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Introduction to Epidemiology,9780763735821
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Introduction to Epidemiology


Edition: 4th
Author(s): Merrill, Ray M.
ISBN10:  0763735825
ISBN13:  9780763735821
Format:  Paperback
Pub. Date:  1/27/2006
Publisher(s): Jones & Bartlett
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Table of Contents
About the Authors x
Preface xi
Preface to the Fourth Edition xiii
Foreword xv
Foundations of Epidemiology
1(22)
Objectives
1(1)
Introduction
2(1)
Activities in Epidemiology
3(1)
Role of Epidemiology in Public Health Practice
4(1)
Epidemics, Endemics, and Pandemics
5(2)
Case Concepts in Epidemiology
7(1)
The Epidemiology Triangle
8(2)
Some Disease Transmission Concepts
10(1)
Modes of Disease Transmission
11(1)
Chain of Infection
12(2)
Advanced Triangle of Epidemiology
14(1)
Levels of Prevention
14(4)
Summary
18(1)
Exercises
18(2)
References
20(3)
Historic Developments in Epidemiology
23(22)
Objectives
23(1)
Introduction
24(1)
Hippocrates, the First Epidemiologist
24(1)
Disease Observations of Sydenham
25(1)
The Epidemiology of Scurvy
26(1)
Cowpox and Its Epidemiologic Connection to Smallpox
26(1)
Epidemiology of Childbed Fever in a Lying-in Hospital
27(1)
John Snow's Investigation of Cholera in London
28(2)
Contribution of Pasteur and Koch to Epidemiology
30(2)
The Microscope and Its Contribution to Epidemiology
32(1)
John Graunt and Vital Statistics
33(1)
Ramazzini: Occupational Health and Industrial Hygiene
34(1)
Typhoid Mary
35(1)
Vitamins and the Cure of Nutritional Diseases
36(1)
Beginning of Epidemiology in the United States
37(2)
Historical Development of Morbidity in Epidemiology
39(1)
Framingham Heart Study
40(1)
Cigarette Smoking and Cancer
40(1)
Exercises
41(1)
References
42(3)
Practical Disease Concepts in Epidemiology
45(34)
Objectives
45(1)
Introduction
46(1)
Fundamentals of Communicable and Noncommunicable Diseases and Conditions
46(1)
Natural History of Disease
47(2)
Classifying Diseases
49(4)
Portals of Entry to the Human Body
53(1)
Incubation Periods for Selected Infectious Diseases
53(1)
Later Stages of Infection
54(3)
Zoonoses
57(1)
International Classification of Diseases
58(1)
Notifiable Diseases in the United States
59(1)
Protecting Public Health through Immunization
59(3)
Herd Immunity
62(1)
Communicable Disease Prevention and Control
63(3)
Host-Related Control and Prevention
66(1)
Infection Control and Prevention Measures
67(1)
Changing Emphasis in Epidemiologic Studies
67(2)
Nutritional Deficiency Diseases and Disorders
69(3)
Chronic Diseases and Conditions
72(3)
Health Goals in the United States for the Year 2010
75(1)
Exercises
76(1)
References
77(2)
Design Strategies and Statistical Methods in Descriptive Epidemiology
79(30)
Objectives
79(1)
Introduction
80(1)
Descriptive Study Designs
80(4)
Types of Data
84(1)
Ratios, Proportions, and Rates
85(7)
Tables, Graphs, and Numerical Measures
92(7)
Measures of Statistical Association
99(4)
Exercises
103(3)
References
106(3)
Descriptive Epidemiology According to Person, Place, and Time
109(32)
Objectives
109(1)
Introduction
110(1)
Person
110(14)
Place
124(1)
Time Trends
125(9)
Evaluation
134(1)
Causal Insights
135(2)
Exercises
137(1)
References
138(3)
General Health and Population Indicators
141(24)
Objectives
141(1)
Introduction
142(1)
Birth
142(1)
Mortality
143(4)
Types of Mortality Rates
147(1)
Infant Mortality
148(6)
Abortion Rate
154(1)
Maternal Mortality Rates
155(1)
Proportional Mortality Ratio
156(1)
Case Fatality Rate
156(1)
Years of Potential Life Lost
157(3)
Exercises
160(3)
References
163(2)
Design Strategies and Statistical Methods in Analytic Epidemiology
165(20)
Objectives
165(1)
Introduction
166(1)
Observational Epidemiologic Studies
166(1)
Case-Control Study Design
166(3)
