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9784431702610

Lipoprotein Metabolism and Atherogenesis

by ;
  • ISBN13:

    9784431702610

  • ISBN10:

    443170261X

  • Format: Hardcover
  • Copyright: 2000-07-01
  • Publisher: Springer Verlag
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Summary

Kyoto Univ., Japan. Contains papers presented at the International Symposium on Lipoprotein Metabolism and Atherogenesis held in Kyoto, Japan on December 5-8, 1998. Focuses on the molecular approach to studying risk factors and prevention, the creation of novel animal models, and lipoprotein disorder as a cause of activation of vascular endothelial cells.

Table of Contents

Preface v
Organization of Symposium vii
Acknowledgements viii
Contributors xv
The Molecular Approach to Risk Factors and Prevention
Lipoprotein Metabolism and Atherogenesis
3(9)
J. Shepherd
C.J. Packard
Role of Lipid Concentrations and Apolipoproteins in Altering ApoB Metabolism and Promoting Coronary Events
12(7)
F.M. Sacks
Long-Term Effect of LDL-Apheresis on Familial Hypercholesterolemia Homozygotes
19(7)
A. Yamamoto
A. Kawaguchi
M. Harada-Shiba
Molecular Mechanism of Visceral Obesity
26(8)
Y. Matsuzawa
T. Funahashi
T. Nakamura
I. Shimomura
Y. Arita
Diabetes and Atherosclerosis
34(5)
S. Oikawa
T. Naito
H. Kotake
T. Toyota
The Molecular Basis of Lipoprotein Metabolism(I)
Molecular Genetics and Clinical Features of Japanese Patients with Familial Hypercholesterolemia
39(5)
H. Mabuchi
A. Nohara
J. Koizumi
K. Kajinami
Molecular Analysis of Apolipoprotein A-I and E Mutants in Japan
44(4)
J. Sasaki
Novel Mutations of the LDL Receptor Gene in Familial Hypercholesterolemia pedigrees in Hokkaido
48(3)
M. Emi
T. Hirayama
M. Tsuji
A. Hata
Preheparin Lipoprotein Lipase Mass Might Reflect the Amount of Working Lipoprotein Lipase in the Whole Body
51(3)
K. Shirai
T. Murano
H. Watanabe
Y. Miyashita
Y. Itoh
M. Totsuka
Quantitative Trait Loci (QTLs) for Serum Cholesterol Levels in the Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)
54(2)
T. Gotoda
N. Kato
Y. Yamori
Evidence of Linkage in Familial combined Hyperlipidemia to Chromosome lq21-q23
56(3)
P. Pajukanta
C. Ehnholm
M.-R. Taskinen
L. Peltonen
Molecular Analysis on the LDL Receptors in Two Patients with Homozygous Familial Hypercholesterolemia
59(3)
Y. Miyake
T. Yamamura
K. Oi
H. Hori
Common Mutation of 5, 10-Methylenetrahydrofolate Reductase Accelerates Coronary Artery Disease in Familial Hypercholesterolemia
62(3)
M. Kawashiri
K. Kajinami
A. Nohara
K. Yagi
A. Inazu
J. Koizumi
H. Mabuchi
Effect of Troglitazone on Plasma Lipid Metabolism and Lipoprotein Lipase
65(3)
J. Kobayashi
I. Nagashima
M. Hikita
H. Bujo
K. Takahashi
M. Otabe
N. Morisaki
Y. Saito
Combination of LPL Gene Exon 9 Ser447-->Ter Nonsense Mutation and Apoε2 Allele Might Contribute to Development of Hypertriglyceridemia
68(3)
T. Murano
H. Watanabe
Y. Miyashita
Y. Itoh
M. Totuka
K. Shirai
Improvement by Thiazolidinediones of Vascular Endothelial Cell Dysfunction in Diabetic Patients: A Possible New Physiological Role of PPARγ
71(3)
D. Yamada
K. Kato
S. Midorikawa
W. Satoh
S. Hashimoto
H. Satoh
K. Tsukamoto
T. Watanabe
Beneficial Effect of Gemfibrozil on LDL Chemicophysical Characteristics and Oxidizability
74(3)
H. Yoshida
M. Ayaori
T. Hisada
T. Ishikawa
F. Ohsuzu
H. Nakamura
Inhibitory Effect of HMG-CoA Reductase Inhibitors for the Development and Progression of Intimal-Medial Thickness in Carotid Artery in Type 2 Diabetes Mellitus with Hypercholesterolemia
77(3)
S. Kobori
T. Takahashi
S. Kodama
T. Takemura
