| Series Introduction |
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iii | (2) |
| Preface |
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v | (14) |
| Contributors to Plenary Sessions and Workshops |
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xix | |
| PLENARY SESSIONS |
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3 | (204) |
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1. Overview of the Clinical Use of Macrolides and Streptogramins |
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3 | (24) |
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2. Postantibiotic Effects and the Dosing of Macrolides, Azalides, and Streptogramins |
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27 | (12) |
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3. Ketolides: New Semisynthetic 14-Membered-Ring Macrolides |
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39 | (12) |
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4. Streptogramins: From Parenteral to Oral |
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51 | (16) |
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5. Azalides: Basic and Clinical Research |
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67 | (8) |
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6. Basic and Clinical Research on Macrolides |
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75 | (16) |
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7. Nonantibiotic Effects of Macrolide Antibiotics: Suppression of the Bacterial Glycocalyx of Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis |
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91 | (16) |
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8. Effects of Macrolides on Leukocytes and Inflammation |
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101 | (16) |
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9. Animal Uses of Macrolides and Related Antibiotics |
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117 | (14) |
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10. The New Macrolides for Treatment of Pediatric Infections: Roundtable Discussion |
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131 | (14) |
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11. The Molecular Mechanism of Action of Streptogramins and Related Antibiotics |
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145 | (28) |
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12. Early Clinical Results with Quinupristin/Dalfopristin for the Therapy of Bacteremia Due to Resistant Gram-Positive Bacteria |
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173 | (4) |
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Robert C. Moellering, Jr. |
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13. Drug Interactions of Macrolides and Azalides |
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177 | (12) |
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14. Macrolides, Azalides, and Streptogramins in Treatment of Opportunistic Infections in Immunocompromised Patients |
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189 | (18) |
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| WORKSHOPS |
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207 | (72) |
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15. Legionella and Spirochetes |
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207 | (12) |
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16. Mycoplasma and Chlamydia |
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219 | (6) |
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17. Staphylococci, Streptococci, and Pneumococci |
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225 | (8) |
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18. Pharmacokinetics and Pharmacodynamics |
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233 | (4) |
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19. Campylobacter and Helicobacter pylori |
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237 | (14) |
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20. Haemophilus influenzae, Enterococci, and Anaerobes |
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251 | (6) |
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21. The Newer Macrolides, Azalides, and Streptogramins for the Management of HIV-Associated Opportunistic Infections |
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257 | (10) |
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267 | (12) |
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| EXTENDED ABSTRACTS |
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279 | (396) |
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279 | (16) |
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Ketolides: A New Class of Macrolide Antibacterials--Structural Characteristics and Biological Properties of RU 004 |
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279 | (7) |
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Isolation of an Antifungal Macrolide from Soil Sample Nocardioides Strain: Production and Structure Elucidation |
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286 | (9) |
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II. LEGIONELLA, SPIROCHETES |
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295 | (22) |
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Azithromycin in the Treatment of Community-Acquired Legionnaires' Disease |
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295 | (4) |
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Temperature Dependence of MIC and MBC of Roxithromycin Against Borrelia burgdorferi In Vitro |
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299 | (4) |
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Tolerability of Treatment with 3 g of Azithromycin Given in 5 Days |
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303 | (4) |
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Azithromycin in the Treatment of Erythema Migrans |
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307 | (4) |
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Follow-up Study of Patients with Syphilis Treated with Azithromycin |
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311 | (6) |
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III. MYCOPLASMA, CHLAMYDIA |
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317 | (52) |
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A Comparison of the In Vitro Sensitivity of Chlamydia pneumoniae to Macrolides and a New Benzoxazinorifamycin, KRM-1648 |
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317 | (5) |
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Susceptibilities to Azithromycin of Isolates of Chlamydia pneumoniae from Patients with Community-Acquired Pneumonia |
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322 | (4) |
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Azithromycin in Control of Trachoma |
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326 | (4) |
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Microbiologic Efficacy of Azithromycin for the Treatment of Community-Acquired Pneumonia Due to Chlamydia pneumoniae in Children |
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330 | (5) |
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The Pediatric Pneumonia Study Group |
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Community-Acquired Pneumonia in Children: Underestimation of Mycoplasma Infection and Efficacy of Macrolides |
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335 | (4) |
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Ureaplasma urealyticum Isolations from Young Children with Respiratory Problems |
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339 | (4) |
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Could Clarithromycin Prevent Asthma? |
