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Parp As a Therapeutic Target,9780849300738
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Parp As a Therapeutic Target


Edition: 1st
Author(s): Zhang, Jie
ISBN10:  0849300738
ISBN13:  9780849300738
Format:  Hardcover
Pub. Date:  3/6/2002
Publisher(s): CRC

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SummaryTable of Contents
Provides a comprehensive understanding of how PARP works to aid in the better design of its inhibitors for therapeutic purposes. Covers clinical aspects of this drug that counteracts the damage done by free radicals.
Nervous System Functions of Poly(ADP-Ribose) Polymerase-1
1(18)
Krishna Juluri
Hyo Chol Ha
Solomon H. Snyder
Role of Poly(ADP-Ribose) Polymerase-1 in Neurologic Disorders
19(20)
Marc F. Poitras
Valina L. Dawson
Ted M. Dawson
Involvement of PARP-1 and Poly(ADP-Ribosyl)ation in the Maintenance of Genomic Stability
39(28)
Cynthia M. Simbulan-Rosenthal
Dean S. Rosenthal
Bassem H. Haddad
Danith Ly
Jie Zhang
Mark E. Smulson
Functional Testing of Human PARP in Proliferation, Endotoxic Shock, and Radiosensitivity: A Genetic Rescue Study
67(16)
Zdenko Herceg
Virginie Petrilli
Anton Wutz
Bernhard Auer
Marie-Pierre Cros
Zhao-Qi Wang
PARP Inhibitors as Neuroprotective Agents for Brain Injury
83(34)
Joel H. Greenberg
Michelle C. LaPlaca
Tracy K. McIntosh
PARP Inhibitors and Cardioprotection
117(18)
Christoph Thiemermann
Nicole Wayman
Michelle C. McDonald
Prabal Kumar Chatterjee
Neuroprotection of the Retina with 3-Aminobenzamide, a PARP Inhibitor
135(14)
Tim T. Lam
Poly(ADP-Ribose) Polymerase Inhibitors and Acute Renal Failure
149(20)
Prabal Kumar Chatterjee
Christoph Thiemermann
Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Shock and Inflammation
169(36)
Csaba Szabo
Clinical Development of the Nicotinamides and Benzamides Involving PARP as a Molecular Target
205(18)
Ronald W. Pero
Anders Olsson
Hanna Lindgren
Tomas Leanderson
Chemoprotective Effect of a Novel PARP Inhibitor
223(16)
Gyorgy Rabloczky
Laszlo Jaszlits
Gyorgy Bardos
Balazs Sumegi
Kalman Tory
Ildiko Racz
Beatrix Farkas
Attila Sandor
Zoltan Berente
Erzsebet Osz
Judit Szilvassy
Istvan Sziklai
Sandor Bernath
Peter Literati Nagy
Beneficial Effect of GPI 6150 Treatment in Multiple Animal Models of Diseases
239(18)
Jie Zhang
Protecting Effect of PARP Inhibition on Ultraviolet Light-Induced Skin Damage
257(20)
Beatrix Farkas
Balazs Sumegi
Gyorgy Rabloczky Bela Csete
Balazs Hodosi
Marta Magyarlaki
Sandor Bernath
Peter Literati Nagy
Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Diabetes Mellitus and Diabetic Vascular Dysfunction
277(44)
Jon G. Mabley
Laszlo Virag
Csaba Szabo
Therapeutic Targeting of the PARPs: Future Challenges, Future Opportunities
321(8)
Myron K. Jacobson
Elaine L. Jacobson
Index 329

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