| Contributors |
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Introduction to the immune system |
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Adaptive and innate immunity |
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1 | (1) |
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Cells of the immune system |
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2 | (3) |
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Soluble mediators of immunity |
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5 | (2) |
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7 | (1) |
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7 | (3) |
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10 | (1) |
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Defences against extracellular and intracellular pathogens |
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11 | (1) |
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11 | (1) |
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12 | (3) |
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Cells, tissues and organs of the immune system |
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Cells of the innate immune system |
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15 | (7) |
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Cells of the adaptive immune system |
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22 | (8) |
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30 | (12) |
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42 | (5) |
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Cell migration and inflammation |
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Mechanisms of cell migration |
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47 | (5) |
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Patterns of cell migration |
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52 | (1) |
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52 | (2) |
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54 | (7) |
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Auxiliary cells in acute inflammation |
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61 | (4) |
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Immunoglobulins-a family of proteins |
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65 | (6) |
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Interaction of antibodies with antigens |
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71 | (3) |
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74 | (2) |
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76 | (2) |
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Generation of antibody diversity |
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78 | (2) |
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Immunoglobulin gene recombination |
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80 | (3) |
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83 | (4) |
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T-cell receptors and major histocompatibility complex molecules |
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87 | (2) |
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Genes of the T-cell antigen receptor |
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89 | (2) |
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Major histocompatibility complex (MHC) molecules |
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91 | (2) |
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Interactions of MHC molecules with antigenic peptides |
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93 | (2) |
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Interaction of the T-cell receptor with MHC and antigen |
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95 | (2) |
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MHC genomic organization and expression |
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97 | (3) |
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Antigen presentation by CD1 |
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100 | (5) |
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105 | (1) |
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Antigen processing and presentation |
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106 | (6) |
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112 | (3) |
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115 | (4) |
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Cytokines and cytokine receptors |
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Cytokine and cytokine receptor families |
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119 | (4) |
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Mechanisms of cell activation |
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123 | (2) |
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Cytokine production by T-cell subsets |
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125 | (2) |
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127 | (4) |
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Cell cooperation in the antibody response |
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131 | (1) |
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Activation of B cells by T-independent antigens |
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132 | (2) |
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Activation of B cells by T-dependent antigens |
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134 | (4) |
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Activation and differentiation of B cells in the germinal centre |
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138 | (1) |
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Antibody responses in vivo |
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139 | (2) |
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Differentiation of B cells |
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141 | (7) |
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Mononuclear phagocytes in immune defence |
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Resident and mobile populations of macrophages |
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148 | (5) |
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153 | (4) |
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157 | (3) |
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160 | (4) |
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Cell-mediated cytotoxicity |
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Natural killer cell receptors |
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164 | (3) |
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Mechanisms of cytotoxicity |
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167 | (3) |
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Non-lymphoid cytotoxic effectors |
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170 | (3) |
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Regulation of the immune response |
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173 | (1) |
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The antigen-presenting cell |
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174 | (1) |
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175 | (1) |
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Regulation by lymphocytes |
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176 | (3) |
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Regulation by NK and NK T cells |
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179 | (1) |
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Regulation by localization of cells |
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179 | (1) |
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Idiotypic modulation of responses |
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180 | (1) |
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Neuroendocrine modulation of immune responses |
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181 | (1) |
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Genetic control of immune responses |
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182 | (9) |
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191 | (1) |
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Experimental induction of tolerance |
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192 | (1) |
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Central thymic tolerance to self antigens |
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192 | (6) |
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Peripheral or post-thymic tolerance to self antigens |
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198 | (5) |
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B-cell tolerance to self antigens |
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203 | (2) |
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Artificially induced tolerance in vivo |
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205 | (3) |
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Potential therapeutic applications of tolerance |
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208 | (3) |
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211 | (7) |
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218 | (8) |
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Lymphomyeloid tissues in lower vertebrates |
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226 | (3) |
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Amphibian models for studying ontogeny of immunity |
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229 | (6) |
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235 | (1) |
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Innate immune response to viruses |
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236 | (1) |
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Host defence involving B and T cells |
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237 | (2) |
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Strategies for evading immune defences |
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239 | (1) |
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240 | (5) |
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Immunity to bacteria and fungi |
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245 | (11) |
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256 | (3) |
