| Foreword |
|
ix | |
| Chapter 1 The First Twenty-Five Years of p53 Research |
|
1 | (26) |
|
Harlan Robins, Gabriela Alexe, Sandra Harris and A. J. Levine |
|
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| Chapter 2 Regulation of p53 DNA Binding |
|
27 | (26) |
|
Kristine McKinney and Carol Prives |
|
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| Chapter 3 20 Years of DNA Damage Signaling to p53 |
|
53 | (20) |
|
Kevin G. McLure and Michael B. Kastan |
|
|
| Chapter 4 Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX |
|
73 | (42) |
|
Geoffrey M. Wahl, Jayne M. Stommel, Kurt Krummel and Mark Wade |
|
|
| Chapter 5 Regulation of the p53 Response by Cellular Growth and Survival Factors |
|
115 | (26) |
|
Lauren Brown and Samuel Benchimol |
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| Chapter 6 p53, Cell Cycle Arrest and Apoptosis |
|
141 | (24) |
|
Shulin Wang and Wafik S. El-Deiry |
|
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| Chapter 7 p53 Has a Direct Pro-apoptotic Action at the Mitochondria |
|
165 | (18) |
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| Chapter 8 Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor |
|
183 | (26) |
|
Lawrence A. Donehower, Dora Bocangel, Melissa Dumble and Guillermina Lozano |
|
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| Chapter 9 p53, p63, and p73: Internecine Relations? |
|
209 | (14) |
|
Frank McKeon and Annie Yang |
|
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| Chapter 10 p73, p63 and Mutant p53: Members of Protein Complexs Floating in Cancer Cells |
|
223 | (10) |
|
Olimpia Monti, Alexander Damalas, Sabrina Strano and Giovanni Blandino |
|
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| Chapter 11 p53: Gatekeeper, Caretaker or Both? |
|
233 | (22) |
|
Carlos P. Rubbi and Jo Milner |
|
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| Chapter 12 Analysis of p53 Gene Alterations in Cancer: A Critical View |
|
255 | (38) |
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| Chapter 13 Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection |
|
293 | (28) |
|
Hong Shi, Florence Le Calvez, Magali Olivier and Pierre Hainaut |
|
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| Chapter 14 Prognostic and Predictive Value of TP53 Mutations in Human Cancer |
|
321 | (18) |
|
Magali Olivier, Pierre Hainaut and Anne-Lise Børresen-Dale |
|
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| Chapter 15 p53 Links Tumor Development to Cancer Therapy |
|
339 | (14) |
|
Michael T. Hemann and Scott W. Lowe |
|
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| Chapter 16 Novel p53-Based Therapies: Strategies and Future Prospects |
|
353 | (24) |
|
Sonia Lain and David Lane |
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| Chapter 17 Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue |
|
377 | (22) |
|
Andreas C. Joerger, Assaf Friedler and Alan R. Fersht |
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| Chapter 18 Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy |
|
399 | (22) |
|
Galina Selivanova, Vladimir J.N. Bykov and Klas G. Wiman |
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| Chapter 19 Novel Approaches to p53-Based Therapy: ONYX-015 |
|
421 | (10) |
|
Frank McCormick and David A. Wood |
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| Chapter 20 p53 as Seen by an Outsider |
|
431 | (8) |
|
|
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| Index |
|
439 | |
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