| Series Introduction |
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iii | (4) |
| Preface |
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vii | (8) |
| Contributors |
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xv | |
| I. Chemistry, Biochemistry, and Cell Biology |
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1 | (144) |
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1. An Overview of Lipoate Chemistry |
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1 | (32) |
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2. Lipoate Redox Function in Chemical Systems |
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33 | (14) |
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3. Reaction of Lipoate and Its Derivatives with Reactive Oxygen Species |
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47 | (20) |
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4. Overview of the Role of Lipoate in the Enzyme Complexes of Energy Metabolism and Reducing Equivalents |
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67 | (20) |
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5. Alpha-Lipoic Acid Stimulates Glucose Transport into Muscle and Adipose Cells in Culture: Comparison with the Actions of Insulin and Dinitrophenol |
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87 | (12) |
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6. Lipoic Acid and the Redox Regulation of Apoptosis |
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99 | (14) |
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7. Lipoate Modulation of Lymphocyte Cysteine Uptake |
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113 | (18) |
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8. Lipoate Effects in an Animal-Free Model |
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131 | (14) |
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| II. Pathophysiological Conditions |
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145 | (192) |
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9. Tissue-Specific Pathways of XXX-Lipoate Reduction in Mammalian Systems |
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145 | (18) |
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10. XXX-Lipoate: Antioxidant Properties and Effects on Skin |
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163 | (18) |
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11. Suppression of Radiation-Induced Free Radical-Mediated Cellular Damage by Lipoate |
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181 | (12) |
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12. Protection from Myocardial Ischemia Reperfusion Injury |
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193 | (12) |
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13. Neuroprotective Activity of Lipoic and Dihydrolipoic Acid |
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205 | (22) |
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14. XXX-Lipoic Acid and Cataract Risk Reduction |
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227 | (16) |
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15. Metabolic Alterations in Non-Insulin-Dependent Diabetes Mellitus |
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243 | (16) |
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16. Altered (14)C-Deoxyglucose Incorporation in Rat Brain Following Treatment with XXX-Lipoic Acid |
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259 | (10) |
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17. Effect of XXX-Lipoic Acid on Muscle Glucose Transporters in Streptozotocin-Induced Diabetic Rats |
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269 | (14) |
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18. Lipoate Effects in an Animal Model of Insulin Resistance: The Obese Zucker Rat |
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283 | (12) |
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19. Lipoate Treatment of Toxic Polyneuropathy |
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295 | (10) |
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20. XXX-Lipoic Acid Treatment of Peripheral Nerve Disease |
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305 | (16) |
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21. Lipoate Effects on Atherogenesis |
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321 | (16) |
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| III. Medical Applications |
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337 | (128) |
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22. Human Pharmacokinetics of XXX-Lipoic Acid |
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337 | (24) |
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23. Free Radicals and the Design of Antioxidants: Implications for the Use of Lipoic Acid in Diabetes Treatment |
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361 | (12) |
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24. Thioctic Acid: A Potential Modulator of Insulin Sensitivity and Glucose Metabolism in Patients with Type II Diabetes |
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373 | (20) |
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25. Thioctic Acid Stimulates Muscle ATP Production in Patients with Type II Diabetes and Diabetic Polyneuropathy |
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393 | (14) |
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26. Treatment with XXX-Lipoic Acid in Diabetic Peripheral and Cardiac Autonomic Neuropathy |
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407 | (16) |
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27. Lipoate Prevention of Diabetic Microangiopathy |
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423 | (6) |
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28. Lipoate Prevention of Diabetic Microangiopathy |
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429 | (6) |
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29. Redox Modulation of Signal Transduction and Gene Expression in HIV Infection: The Role of the Antioxidant Lipoate |
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435 | (20) |
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30. The Effects of Lipoate on Free Radical Production by the Phagocytes from Humans and Animals Under Oxidative Stress |
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455 | (10) |
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| Index |
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465 | |
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