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9780444504890

Channelopathies

by ;
  • ISBN13:

    9780444504890

  • ISBN10:

    0444504893

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2000-11-16
  • Publisher: Elsevier Science
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Supplemental Materials

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Summary

This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

Table of Contents

Foreword vii
E. Neher
Preface viii
F. Lehmann-Horn
K. Jurkat-Rott
List of Contributors
ix
Introduction xi
Muscle diseases
Sodium and calcium channelopathies of sarcolemma: periodic paralyses, paramyotonia congenita and potassium-aggravated myotonia
3(30)
N. Mitrovic
H. Lerche
Muscle chloride channelopathies: myotonia congenita
33(22)
R. Rudel
Molecular aspects of malignant hyperthermia and central core disease
55(30)
P.J. Lynch
T.V. McCarthy
Mutations affecting muscle nicotinic acetylcholine receptors and their role in congenital myasthenic syndromes
85(30)
D. Beeson
J. Newsom-Davis
Ion channel defects in primary electrical diseases of the heart
115(40)
G.E. Kirsch
Neuronal diseases
Migraine and ataxias
155(26)
A. Ducros
C. Denier
E. Tournier-Lasserve
Genetic analysis of idiopathic epilepsies: the role of ion channel mutations
181(18)
O.K. Steinlein
The inhibitory glycine receptor as a model of hereditary channelopathies
199(28)
K. Becker
C.-M. Becker
H.-G. Breitinger
Internal diseases
Cystic fibrosis
227(28)
R. Greger
Dent's disease: an hereditary nephrolithiasis caused by dysfunction of a voltage-gated chloride channel
255(22)
C. Fahlke
Liddle's syndrome and pseudohypoaldosteronism type I
277(22)
S. Grunder
The role of ATP-sensitive K+ channels in familial hyperinsulinism
299(28)
B. Glaser
L. Aguilar-Bryan
Hereditary hypokalemic salt-losing tubulopathies
327(28)
N. Jeck
M. Conrad
H.W. Seyberth
Overview
Table of known channelopathies 355(6)
Subject Index 361

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