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Immunity to protozoa and worms |
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Features of parasitic infections |
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259 | (2) |
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261 | (3) |
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Pivotal role of T cells in the development of immunity |
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264 | (6) |
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270 | (4) |
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Immunopathological consequences of parasitic infections |
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274 | (1) |
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275 | (2) |
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Antigens used as vaccines |
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277 | (4) |
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Effectiveness of vaccines |
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281 | (1) |
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282 | (1) |
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282 | (1) |
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283 | (1) |
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284 | (1) |
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285 | (1) |
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Non-specific immunotherapy |
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286 | (1) |
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Vaccinating against cancer |
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286 | (1) |
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286 | (3) |
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The tumour as a tissue graft |
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289 | (1) |
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289 | (2) |
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291 | (2) |
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Human tumour-associated antigens detected by immune cells |
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293 | (1) |
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Tumour-associated antigens detected by antibodies |
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294 | (2) |
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296 | (1) |
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297 | (2) |
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299 | (1) |
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300 | (3) |
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303 | (1) |
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304 | (4) |
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Defects in complement proteins |
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308 | (1) |
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309 | (4) |
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Secondary immunodeficiency |
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Immunodeficiency caused by drugs |
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313 | (2) |
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Nutrition and immune responses |
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315 | (2) |
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317 | (7) |
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Immediate hypersensitivity |
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324 | (1) |
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325 | (1) |
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Role of T cells in the immune response to inhalant allergens |
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326 | (2) |
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Allergens: the antigens that give rise to immediate hypersensitivity |
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328 | (2) |
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330 | (3) |
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Genetics of allergic disease |
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333 | (1) |
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Skin tests for diagnosis and investigation |
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334 | (2) |
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Factors that influence the symptoms of allergic disease |
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336 | (2) |
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Asthma and bronchial reactions to inhaled antigens |
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338 | (1) |
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Immunotherapy with allergen extracts |
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339 | (1) |
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New treatments for allergic disease |
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340 | (1) |
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The biological role of IgE |
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341 | (4) |
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345 | (1) |
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Reactions against blood cells and platelets |
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346 | (5) |
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Reactions against tissue antigens |
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351 | (6) |
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Hypersensitivity-Type III |
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Types of immune-complex disease |
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357 | (1) |
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Mechanisms in Type III hypersensitivity |
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358 | (1) |
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Experimental models of immune-complex disease |
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359 | (2) |
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361 | (3) |
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Deposition of complexes in tissues |
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364 | (3) |
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Detection of immune complexes |
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367 | (4) |
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371 | (3) |
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Tuberculin-type hypersensitivity |
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374 | (2) |
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Granulomatous hypersensitivity |
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376 | (1) |
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Cellular reactions in Type IV hypersensitivity |
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377 | (1) |
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Diseases manifesting type IV granulomatous hypersensitivity |
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378 | (7) |
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Transplantation and rejection |
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Barriers to transplantation |
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385 | (1) |
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Histocompatibility antigens |
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386 | (1) |
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The laws of transplantation |
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387 | (1) |
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The role of T lymphocytes in rejection |
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387 | (3) |
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390 | (2) |
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Genetic predisposition to graft rejection |
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392 | (2) |
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394 | (7) |
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Autoimmunity and autoimmune disease |
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The association of autoimmunity with disease |
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401 | (1) |
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The spectrum of autoimmune diseases |
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401 | (1) |
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402 | (1) |
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403 | (4) |
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407 | (5) |
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Diagnostic and prognostic value of autoantibodies |
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412 | (1) |
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412 | (5) |
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Antigen-antibody interactions |
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417 | (6) |
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Isolation of pure antibodies |
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423 | (3) |
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426 | (1) |
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Assays for circulating immune complexes |
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427 | (1) |
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Isolation of lymphocyte populations |
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427 | (2) |
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429 | (4) |
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Gene targeting and transgenic animals |
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433 | (2) |
| Appendices |
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1: Major histocompatibility complex |
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435 | (2) |
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437 | (4) |
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441 | (2) |
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4: Chemokine receptors and chemokines |
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443 | (2) |
| Glossary |
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445 | (8) |
| Explanations for critical thinking and case studies |
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453 | (12) |
| Index |
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465 | |
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