| Preface |
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iii | (1) |
| Contributors |
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I. Utilization: Economic and Regulatory Issues |
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1 | (36) |
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1. The Impact of Blood Substitutes on Blood Banking Worldwide |
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1 | (16) |
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2. Potential Use of Red Blood Cell Substitutes Within the Military |
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17 | (12) |
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3. Blood Substitutes: Unique Regulatory Aspects |
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29 | (8) |
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II. Fundamental Principles of Oxygen Transport |
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37 | (128) |
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4. Oxygen Transport, Oxygen Carriers, and the Transfusion Trigger |
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37 | (32) |
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5. Microcirculatory Consequences of Blood Substitution with Hemoglobin Solutions |
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69 | (10) |
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6. Efficacy of Perflubron-Based Emulsion as a Temporary Oxygen Carrier |
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79 | (40) |
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7. Human Recombinant Hemoglobin as a Safe and Effective Mode of Volume Replacement in a Large Animal Model of Hemorrhagic, Hypovolemic, Oxygen Debt Shock |
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119 | (46) |
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III. Interactions with Organ Systems |
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165 | (70) |
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8. Immunological Alterations Following Hemorrhagic Shock: Considerations for Resuscitation with Blood Substitutes |
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165 | (24) |
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9. Renal Effects of Hemoglobin-Based Blood Substitutes |
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189 | (30) |
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10. Interactions of Hemoglobin with the Central Nervous System |
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219 | (16) |
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IV. Interactions with Molecular Species |
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235 | (28) |
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11. Interactions Between Hemoglobin and Bacterial Endotoxin In Vitro and In Vivo |
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235 | (28) |
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V. Alternative Strategies and Indications |
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263 | (62) |
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12. Encapsulation of Hemoglobin in Liposomes |
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263 | (24) |
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13. The Use of Blood Substitutes in Tumor Therapy |
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287 | (22) |
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14. Human Hemoglobin Derived from Transgenic Swine: A Starting Material for "Blood Substitute" Formulations |
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309 | (16) |
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325 | (140) |
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15. Optro(TM) (Recombinant Human Hemoglobin): A Therapeutic for the Delivery of Oxygen and the Restoration of Blood Volume in the Treatment of Acute Blood Loss in Trauma and Surgery |
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325 | (10) |
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16. Production, Characterization, and Clinical Evaluation of Hemolink(TM), an Oxidized Raffinose Cross-Linked Hemoglobin-Based Blood Substitute |
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335 | (18) |
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17. HemAssist(TM): Development and Clinical Profile |
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353 | (48) |
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18. The Clinical Development of Human Polymerized Hemoglobin |
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401 | (20) |
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19. Use of HBOC-201 as an Oxygen Therapeutic in the Preclinical and Clinical Settings |
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421 | (16) |
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20. Medical and Therapeutic Applications of Perfluorocarbon-Based Products |
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437 | (28) |
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465 | (10) |
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21. Future Perspectives of Red Blood Cell Substitutes |
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465 | (10) |
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| Index |
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475 | |
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