Statistical Measures of Association
169(2)
Bias in Case-Control Studies
171(2)
Controlling for Bias in Case-Control Studies
173(1)
Strengths and Weaknesses of Case-Control Studies
174(1)
Cohort Studies
174(4)
Double-Cohort Studies
178(1)
Selecting the Study Cohort
178(1)
Bias in Cohort Studies
179(2)
Controlling for Bias in Cohort Studies
181(1)
Strengths and Weaknesses of Cohort Studies
181(1)
Effect Modification
181(2)
Exercises
183(1)
References
184(1)
Experimental Studies in Epidemiology
185(14)
Objectives
185(1)
Introduction
186(1)
Randomization
187(1)
Blinding
187(1)
Nonrandomization
188(1)
Designing a Randomized Controlled Trial
189(3)
Selected Special Types of Randomized Study Design
192(2)
Strengths and Weaknesses of Double-Blind Randomized Clinical Trials
194(1)
Ethics in Experimental Research
195(2)
Exercises
197(1)
References
197(2)
Statistical and Causal Associations
199(20)
Objectives
199(1)
Introduction
200(1)
Causal Associations
200(3)
Hypothesis Development and Testing
203(4)
Role of Bias
207(1)
Role of Confounding
207(1)
Factors in Causation of Disease
207(1)
Web of Causation
208(2)
Screening and Disease Detection
210(4)
Sensitivity and Specificity
214(2)
Exercises
216(2)
References
218(1)
Field Epidemiology
219(14)
Objectives
219(1)
Introduction
220(1)
Conducting a Field Investigation
220(6)
Steps in Working Up a Food-borne Illness Investigation
226(2)
Basic Epidemiologic Questions
228(2)
Exercises
230(1)
References
231(2)
Chronic Disease Epidemiology
233(24)
Objectives
233(1)
Introduction
234(1)
Chronic Disease Epidemiology
234(2)
Risk Factors
236(2)
Noninfectious Diseases and Conditions: Webs of Causation
238(5)
Descriptive Examples of Noninfectious Diseases and Conditions in the United States
243(5)
Prevention and Control
248(4)
Priorities in Disease Prevention and Control
252(1)
Health Belief Model in Epidemiology
252(1)
Exercises
253(1)
References
254(3)
Appendix I Case Studies
257(72)
Case Study I Snow on Cholera
259(24)
Observations on Cholera
259(4)
Case Study Questions
263(1)
Cholera and the Broad Street Outbreak
264(6)
Case Study Questions
270(1)
Cholera Epidemic of 1853 and Two London Water Companies
271(4)
Case Study Questions
275(1)
Epidemiological Issues
275(5)
Case Study Questions
280(3)
Case Study II Working through a Food-borne Illness Epidemic Investigation: Typhoid Fever in Schenectady
283(8)
Case of Typhoid Fever in Schenectady, New York
284(1)
Case Study Questions
284(7)
Case Study III Common-Source Outbreak of Waterborne Shigellosis at a Public School
291(8)
Case of Common-Source Outbreak of Waterborne Shigellosis at a Public School
291(5)
Case Study Questions
296(3)
Case Study IV Retrospective Analysis of Occupation and Alcohol-Related Mortality
299(4)
Case of Occupation and Alcohol-Related Causes of Death, California
299(2)
Case Study Questions
301(2)
Case Study V Retrospective Cohort Study of the Association of Congenital Malformations and Hazardous Waste
303(8)
Case on Congenital Malformations Associated with Proximity to Hazardous Waste Sites
304(3)
Case Study Questions
307(4)
Case Study VI History and Epidemiology of Polio Epidemics
311(18)
Brief Review of Poliomyelitis as It Is Known Today
312(1)
Case Study Questions
312(1)
First Polio Epidemics Studied and Reported: Sweden
313(6)
Case Study Questions
319(1)
First Major Epidemic of Poliomyelitis in America: Rutland, Vermont
320(1)
Case Study Questions
321(1)
Simon Flexner, MD, and Wade Hamilton Frost, MD: American Epidemiologists Who Investigated Poliomyelitis
321(3)
Case Study Questions
324(1)
Poliomyelitis Epidemic in Los Angeles, 1934
325(1)
Case Study Questions
326(1)
Epilogue
326(1)
References
327(2)
Appendix II Answers to Select Chapter Questions
329(10)
Appendix III Epidemiologic Associations and Societies
339(3)
Index 342

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