| Color Plate Section Follows the List of Contributors |
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| FOREWORD Stretching Our Views of Cardiac Control |
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ix | |
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| PREFACE Cardiac Mechano-Electric Feedback: From Pipette to Patient |
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xiii | |
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Peter Kohl, Frederick Sachs, and Michael R. Franz |
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| SECTION I (Sub-Cellular) Mechanisms of Cardiac Mechano-Electric Feedback |
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1 Stretch-Activated Channels in the Heart |
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2 | (9) |
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2 Potassium-Selective Cardiac Mechanosensitive Ion Channels |
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11 | (10) |
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Amanda Jane Patel and Eric Honoré |
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3 Cell Volume-Sensitive Ion Channels and Transporters in Cardiac Myocytes |
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21 | (12) |
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4 The Mechanosensitivity of Voltage-Gated Channels May Contribute to Cardiac Mechano-Electric Feedback |
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33 | (9) |
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Catherine E. Morris and Ulrike Laitko |
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5 Membrane-Cytoskeleton Interface and Mechanosensitive Channels |
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42 | (11) |
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Thomas M. Suchyna and Frederick Sachs |
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6 The Response of Cardiac Muscle to Stretch: The Role of Calcium |
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53 | (10) |
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John Jeremy Rice and Donald M. Bers |
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7 Stretch Effects on Second Messengers and Early Gene Expression |
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63 | (9) |
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Torn Suzuki and Tsutomu Yamazaki |
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| SECTION II Effects of Mechano-Electric Feedback on Cardiac Cellular Electrophysiology |
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8 Mechanical Modulation of Sinoatrial Node Pacemaking |
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72 | (11) |
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Patricia J. Cooper and Peter Kohl |
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9 Temporal Modulation of Mechano-Electric Feedback in Cardiac Muscle |
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83 | (9) |
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10 Cardiac Fibroblasts: Origin, Organization, and Function |
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92 | (7) |
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11 Effects of Mechanical Signals on Ventricular Gap Junction Remodeling |
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99 | (9) |
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André G. Kléber and Jeffrey E. Saffitz |
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| SECTION III Experimental Manifestations of Mechano-Electric Feedback in the Heart |
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12 Regional Stretch Effects in Pathological Myocardium |
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108 | (11) |
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13 Mechanical Triggers and Facilitators of Cardiac Excitation and Arrhythmias |
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119 | (8) |
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Markus Zabel and Michael R. Franz |
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14 The Effects of Wall Stretch on Ventricular Conduction and Refractoriness in the Whole Heart |
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127 | (10) |
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Robert W. Mills, Sanjiv M. Narayan, and Andrew D. McCulloch |
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15 Ventricular Fibrillation Secondary to Nonpenetrating Chest Wall Impact (Commotio Cordis) |
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137 | (8) |
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Mark S. Link, Barry J. Maron, and N.A. Mark Estes III |
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16 Mechano-Electric Feedback in Atrial Fibrillation |
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145 | (9) |
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17 The Substrate of Atrial Fibrillation in Chronically Dilated Atria |
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154 | (10) |
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Ulrich Schotten and Maurits Allessie |
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18 Mechanical Versus Ischemic Preconditioning |
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164 | (8) |
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Michel Ovize and Karin Przyklenk |
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| SECTION IV Cardiac Mechano-Electric Feedback in Normal Physiology |
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19 Non-neural Component of Respiratory Sinus Arrhythmia |
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172 | (7) |
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20 Is the U Wave in the Electrocardiogram a Mechano-Electric Phenomenon? |
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179 | (12) |
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21 Load Dependence of Ventricular Repolarization |
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191 | (7) |
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Peter Taggart and Peter Sutton |
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22 Mechano-Electric Heterogeneity in Physiologic Function of the Heart |
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198 | (10) |
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Vladimir S. Markhasin and Olga Solovyova |
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23 Mechanical Modulation of Cardiac Function: Role of the Pericardium |
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208 | (12) |
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| SECTION V Cardiac Mechano-Electric Feedback as a Pathogenic Mechanism |
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24 Mechanically Induced Electrical Remodeling in Human Atrium |
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220 | (9) |
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Jonathan M. Kalman, Prashanthan Sanders, and Joseph B. Morton |
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25 Atrial Fibrillation and Dilated Cardiomyopathy |
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229 | (11) |
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A. John Camm and Shamil Yusuf |
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26 Natriuretic Peptide and Sudden Cardiac Death in Patients with Congestive Heart Failure |
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240 | (9) |
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Alan Maisel, Vikas Bhalla, Meenakshi A. Bhalla, and Sanjiv M. Narayan |
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27 Neurohormonal Antagonists in Relation to Sudden Death in Heart Failure |
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249 | (10) |
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28 Electro-Mechanical Remodeling in Hypertrophy |
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259 | (11) |
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Dirk W. Donker, Harry J.G.M. Crijns and Paul G.A. Volders |
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29 Sudden Death Caused by Chest Wall Trauma (Commotio Cordis) |
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270 | (7) |
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Mark S. Link, N.A. Mark Estes III, and Barry J. Maron |
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30 Volume and Pressure Overload and Ventricular Arrhythmogenesis |
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277 | (9) |
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31 Mortality from Heart Failure: Hemodynamics Versus Electrical Causes |
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286 | (9) |
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Steven N. Singh and Pamela Karasik |
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32 Wall Stress and Arrhythmogenesis in Patients with Left Ventricular Hypertrophy, Dilation, or Both |
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295 | (9) |
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Abdulhalim Salim Serafi and John Vann Jones |
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| SECTION VI Mechano-Electric Feedback as a Mechanism Involved in Therapeutic Interventions |
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33 Antiarrhythmic Effects of Acute Mechanical Stimulation |
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304 | (11) |
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Peter Kohl, Angie M. King, and Christian Boulin |
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34 Termination of Arrhythmias by Hemodynamic Unloading |
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315 | (6) |
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Peter Taggart and Peter Sutton |
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35 Mechanical Modulation of Defibrillation Efficacy by Preload Changes |
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321 | (11) |
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Harish Doppalapudi and Raymond E Ideker |
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36 Passive Ventricular Containment: A New Treatment Concept for Dilated Cardiomyopathy |
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332 | (10) |
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37 Cardiac Assist Devices: Effects on Reverse Remodeling |
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342 | (12) |
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Stefan Klotz and Daniel Burkhoff |
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38 Cardiac Resynchronization Therapy for Patients with Heart Failure with Ventricular Conduction Delay |
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354 | (11) |
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Angelo Auricchio and Andrew Kramer |
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39 Drugs Interacting with Mechano-Electric Feedback: Proarrhythmia, Remodeling, and Apoptosis |
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365 | (9) |
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Paulus Kirchhof and Gunter Breithardt |
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| SECTION VII Outlook |
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40 Evolving Concepts in Measuring Ventricular Strain in the Human Heart |
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374 | (7) |
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41 Distributions of Myocyte Stretch, Stress, and Work in Models of the Normal and Infarcted Ventricles |
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381 | (11) |
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Espen W. Remme, Marlyn P. Nash, and Peter J. Hunter |
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42 Stretch Channel Blockers: A New Class of Antiarrhythmic Drugs? |
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392 | (7) |
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Frank Bode and Michael R. Franz |
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| Epilogue Mechano-Electric Feedback: New Directions, New Tools |
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399 | (2) |
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Michael R. Franz, Frederick Sachs, and Peter Kohl |
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| Index |
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401 | |
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