
434 | (3) |
|
Chapter 25. Indoor Limits and Guidelines |
|
|
437 | (12) |
|
|
|
437 | (1) |
|
25.2. Indoor Bioaerosol Levels |
|
|
437 | (4) |
|
25.3. Indoor/Outdoor Ratios |
|
|
441 | (2) |
|
|
|
443 | (2) |
|
|
|
445 | (4) |
|
|
|
449 | (14) |
|
|
|
449 | (1) |
|
|
|
449 | (1) |
|
|
|
450 | (1) |
|
26.4. Removal of Building Materials |
|
|
451 | (1) |
|
26.5. Whole Building Decontamination |
|
|
451 | (3) |
|
26 6. Time and Weathering |
|
|
454 | (1) |
|
26.7. Mold Remediation Procedures |
|
|
454 | (2) |
|
26.8. Chemical Decontamination Procedures |
|
|
456 | (4) |
|
|
|
460 | (3) |
|
Chapter 27. Testing and Commissioning |
|
|
463 | (22) |
|
|
|
463 | (1) |
|
27.2. Ventilation System Testing |
|
|
463 | (1) |
|
21.3. Building Leak and Pressure Testing |
|
|
464 | (1) |
|
27.4. In-Place Filter Testing |
|
|
465 | (2) |
|
27.5. In-Place UVGI System Testing |
|
|
467 | (2) |
|
27.6. In-Place Testing of Surface Disinfection Systems |
|
|
469 | (5) |
|
27.7. In-Place Carbon Adsorber Testing |
|
|
474 | (1) |
|
27.8. Ventilation System Retrofit Testing |
|
|
475 | (1) |
|
|
|
475 | (2) |
|
21.10. Building Protection Factor |
|
|
477 | (3) |
|
|
|
480 | (5) |
| Section 4 Applications |
|
|
Chapter 28. Commercial Office Buildings |
|
|
485 | (12) |
|
|
|
485 | (1) |
|
28.2. Office Building Ventilation |
|
|
485 | (1) |
|
28.3. Office Building Epidemiology |
|
|
486 | (1) |
|
28.4. Office Building Aerobiology |
|
|
487 | (4) |
|
28.5. Standards and Guidelines |
|
|
491 | (1) |
|
28.6. Aerobiological Solutions |
|
|
491 | (3) |
|
|
|
494 | (3) |
|
Chapter 29. Educational Facilities |
|
|
497 | (14) |
|
|
|
497 | (1) |
|
29.2. Educational Buildings |
|
|
497 | (1) |
|
29.3. School Building Ventilation Systems |
|
|
498 | (1) |
|
29.4. School Building Epidemiology |
|
|
499 | (5) |
|
29.5. School Building Aerobiology |
|
|
504 | (2) |
|
29.6. School Building Solutions |
|
|
506 | (1) |
|
|
|
507 | (4) |
|
Chapter 30. Residential Housing |
|
|
511 | (16) |
|
|
|
511 | (1) |
|
|
|
511 | (5) |
|
30.3. Apartment Buildings |
|
|
516 | (1) |
|
30.4. Hotels and Dormitories |
|
|
516 | (1) |
|
30.5. Solutions for Homes and Apartments |
|
|
517 | (5) |
|
30.6. Solutions for Hotels |
|
|
522 | (1) |
|
30.7. Homes for the Immunocompromised |
|
|
522 | (2) |
|
|
|
524 | (3) |
|
Chapter 31. Health Care Facilities |
|
|
527 | (20) |
|
|
|
527 | (1) |
|
31.2. Guidelines, Codes, and Standards |
|
|
527 | (3) |
|
|
|
530 | (1) |
|
31.4. Airborne Nosocomial Epidemiology |
|
|
531 | (2) |
|
31.5. Nosocomial Aerobiology |
|
|
533 | (7) |
|
31.6. Nosocomial Control Options |
|
|
540 | (3) |
|
|
|
543 | (4) |
|
Chapter 32. Biological and Animal Laboratories |
|
|
547 | (20) |
|
|
|
547 | (1) |
|
32.2. Laboratory Guidelines |
|
|
547 | (3) |
|
