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AIDS Clinical Review 2000/2001,9780824704339
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AIDS Clinical Review 2000/2001


Author(s): Volberding, Paul A.
ISBN10:  0824704339
ISBN13:  9780824704339
Format:  Hardcover
Pub. Date:  9/1/2000
Publisher(s): Informa Healthc

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SummaryTable of Contents
Univ. of California, San Francisco. Annual, single-volume update for HIV practitioners discusses important and controversial clinical issues. Editors of this volume seek to bridge the gap between journal review articles and book chapters.
Preface iii
Contributors xi
Human Immunodeficiency Virus Prevention: Applying the Lessons Learned
1(22)
Thomas J. Coates
Anke A. Ehrhardt
David D. Celentano
Intervention Strategies: Levels of Interventions
4(9)
Where are the Needs?
13(3)
What Can We Recommend Now?
16(1)
Conclusion
17(6)
References
17(6)
Novel Strategies Toward the Development of an Effective Vaccine to Prevent Human Immunodeficiency Virus Infection or Acquired Immunodeficiency Virus
23(40)
Barbara Ensoli
Aurelio Cafaro
How AIDS Vaccine Strategies Have Evolved from Sterilizing Immunity to the Control of Infection
25(4)
Live Attenuated Vaccines: Concepts to Learn
29(1)
Novel Strategies
30(13)
Conclusions and Perspectives
43(20)
References
46(17)
Pediatric Human Immunodeficiency Virus Type 1 Infection: Updates on Prevention and Management
63(22)
Ann J. Melvin
Lisa M. Frenkel
Introduction
65(1)
Maternal and Obstetrical Factors Associated with Perinatal HIV-1 Transmission
66(9)
Antiretroviral Therapy for HIV-1-Infected Children
75(2)
Summary
77(8)
References
77(8)
Risk of Human Immunodeficiency Virus Infection in Health Care Workers
85(16)
Rita Fahrner
Introduction
87(1)
Anecdotal Case Reports of Occupational HIV Infection
88(3)
Prospective Cohort Studies
91(1)
Prevention
92(2)
Management of Occupational Exposure
94(2)
HIV-Infected Health Care Workers: Risks to Patients
96(1)
Conclusion
97(4)
References
98(3)
Can Immune Responses to Human Immunodeficiency Virus Be Preserved, Enhanced, or Restored?
101(14)
Bruce D. Walker
Introduction
103(1)
Components of Protective Immunity in HIV Infection
104(2)
Why Does the Immune System Fail to Control HIV?
106(1)
Effects of Highly Active Antiretroviral Therapy (HAART) on HIV-Specific Immune Responses
106(1)
Rebuilding the Immune System in Chronic HIV Infection
107(1)
Critical Need for Immunotherapy plus HAART in Augmenting Immunity to HIV
108(1)
Approaches to Immune Enhancement in HIV Infection
109(1)
Conclusions and Future Directions
110(5)
References
111(4)
Reconstitution of Immunity Against Opportunistic Infections in the Era of Potent Antiretroviral Therapy
115(24)
Judith A. Aberg
Introduction
117(1)
PCP
118(5)
MAC
123(3)
CMV
126(3)
Toxoplasmosis
129(1)
Systemic Mycoses
130(1)
Summary
130(9)
References
131(8)
Salvage Therapy for Patients Failing their Current Antiretroviral Regimen
139(54)
Mary A. Albrecht
Background
141(3)
Defining Virologic Failure
144(1)
When to Switch Therapy
145(1)
Devising Salvage Therapy
146(4)
Salvage Therapy in Patients Failing PI-Containing Regimens: Clinical Trial Results
150(9)
Role of Intensification Strategies
159(2)
Predictors of Treatment Response
161(8)
Role of Genotypic and Phenotypic Resistance Assays in Devising Salvage Therapy
169(7)
Structured Treatment Interruptions
176(1)
Multidrug Rescue Regimens
177(2)
Conclusions
179(14)
References
180(13)
Drug Interactions of Antiretroviral Agents
193(36)
Bradley W. Kosel
Francesca Aweeka
Overview
195(2)
Interpretation of Drug Concentrations
197(1)
Interaction Types
197(1)
Inhibitor and/or Inducer
198(2)
Nucleoside Reverse Transcriptase Inhibitors
200(4)
PI Combinations
204(5)
NNRTI and PI Combinations
209(5)
Management of Non-ARV Drug Interactions
214(6)
Conclusion
220(9)
References
221(8)
Rationale for Immune-Based Therapies for Human Immunodeficiency Virus Type 1 Infection
229(34)
Michael M. Lederman
Hernan Valdez
Rationale for Immune-Based Therapies
231(2)
Host-Directed Therapies
233(4)
Cytokines and Growth Factors
237(5)
Enhancement of HIV-1 Specific Immune Responses
242(7)
Conclusion
249(14)
References
250(13)
Human Immunodeficiency Virus and Hepatitis B and C Coinfection: Pathogenic Interactions, Natural History, and Therapy
263(44)
Arthur Y. Kim
Raymond T. Chung
Bruce Polsky
Introduction
265(1)
HIV and HBV
266(4)
HIV and HCV
270(16)
Conclusion
286(21)
References
286(21)
Index 307

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