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NUCLEOTIDES AND THEIR RECEPTORS IN THE NERVOUS SYSTEM,9780444500823
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NUCLEOTIDES AND THEIR RECEPTORS IN THE NERVOUS SYSTEM


Edition: 1st
Author(s): Illes; Zimmermann
ISBN10:  0444500820
ISBN13:  9780444500823
Format:  Hardcover
Pub. Date:  8/31/1999
Publisher(s): Elsevier Science & Technology

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SummaryTable of Contents
The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated.

Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides.

At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide.

An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.

Univ. of Leipzig, Germany. Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, on August 1-2, 1998. Offers a comprehensive overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes, and their physiological functions in the nervous system.
List of Contributors
v
Preface xi
Signalling via nucleotides in the nervous system
Current status of purinergic signalling in the nervous system
3(8)
G. Burnstock
Modulation of purinergic neurotransmission
11(12)
P. Sneddon
T. D. Westfall
L.D. Todorov
S. Mihaylova-Todorova
D.P. Westfall
C. Kennedy
Molecular biology of P2Y receptors
Molecular biology of P2Y receptors expressed in the nervous system
23(10)
T.E. Webb
E.A. Barnard
P2Y receptors in the nervous system: Molecular studies of a P2Y2 receptor subtype from NG108-15 neuroblastoma x glioma hybrid cells
33(12)
G.A. Weisman
R.C. Garrad
L.J. Erb
C. Santos-Berrios
F.A. Gonzalez
Nucleotide radiolabels as tools for studying P2Y receptors in membranes from brain and lung tissue
45(16)
G. Reiser
W. Laubinger
R. Schafer
Molecular biology of P2X receptors
Evolving view of quaternary structures of ligand-gated ion channels
61(20)
A. Nicke
J. Rettinger
C. Buttner
A. Eichele
G. Lambrecht
G. Schmalzing
Cloning, functional characterization and developmental expression of a P2X receptor from chick embryo
81(12)
A. Ruppelt
B.T. Liang
F. Soto
Development of neucleotide analogues
Developments in P2 receptor targeted therapeutics
93(14)
M. Williams
Novel ligands for P2 receptor subtypes in innervated tissues
107(12)
G. Lambrecht
S. Damer
B. Niebel
S. Czeche
P. Nickel
J. Rettinger
G. Schmalzing
E. Mutschler
Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis
119(16)
K.A. Jacobson
C. Hoffmann
Y.-C. Kim
E. Camaioni
E. Nandanan
S.Y. Jang
D.-P. Guo
X.-D. Ji
I. von Kugelgen
S. Moro
A.U. Ziganshin
A. Rychkov
B.F. King
S.G. Brown
S.S. Wildman
G. Burnstock
J.L. Boyer
A. Mohanram
T.K. Harden
Release of nucleotides
Release of ATP and UTP from astrocytoma cells
135(10)
T.K. Harden
E.R. Lazarowski
Quantal ATP release from motor nerve endings and its role in neurally mediated depression
145(14)
E.M. Silinsky
J.K. Hirsh
T.J. Searl
R.S. Redman
M. Watanabe
Receptor- and carrier-mediated release of ATP of postsynaptic origin: Cascade transmission
159(14)
E.S. Vizi
B. Sperlagh
Presynaptic modulation by nucleotides of neurotransmitter release
P2-receptors controlling neurotransmitter release from postganglionic sympathetic neurones
173(10)
I. von Kugelgen
W. Norenberg
H. Koch
A. Meyer
P. Illes
K. Starke
Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases
183(10)
A.M. Sebastiao
R.A. Cunha
J.F. Cascalheira
J.A. Ribeiro
The functions of ATP receptors in the synaptic transmission in the hippocampus
193(16)
K. Inoue
S. Koizumi
S. Ueno
A. Kita
M. Tsuda
Physiology of nucleotide function
Electrophysiological analysis of P2-receptor mechanisms in rat sympathetic neurones
209(14)
W. Norenberg
I. von Kugelgen
A. Meyer
P. Illes
P2 receptor-mediated activation of noradrenergic and dopaminergic neurons in the rat brain
223(14)
H. Kittner
U. Krugel
W. Poelchen
D. Sieler
R. Reinhardt
I. von Kugelgen
P. Illes
ATP receptor-mediated component of the excitatory synaptic transmission in the hippocampus
237(14)
Y. Pankratov
U. Lalo
E. Castro
M.T. Miras-Portugal
O. Krishtal
Nucleotide and dinucleotide effects on rates of paroxysmal depolarising bursts in rat hippocampus
251(14)
F.M. Ross
M.J. Brodie
T.W. Stone
Physiology of nucleoside function
The function of A2 adenosine receptors in the mammalian brain: Evidence for inhibition vs. enhancement of voltage gated calcium channels and neurotransmitter release
265(10)
F.A. Edwards
S.J. Robertson
An adenosine A3 receptor-selective agonist does not modulate calcium-activated potassium currents in hippocampal CA1 pyramidal neurons
275(12)
T.V. Dunwiddie
K.A. Jacobson
L. Diao
Brain hypoxia: Effects of ATP and adenosine
287(14)
K. Nieber
D. Eschke
A. Brand
Nucleotide effects on neuronal differentiation and glial proliferation
Adenosine and P2 receptors in PC12 cells. Genotypic, phenotypic and individual differences
301(10)
G. Arslan
B.B. Fredholm
Nucleotide receptor signalling in spinal cord astrocytes: Findings and functional implications
311(12)
C.J. Gallagher
M.W. Salter
Trophic signaling pathways activated by purinergic receptors in rat and human astroglia
323(10)
J.T. Neary
M. McCarthy
A. Cornell-Bell
Y. Kang
Signalling mechanisms involved in P2Y receptor-mediated reactive astrogliosis
333(12)
M.P. Abbracchio
R. Brambilla
S. Ceruti
F. Cattabeni
Immunomodulatory effects of ATP
Purinoceptors in human B-lymphocytes
345(10)
F. Markwardt
M. Klapperstuck
M. Lohn
D. Riemann
C. Buttner
G. Schmalzing
The P2Z/P2X7 receptor of microglial cells: A novel immunomodulatory receptor
355(16)
F. Di Virgilio
J.M. Sanz
P. Chiozzi
S. Falzoni
Ecto-nucleotidases and ecto-protein kinases
Ecto-nucleotidases - molecular structures, catalytic properties, and functional roles in the nervous system
371(16)
H. Zimmermann
N. Braun
Immunolocalization of ATP diphosphohydrolase in pig and mouse brains, and sensory organs of the mouse
387(10)
A.R. Beaudoin
G. Grondin
F.-P. Gendron
Diadenosine polyphosphates, extracellular function and catabolism
397(14)
M.T. Miras-Portugal
J. Gualix
J. Mateo
M. Diaz-Hernande
R. Gomez-Villafuertes
E. Castro
J. Pintor
Ecto-protein kinases as mediators for the action of secreted ATP in the brain
411(16)
Y.H. Ehrlich
E. Kornecki
Subject Index 427

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