| Preface |
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ix | |
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xi | |
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SECTION A: SCIENTIFIC FOUNDATIONS |
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Classification and Clinical Features of Movement Disorders |
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1 | (12) |
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Animal Models and the Science of Movement Disorders |
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13 | (20) |
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Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders |
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33 | (12) |
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Genetics of Spontaneous Mutations in Mice |
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45 | (10) |
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Assessment of Movement Disorders in Rodents |
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55 | (18) |
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Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals |
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73 | (28) |
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Behavior in Drosophila: Analysis and Control |
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101 | (10) |
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Use of C. elegans to Model Human Movement Disorders |
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111 | (16) |
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SECTION B: PARKINSON DISEASE |
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The Phenotypic Spectrum of Parkinson Disease |
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127 | (12) |
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MPTP-Induced Nigrostriatal Injury in Nonhuman Primates |
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139 | (10) |
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From Man to Mouse: The MPTP Model of Parkinson Disease |
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149 | (12) |
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Rotenone Rat and Other Neurotoxin Models of Parkinson Disease |
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161 | (12) |
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Drosophila Models of Parkinson Disease |
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173 | (10) |
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Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease |
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183 | (10) |
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Marie-Francoise Chesselet |
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Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease |
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193 | (16) |
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Motor Complications in Primate Models of Parkinson Disease |
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209 | (10) |
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C. elegans Models of Parkinson Disease |
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219 | (8) |
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Clinical Features and Classification of the Human Dystonias |
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227 | (14) |
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The Genetically Dystonic Rat |
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241 | (12) |
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Animal Models of Benign Essential Blepharospasm and Hemifacial Spasm |
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253 | (12) |
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265 | (14) |
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The Owl Monkey Model of Focal Dystonia |
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279 | (8) |
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287 | (6) |
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293 | (6) |
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SECTION D: HUNTINGTON DISEASE |
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Clinical and Pathological Characteristics of Huntington Disease |
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299 | (10) |
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Transgenic Rodent Models of Huntington Disease |
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309 | (8) |
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Knock-in and Knock-out Models of Huntington Disease |
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317 | (12) |
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Drosophila Models of Huntington Disease |
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329 | (6) |
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SECTION E: TREMOR DISORDERS |
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Neurophysiologic Characterization of Tremor |
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335 | (12) |
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347 | (14) |
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361 | (8) |
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GABAA Receptor α1 Subunit Knockout Mice: A Novel Model of Essential Tremor |
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369 | (8) |
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Production and Physiological Study of Holmes Tremor in Monkeys |
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377 | (16) |
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The Campus Syndrome in Pietrain Pigs |
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393 | (4) |
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Pathophysiology, Neurophysiology, and Pharmacology of Human Myoclonus |
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397 | (18) |
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Post-Hypoxic Myoclonus in Rodents |
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415 | (8) |
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Baboon Model of Myoclonus |
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423 | (8) |
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431 | (10) |
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Animal Models of Tourette Syndrome |
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441 | (8) |
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SECTION H: PAROXYSMAL MOVEMENT DISORDERS |
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Paroxysmal Dyskinesias in Humans |
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449 | (10) |
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The Genetically Dystonic Hamster: An Animal Model of Paroxysmal Dystonia |
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459 | (8) |
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Mouse Models of Hyperekplexia |
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467 | (12) |
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479 | (8) |
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Movement Disorders in Drosophila Mutants of Potassium Channels and Biogenic Amine Pathways |
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487 | (18) |
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SECTION I: PROGRESSIVE SUPRANUCLEAR PALSY AND CORTICOBASAL GANGLIONIC DEGENERATION |
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Progressive Supranuclear Palsy and Corticobasal Degeneration |
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505 | (10) |
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Genetic Susceptibility and Animal Modeling of PSP |
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515 | (14) |
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Rodent Models of Tauopathies |
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529 | (12) |
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SECTION J: MULTIPLE SYSTEM ATROPHY |
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Clinical Spectrum and Pathological Features of Multiple System Atrophy |
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541 | (30) |
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Double-Lesion Animal Models of Multiple System Atrophy |
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571 | (14) |
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A Mouse Model for Multiple System Atrophy |
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585 | (10) |
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Clinical and Pathological Features of Hereditary Ataxias |
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595 | (18) |
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613 | (10) |
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Animal Models of Spinocerebellar Ataxia Type 1 (SCA1) |
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623 | (8) |
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Spinocerebellar Ataxia Type 2 (SCA2) |
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631 | (6) |
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637 | (12) |
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Animal Models of Friedreich Ataxia |
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649 | (8) |
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Animal Oculomotor Data Illuminate Cerebellum-Related Eye Movement Disorders |
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657 | (22) |
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679 | (8) |
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Hereditary Spastic Paraplegia: Clinical Features and Animal Models |
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687 | (4) |
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The Spastic Rat with Sacral Spinal Cord Injury |
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691 | (8) |
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Rat Spinal Cord Contusion Model of Spasticity |
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699 | (14) |
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SECTION M: DRUG-INDUCED MOVEMENT DISORDERS |
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Drug-Induced Movement Disorders |
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713 | (12) |
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Neuroleptic-Induced Acute Dystonia and Tardive Dyskinesia in Primates |
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725 | (10) |
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Motor Effects of Typical and Atypical Antipsychotic Drugs in Rodents |
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735 | (10) |
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Animal Models of Drug-Induced Akathisia |
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745 | (10) |
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SECTION N: RESTLESS LEGS SYNDROME |
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Clinical Features and Animal Models of Restless Legs Syndrome and Periodic Limb Movement |
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755 | (4) |
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| Index |
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759 | |