Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations

U.T. Bornscheuer, R.J. Kazlauskas Hydrolases in Organic Synthesis Regio- and Stereoselective Biotransformations The most useful enzymes for synthesis are the hydrolases because of their ease of use and high stereoselectivity. Hydrolases are used commercially to produce food ingredients (e.g., aspartame, cocoa butter equivalents), agrochemical and pharmaceutical intermediates. This book surveys the stereoselective reactions of hydrolases, especially lipases, esterases and proteases. It gives researchers an overview of what has worked in the past so that researchers can get ideas on how to solve their synthetic problems. This book is intended for synthetic organic chemists who need an overview of possible reactions with hydrolases and their stereoselectivity. The book is organized first according to different synthetic problems (enantioselective reactions, regioselective reactions) and then according to the substrate structure (e.g. primary alcohols, carboxylates). It contains over a thousand chemical structures, so that the organic chemist can quickly locate reactions of interest.