T. Matsumura
M. Sakai
T. Sasahara
M. Shichiri
Plasma Phosphatidylcholine Hydroperoxide Concentrations in Normal Subjects and Patients with Hyperlipidemia
80(5)
Y. Ishigaki
S. Oikawa
M. Kinoshita
K. Hayasaka
A. Sekikawa
T. Nagashima
T. Toyota
T. Miyazawa
The Molecular Basis of Lipoprotein Metabolism (II)
Lipid Transfer Proteins and Receptors in HDL Metabolism
85(3)
A.R. Tall
X.-C. Jiang
N. Wang
T. Arai
D. Silver
PPARs and Atherosclerosis
88(8)
I.P. Torra
J.-C. Fruchart
B. Staels
Molecular Basis of Cellular Cholesterol Efflux and Regulation of Plasma HDL Level
96(8)
S. Yokoyama
M. Tsujita
S. Dohmae
Roles of Apolipoprotein E Receptors in Lipoprotein Metabolism
104(4)
T.T. Yamamoto
Y. Inagaki
R.X. Ioka
S.Z. Yoshioka
K. Magoori
M.-J. Kang
Y. Cho
A.Z. Nakano
Q. Liu
T. Fujino
D.-H. Kim
The Structure and Function of the Scavenger Receptor Class A
108(7)
T. Murakami
Y. Yamada
T. Doi
T. Hamakubo
T. Kodama
Impairment of Reverse Cholesterol Transport System and Atherosclerosis
115(9)
S. Yamashita
T. Maruyama
K. Hirano
N. Sakai
N. Nakajima
Y. Matsuzawa
ACAT Genes and Proteins in Humans
124(6)
T.Y. Chang
C. Chang
O. Lee
J. Cruz
Caveolin is Cholesterol-Binding Protein
130(7)
M. Murata
In Vivo Functions of SREBPs
137(5)
H. Shimano
N. Yamada
Molecular Characterization of Arachidonate Preferring Acyl-CoA Synthetase, ACS4
142(2)
Y.-Y. Cho
M.-J. Kang
H. Minekura
S. Ogawa
T. Fujino
T.T. Yamamoto
Molecular Characterization of Short-Chain Acyl-CoA Synthetases
144(2)
T. Fujino
H. Sato
Y. Cho
T.T. Yamamoto
Expression of the VLDL Receptor is Up-Regulated by Cell Differentiation in HL-60 Cells
146(3)
S. Takahashi
M. Kohno
S. Kosaka
K. Masamura
J. Suzuki
K. Oida
T. Yamamoto
I. Miyamori
Transcriptional Regulation of the Genes for Human HMG CoA Synthase and Squalene Synthase by SREBP and NF-Y
149(3)
J. Inoue
R. Sato
Expression of Acyl-Coenzyme A: Cholesterol Acyltransferase-1 (ACAT-1) Protein in Human Atherosclerotic Lesions and Cultured Monocytes-Macrophages
152(2)
A. Miyazaki
N. Sakashita
K.K. Maung
K. Takahashi
S. Horiuchi
C.C.Y. Chang
T.Y. Chang
Relationship Between Postprandial Triglyceride Level and Intima-Media Thickness of Carotid Artery After Troglitazone Treatment in Type 2 Diabetes
154(3)
H. Koshiyama
S. Tanaka
J. Minamikawa
K. Nakao
A New Rabbit Strain with Heritable Hypercholesterolemia and Hypertriglyceridemia
157(3)
S. Takasaki
C. Zhang
T. Ito
H. Tomoike
Turnover of Glutathione and Ascorbic Acid is Suppressed in Hyperlipidemic Rabbits
160(3)
K. Suzumura
E. Kasahara
K.-C. Chien
M. Inoue
Pravastatin, an HMG-CoA Reducatase Inhibitor, is Transported by Rat Organic Anion Transporting Polypeptide, oatp2
163(6)
T. Tokui
D. Nakai
R. Nakagomi
M. Kakyo
T. Nishio
T. Abe
H. Suzuki
Y. Sugiyama
The Search for the Link Between Lipoprotein Metabolism Disorder and Atherogenesis (I)
The Puzzling Ligands for Scavenger Receptors
169(7)
D. Steinberg
Granulocyte Macrophage Colony-Stimulating Factor is Involved in Murine Macrophage Proliferation Induced by Oxidized Low Density Lipoprotein
176(8)
T. Biwa
H. Hakamata
M. Sakai
A. Miyazaki
S. Horiuchi
Mast Cells in Atherogenesis: A Model for Studying Proteolytic Modification of Low and High Density Lipoproteins
184(9)
P.T. Kovanen
M. Lee
L. Lindstedt
K. Oorni
LOX-1, an Endothelial Receptor for Oxidized LDL-Implications for Induction of Endothelium Dysfunction in the Pathogenesis of Vascular Diseases-
193(6)
T. Sawamura
M. Kakutani
C. Mingyi
T. Masaki
Inducible Expression of Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 in Vascular Endothelial Cells and Macrophages
199(8)