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343 | (6) |
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Azithromycin in the Treatment of Chlamydia trachomatis Infection |
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349 | (3) |
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Single-Dose Azithromycin in the Treatment of Genital Chlamydial Infections |
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352 | (2) |
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Single-Dose Azithromycin Treatment: A Solution for Uncomplicated Lower Genital Tract Chlamydial Infection |
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354 | (4) |
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Report of a Multicenter Clinical Evaluation of Azithromycin in the Treatment of Nongonococcal Urethritis in Men |
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358 | (3) |
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Efficacy of Roxithromycin in Urogenital Infection |
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361 | (8) |
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IV. STAPHYLOCOCCI, STREPTOCOCCI, PNEUMOCOCCI |
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369 | (70) |
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Dissociated Macrolide and Lincosamide Resistance in Streptococcus pneumoniae and Variation of Susceptibility Testing Methods in Detecting Clindamycin Resistance |
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369 | (7) |
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Prevalence of Antibiotic Resistance in Streptococcus pyogenes: Results of a National Multicenter Survey Conducted in Italy During 1995 |
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376 | (4) |
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In Vitro Activity of Some Macrolides Against S. pyogenes |
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380 | (5) |
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Antipneumococcal Activity of RP 59500 (an Injectable Streptogramin), Erythromycin, and Sparfloxacin by MIC and Rapid Time-Kill |
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385 | (5) |
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Effect of Macrolide Resistance on the Activity of the Oral Streptogramin RPR 106972 and Its Components Against Streptococcus pneumoniae |
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390 | (5) |
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In Vitro Antibacterial Activity of RU 004, a New Ketolide Active Against Respiratory Pathogens |
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395 | (7) |
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Antistaphylococcal Activity of Quinupristin/Dalfopristin, a Well-Defined Mixture of Chemically Modified Streptogramins |
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402 | (5) |
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E-Test for Susceptibility Testing of Streptococcus pyogenes to Azithromycin, Clarithromycin, Erythromycin, and Roxithromycin |
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407 | (4) |
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Efficacy of Clarithromycin Against Experimental Pulmonary Infection Caused by Streptococcus pneumoniae Strains with a Novel Macrolide Resistance Mechanism |
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411 | (4) |
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Macro- and Microautoradiographic Studies on Penetration of Azithromycin in Bacterially Infected Mice |
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415 | (6) |
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In Vivo Antibacterial Activity of RU 004, a New Ketolide Active Against Respiratory Pathogens |
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421 | (4) |
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Open Noncomparative Study of the Efficacy and Safety of Azithromycin in the Treatment of Adult Tonsilitis (Epidemiological Study of the Responsible Bacteria) |
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425 | (4) |
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An Open Study of Clarithromycin in the Treatment of Pneumonia Due to Streptococcus pneumoniae |
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429 | (3) |
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Clinical Study of Rokitamycin on Pneumococcal Upper Respiratory Tract Infections in Pediatrics |
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432 | (7) |
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V. PHARMACOKINETICS, PHARMACODYNAMICS, DRUG INTERACTIONS |
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439 | (48) |
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A Comparison of the Bronchopulmonary Pharmacokinetics of Clarithromycin and Azithromycin |
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439 | (8) |
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Kinetics of Dirithromycin: Concentrations in Tonsils, Bronchial Mucosa, and Secretions. Multiple-Dose Studies |
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447 | (8) |
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A Human Model of Local Abscess Using Skin Chambers: The Penetration of Azithromycin and the Chemiluminescence Response of Neutrophils (PMN) |
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455 | (5) |
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Separation of Presystemic and Post-Absorptive Influences on the Bioavailability of Azithromycin in Cynomolgus Monkeys |
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460 | (4) |
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Clinical Pharmacology of Azithromycin Given at Various Sites Along the Gastrointestinal Tract in Healthy Subjects |
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464 | (5) |
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Effect of Food and Formulation on Bioavailability of Azithromycin |
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469 | (5) |
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Rectal Azithromycin in Healthy Subjects |
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474 | (4) |
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Comparative Pharmacodynamics of Clarithromycin and Azithromycin Against Respiratory Tract Pathogens |
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478 | (9) |
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VI. HELICOBACTER PYLORI, CAMPYLOBACTER |
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487 | (18) |
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Comparison of Clarithromycin Efficacy in Ferrets and Humans for Treatment of Helicobacter-Induced Gastritis |
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487 | (6) |
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Azithromycin/Ranitidine Combined Treatment of Helicobacter pylori in Patients with Duodenal Ulcer and Chronic Gastritis: A Pilot Study |
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493 | (5) |
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Azithromycin as a Promising Part of Helicocidal Regiments |
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498 | (7) |
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VII. ANAEROBES, ENTEROCOCCI, HAEMOPHILUS INFLUENZAE |
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505 | (34) |
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Comparative In Vitro Activity of Five Macrolides Against Gram-Positive Cocci, Campylobacter Species, and Anaerobes |
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505 | (6) |
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Prophylactic Effect of Azithromycin on Experimentally Induced Intraabdominal Infection in Rats |
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511 | (5) |