32.3. Biological Laboratory Pathogens |
|
|
550 | (1) |
|
32.4. Animal Laboratory Pathogens |
|
|
550 | (1) |
|
32.5. Animal Laboratory Epidemiology |
|
|
551 | (5) |
|
32.6. Laboratory Air Cleaning |
|
|
556 | (3) |
|
32.7. Animal Laboratory Problems and Solutions |
|
|
559 | (4) |
|
|
|
563 | (4) |
|
Chapter 33. Food Industry Facilities |
|
|
567 | (18) |
|
|
|
567 | (1) |
|
33.2. Food Industry Codes and Standards |
|
|
567 | (1) |
|
33.3. Foodborne Pathogens and Allergens |
|
|
568 | (3) |
|
33.4. Food Industry Epidemiology |
|
|
571 | (3) |
|
33.5. Food Plant Aerobiology |
|
|
574 | (4) |
|
33.6. Food Plant Solutions |
|
|
578 | (2) |
|
|
|
580 | (5) |
|
Chapter 34. Agricultural and Animal Facilities |
|
|
585 | (18) |
|
|
|
585 | (1) |
|
34.2. Agricultural Pathogens and Allergens |
|
|
585 | (1) |
|
34.3. Agricultural Epidemiology |
|
|
586 | (4) |
|
34.4. Agricultural Aerobiology |
|
|
590 | (2) |
|
34.5. Ventilation and Solutions |
|
|
592 | (5) |
|
|
|
597 | (6) |
|
Chapter 35. Libraries and Museums |
|
|
603 | (16) |
|
|
|
603 | (1) |
|
|
|
603 | (7) |
|
|
|
610 | (5) |
|
|
|
615 | (4) |
|
Chapter 36. Places of Assembly |
|
|
619 | (8) |
|
|
|
619 | (1) |
|
36.2. Ventilation Systems |
|
|
619 | (3) |
|
|
|
622 | (1) |
|
|
|
623 | (2) |
|
|
|
625 | (2) |
|
Chapter 37. Aircraft and Transportation |
|
|
627 | (20) |
|
|
|
627 | (1) |
|
|
|
627 | (7) |
|
|
|
634 | (2) |
|
|
|
636 | (3) |
|
|
|
639 | (1) |
|
37.6. Cars, Buses, and Trains |
|
|
640 | (2) |
|
|
|
642 | (5) |
|
Chapter 38. Industrial Facilities |
|
|
647 | (24) |
|
|
|
647 | (1) |
|
38.2. Occupational Airborne Diseases |
|
|
647 | (6) |
|
38.3. Wood and Paper Industries |
|
|
653 | (4) |
|
38.4. Textile, Leather, and Fur Industries |
|
|
657 | (1) |
|
|
|
658 | (2) |
|
38.6. Biotechnology Industries |
|
|
660 | (1) |
|
38.7. Chemical and Mineral Industries |
|
|
661 | (1) |
|
38.8. Occupational Legionnaires' Disease |
|
|
662 | (1) |
|
38.9. Other Industries and Hazards |
|
|
663 | (1) |
|
38.10. Industrial Solutions |
|
|
664 | (1) |
|
|
|
665 | (6) |
|
Chapter 39. Sewage and Waste Processing |
|
|
671 | (12) |
|
|
|
671 | (1) |
|
39.2. Sewage and Waste Aerobiology |
|
|
671 | (3) |
|
39.3. Sewage and Waste Epidemiology |
|
|
674 | (4) |
|
39.4. Air Treatment Solutions |
|
|
678 | (2) |
|
|
|
680 | (3) |
| Appendix A: Airborne Pathogens and Allergens |
|
683 | (114) |
| Appendix B: Toxins and Associated Fungal Species |
|
797 | (4) |
| Appendix C: Microbial Volatile Organic Compounds |
|
801 | (4) |
| Appendix D: Surface Sampling Test Results Evaluation Form |
|
805 | (2) |
| Appendix E: Settle Plate Test Results Evaluation Form |
|
807 | (2) |
| Appendix F: Air Sampling Test Results Evaluation Form |
|
809 | (2) |
| Glossary |
|
811 | (10) |
| Index |
|
821 | |