| Preface |
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iii | (12) |
| Contributors |
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xv | |
| I. Protein Folding In Vitro |
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1 | (70) |
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1. Folding of Monomeric Proteins In Vitro: Physicochemical and Biological Roles of the Intermediate States |
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1 | (34) |
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35 | (36) |
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| II. Protein Folding In Vivo: Early Stages |
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71 | (204) |
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3. Chaperone Interactions with Nascent and Newly Synthesized Proteins |
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71 | (24) |
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4. Structure and Properties of the 70-Kilodalton Heat-Shock Proteins |
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95 | (28) |
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5. The Hsp70 Reaction Cycle and Its Role in Protein Folding |
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123 | (28) |
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6. Substrate-Binding Specificity of the Hsp70 Family |
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151 | (18) |
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7. Major Heat-Shock Chaperones in Protein Folding and Inclusion Body Formation |
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169 | (14) |
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8. Structure and Function of the 90-kDa Stress Protein Hsp90 |
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183 | (10) |
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193 | (32) |
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10. Involvement of Hsp47 in the Folding and Processing of Procollagen in the Endoplasmic Reticulum |
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225 | (16) |
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241 | (34) |
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| III. Protein Folding In Vivo: Maturation |
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275 | (216) |
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12. Some Structural Aspects of Chaperonin-Assisted Folding by GroEL and GroES |
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275 | (26) |
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13. A Chaperonin from a Thermophilic Bacterium, Thermus thermophilus |
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301 | (30) |
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14. Protein Disulfide Isomerase |
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331 | (30) |
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15. Catalysis of Protein Folding by Prolyl Isomerases |
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361 | (30) |
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16. Assembly of Oligomers and Multisubunit Structures |
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391 | (24) |
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17. Early Events in the Biosynthesis of Secretory Pathway Proteins: Role of Molecular Chaperones |
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415 | (20) |
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18. Roles of Molecular Chaperones in Mitochondrial Protein Import |
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435 | (32) |
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19. Protein Folding Mediated by Intramolecular Chaperones |
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467 | (24) |
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| IV. Protein Folding In Vivo: Aged Proteins and Degradation |
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491 | (124) |
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20. Molecular Chaperones and Intracellular Protein Degradation with Emphasis on a Selective Lysosomal Pathway of Proteolysis |
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491 | (20) |
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21. Proteasomes: The Protein Death Machinery |
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511 | (22) |
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22. Structure and Function of Small Heat-Shock Proteins |
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533 | (44) |
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23. Aggregation and Accessory Proteins in the Pathology of Protein-Folding Diseases |
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577 | (38) |
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| Index |
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615 | |
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