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Are Macrolides Active Against Haemophilus influenzae? Are In Vitro Tests Reliable? |
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516 | (7) |
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Macrolide Susceptibility of Isolates of Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis from Patients with Community-Acquired Lower Respiratory Tract Infection--Results of an International Multicenter Study (the Alexander Project), 1992-1994 |
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523 | (5) |
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the Alexander Project Group |
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Resistance of Common Respiratory Pathogens to Erythromycin and Azithromycin |
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528 | (5) |
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Efficacy of Clarithromycin and Azithromycin at Human Pharmacological Dosage Against Experimental Haemophilus influenzae Pulmonary Infection |
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533 | (6) |
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VIII. MYCOBACTERIA AND OTHER INFECTIONS IN HIV-INFECTED PERSONS |
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539 | (16) |
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Clarithromycin 500 mg BID as Prophylaxis for MAC Disease--A Follow-up Review |
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539 | (5) |
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Clarithromycin Prophylaxis for Disseminated Mycobacterium avium Infection |
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544 | (5) |
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Azithromycin + Pentamidine + Pyrimethamine in the Prophylaxis of Opportunistic Infections in HIV-Positive Patients with CD4 Count Less Than 200 |
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549 | (6) |
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555 | (16) |
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Human and Animal Bite Wounds: Bacteriology, Macrolide Susceptibility, and Therapeutic Potential |
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555 | (4) |
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Azithromycin in the Treatment of Pertussis in Children: A Pilot Study |
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559 | (4) |
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The Use of New Macrolides in Experimental Brucella melitensis Infection |
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563 | (8) |
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X. NONANTIBACTERIAL EFFECTS |
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571 | (22) |
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In Vivo Effect of Azithromycin Subinhibitory Concentrations on the Mortality of Experimental Pseudomonas aeruginosa Sepsis |
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571 | (5) |
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Clarithromycin Reduces Cl-Dependent Transepithelial Potential Difference in Tracheal Mucosa of Anesthetized Rabbits |
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576 | (5) |
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Inhibition of Adherence of Klebsiella pneumoniae Strains to Intestine-407 Cell Lines by Roxithromycin |
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581 | (5) |
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Clinical and Immunological Study of Roxithromycin on Infectious Diseases in Obstetrics and Gynecology |
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586 | (7) |
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XI. CLINICAL STUDIES: OTITIS MEDIA |
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593 | (12) |
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Five-Day Treatment of Acute Otitis Media in Children with Clarithromycin |
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593 | (4) |
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Azithromycin Versus Amoxicillin for Acute Otitis Media Prophylaxis |
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597 | (8) |
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XII. CLINICAL STUDIES: BRONCHITIS |
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605 | (12) |
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Azithromycin for the Treatment of Community-Acquired Bronchitis: A Large Multicenter Efficacy-Tolerance Trial |
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605 | (4) |
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Safety and Efficacy of Clarithromycin Compared with Cefpodoxime Proxetil in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
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609 | (8) |
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XIII. CLINICAL STUDIES: PNEUMONIA |
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617 | (24) |
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Randomized Comparative Trial of the Safety, Efficacy, and Cost of Intravenous Cefuroxime Plus Intravenous Erythromycin Versus Intravenous Cefuroxime Plus Oral Clarithromycin in the Therapy of Community-Acquired Pneumonia |
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617 | (9) |
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Azithromycin in the Treatment of Community-Acquired Pneumonia |
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626 | (3) |
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Azithromycin: 3-Day Versus 5-Day Dosage Regimen for Community-Acquired Pneumonia in Children |
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629 | (5) |
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Single-Dose Azithromycin in the Treatment of Atypical Pneumonia: A Pilot Study |
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634 | (7) |
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XIV. CLINICAL STUDIES: OTHER RESPIRATORY INFECTIONS |
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641 | (30) |
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Azithromycin in the Treatment of Patients with Upper Respiratory Tract Infections, Comparison of 3-Day and 5-Day Regimens |
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641 | (4) |
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Clinical and Bacteriological Evaluation of Clarithromycin (50-mg Tablets) in Children with Lower Respiratory Tract Infection |
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645 | (4) |
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Experience with Improved Compliance of Clarithromycin Granules in Children |
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649 | (7) |
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Efficacy and Tolerability of Azithromycin Versus Josamycin in the Treatment of Children with Lower Respiratory Tract Infections |
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656 | (4) |
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Azithromycin in the Treatment of Respiratory Tract Infections in Children |
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660 | (4) |
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Efficacy of Roxithromycin in Elderly and Middle-Aged Patients with Respiratory Tract Infections |
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664 | (7) |
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XV. OTHER CLINICAL STUDIES |
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671 | (4) |
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Experience with Azithromycin as Prophylaxis in Transrectal Biopsy of the Prostate |
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671 | (4) |
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| Author Index |
|
675 | (6) |
| Subject Index |
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681 | |
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