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Introduction to Molecular Biophysics,9780849300394
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Introduction to Molecular Biophysics


Edition: 1st
Author(s): Tuszynski, Jack A.
ISBN10:  0849300398
ISBN13:  9780849300394
Format:  Hardcover
Pub. Date:  2/26/2003
Publisher(s): CRC

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SummaryTable of Contents
Molecular biophysics is a rapidly growing field of research that plays an important role in elucidating the mysteries of life's molecules and their assemblies, as well as the relationship between their structure and function. Introduction to Molecular Biophysics fills a an urgent need for a text that provides students with the modern theoretical tools they need to understand life processes from a physical viewpoint. The authors use a combination of biological information with physical models and theories to provide a rigorous description of biological structures. The theme throughout Introduction to Molecular Biophysics is the hierarchical organization of all living systems starting with single cells and building up to systems and organisms. The text begins by presenting the structural, biochemical, and biophysical properties of the building blocks of all living systems, along with their functions in living cells. The authors also review the structure and function of the living cell with emphasis on its organization and functional interdependence of the subcellular structures, along with the examination of the role of diffusion processes in cell functions. Following the discussion of single cell organization and function, the text covers the biophysics of tissues, organs, organisms, and viruses. The text reviews numerous topics of relevance to the field of biophysics, ranging from peptide chains to DNA structure and function, cytoplasm, membranes, and motor proteins. In addition, since nonlinear physicists have developed new physical concepts that have been evaluated as a possible theoretical framework within which living systems can be better understood, the authors have provided three appendices that summarize the most important ideas and results involved in nonlinear physics, phase transitions, and diffusion. Introduction to Molecular Biophysics is richly illustrated and includes numerous examples, references, and experimental tools that make the book an outstanding text for upper-level and graduate students in biophysics, biology, and biochemistry.
ORIGINS AND EVOLUTION OF LIFE
Initiation
Machinery of prokaryotic cells
The Photosynthetic revolution
Origins of diploidal eukaryotic cells
Summary: Further stages of evolution
STRUCTURE OF BIOMOLECULES
Elementary building blocks
Generalized ester bonds
Directionality of chemical bonds
Weaker intratomic interactions
Hydrogen bonds and hydrophobic interactions
Amphipatic molecules in water environments
Structure of proteins
Structures of nucleic acids
DYNAMICS OF BIOMOLECULES
Diffusion
Vibration versus conformational transitions
Stochastic theory of reaction rates
Conformational transitions of proteins
Models of random walks on fractal lattices
Introduction to polymer biophysics
Cellular automata
Bioenergetics: The Davydov model
Biological coherence: The Froehlich model
Ionic currents through electrolytes
Electron conduction and tunneling
Proton transport
Interactions with electromagnetic radiation
STRUCTURE OF A BIOLOGICAL CELL
General characteristics of a cell
Membrane and membrane proteins
Ion channels and ion pumps
Cytoplasm
Cytoskeleton: The proteins participating in cytoskeletal organization
Networks, stress fibers, and tensegrity
Motor proteins and their roles in cellular processes
Centrioles, basal bodies, cilia, and flagella
Cell energetics: Chloroplasts and mitochondria
Other organelles
Nucleus: Nuclear chromatin, chromosomes, and nuclear lamina
Cell division
Cell intelligence
Biological signaling
NONEQUILIBRIUM THERMODYNAMICS AND BIOCHEMICAL REACTIONS
Second law of thermodynamics
Nonequilibrium thermodynamics
Rates of nonequilibrium thermodynamics processes
Single unimolecular chemical reaction
Bimolecular reactions: Protolysis
Redox reactions
The steady state approximation: The theory of reaction rates
Chemical mechanisms of enzymatic catalysis
Michaelis-Menten kinetics
Control of enzymatic reactions
MOLECULAR AND BIOLOGICAL MACHINES
Biological motion
Free energy transduction
Chemo-chemical machines
Biological machines as biased Maxwell's demons
Pumps and motors as chemochemical machines
Flux-force dependence
Overview of motor protein biophysics
Biochemical energy currency: ATP molecules
Assembly of microtubules
Assembly of actin filaments
Muscle contraction: Biophysical mechanisms, contractile proteins
NERVE CELLS
Anatomy of a nerve cell
Conducting properties of neurons
Action potential generation, Huxley-Hodgkin equations
Structure and function of synapse
Neural network models
TISSUE AND ORGAN BIOPHYSICS
Introduction
Anatomy and physiology of human circulatory system
Heart dynamics
Energy management in the human body
Respiration biophysics
Kidney physiology and dialysis
Muscle biophysics
Bone stiffness and strength
Vision biophysics
Sound perception biophysics
Gross features of the nervous system
Bioelectricity and biomagnetism
Immune system and its models
BIOLOGICAL SELF-REGULATION AND SELF-ORGANIZATION
Introduction
Self-organization
Homeostasis
First law of thermodynamics and living organisms
Physics of animal thermoregulation
Allometric laws in physiology
Entropy and information
Entropy reduction in living systems
Biological information
Evolutionary theories
Epilogue: Toward New Physics and New Biology
APPENDIX 1 - Random Walks and Diffusion
APPENDIX 2 - Models of Phase Transitions and Criticality
APPENDIX 3 - Foundations of Nonlinear Physics

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