N. Kume
T. Murase
H. Moriwaki
H. Kataoka
M. Minami
T. Kita
Identification and Characterization of a PDZ Domain-Containing Protein that Interacts with the HDL Receptor SR-BI
207(3)
M. Ikemoto
D. Feng
H. Arai
M. Tsujimoto
K. Inoue
Structure and Function of Human SREC (Scavenger Receptor Expressed by Endothelial Cells), A Novel Receptor for Modified LDL
210(3)
H. Adachi
M. Tsujimoto
H. Arai
K. Inoue
The Role of CD36 in Atherogenesis as a Receptor for OxLDL
213(6)
S. Nozaki
S. Yamashita
Y. Matsuzawa
Apoptosis in Atherosclerosis: Induction of Apoptosis by Oxidized Low Density Lipoprotein and Oxysterols
219(5)
K. Harada
Z. Chen
N. Yamada
S. Ishibashi
Combination Treatment with an Insulin Action Enhancer and an Inhibitor of HMG-CoA Reductase Shows a Synergistic Effect on Atherosclerosis of WHHL Rabbits
224(3)
M. Shiomi
T. Ito
T. Tsukada
Y. Tsujita
H. Horikoshi
Reduced Secretion of Tumor Necrosis Factor-α and Interleukin-1β from Monocyte-Derived Macrophages of CD36-Deficient Subjects in Response to Oxidized LDL
227(3)
M. Janabi
S. Yamashita
K. Hirano
K. Matsumoto
S. Nozaki
Y. Matsuzawa
CD36 Expression in Human Monocytic Leukemia Cell Lines: THP-1 and THP-1 Subtype, Show Different Expressions of Type I and Type II Scavenger Receptors
230(5)
R. Sugano
M. Harada-Shiba
N. Nishimura
Y. Miyake
J. An
D.X. Hui
T. Yamamura
A. Yamamoto
The Search for the Link Between Lipoprotein Metabolism Disorder and Atherogenesis (II)
Alteration of Smooth Muscle Cell Phenotype in Diabetic Vascular Wall: From the Molecular Point of View
235(8)
Y. Saito
K. Yokote
K. Tamura
M. Takemoto
T. Matsumoto
H. Ueno
S. Mori
The Vascular Nitric Oxide/Superoxide System and Atherosclerosis
243(3)
M. Yokoyama
N. Inoue
K. Hirata
S. Kawashima
Antagonistic Monoclonal Antibody Against Receptor Tyrosine Kinases: A Novel Strategy to Study the Role of Monocyte/Macrophage in Atherogenesis In Vivo
246(8)
M. Yokode
T. Murayama
H. Kataoka
T. Imabayashi
H. Yoshida
H. Sano
S. Nishikawa
S. Nishikawa
T. Kita
Rac 1 and CDC42Hs Play a Critical Role in MCP-1-Induced Chemotaxis
254(3)
H. Arai
I.F. charo
Stimulation of Mitogen-Activated Kinases by Lysophosphatidylcholine in Bovine Aortic Endothelial Cells
257(3)
H. Ozaki
K. Ishii
H. Arai
N. Kume
T. Kita
Ca2+-Dependent Activation of the 33-kDa Thrombin Receptor-Associated Kinase in Human Platelets
260(3)
M. Ido
T. Hayashi
K. Suzuki
Lysophosphatidylcholine Generates Superoxide Anios Through Activation of Phosphatidylinositol 3-Kinase in Human Neutrophils
263(3)
H. Nishioka
H. Horiuchi
H. Arai
T. Kita
PDGF Enhanced 7-Ketocholesterol-Induced Apoptosis of Vascular Smooth Muscle Cell, Accompaning with c-myc Expression
266(3)
Y. Miyashita
T. Murano
H. Watanabe
Y. Itoh
M. Totsuka
K. Shirai
Adventitia-Derived Macrophages Contribute to the Formation of Coronary Arteriosclerotic Lesions in Pigs In Vivo-Potentiating Effect of Oxidative Stress-
269(3)
K. Miyata
H. Shimokawa
A. Takeshita
Expression of CD36 in Cultured Human Aortic Smooth Muscle Cells (HASMCs)
272(3)
K. Matsumoto
K. Hirano
S. Nozaki
M. Nishida
T. Ohya
M.J. Yakub
T. Funahashi
S. Yamashita
Y. Matsuzawa
Induction of Macrophage VEGF in Response to Oxidized LDL and VEGF Accumulation in Human Atherosclerotic Lesion
275(3)
M. Kuzuya
M.A. Ramos
S. Kanda
A. Iguchi
F-1394, an ACAT Inhibitor, Inhibits Neointimal Thickening and Macrophage Accumulation After Balloon Injury in the Cholesterol-Fed Rabbit
278(3)
K. Aragane
K. Kojima
T. Kitamine
K. Fujinami
H. Kozono
K. Kano
T. Chiwata
J. Kusunoki
Y. Sekine
Key Word Index 281

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