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BRS Biochemistry, Molecular Biology, and Genetics,9780781798754

BRS Biochemistry, Molecular Biology, and Genetics

by ; ;
Edition:
5th
ISBN13:

9780781798754

ISBN10:
0781798752
Format:
Paperback
Pub. Date:
12/7/2009
Publisher(s):
Lippincott Williams & Wilkins
List Price: $49.05

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Summary

Thoroughly updated for its Fifth Edition, this popular review book is an excellent aid for USMLE Step 1 preparation and for coursework in biochemistry, molecular biology, and genetics. Chapters are written in an outline format and include pedagogical features such as bolded key words, figures, tables, algorithms, and highlighted clinical correlates. USMLE-style questions and answers follow each chapter and a comprehensive exam appears at the end of the book. A companion website includes an interactive question bank with questions from the book and the fully searchable text.

Table of Contents

Prefacep. v
Publisher's Prefacep. vii
Acknowledgmentsp. ix
Introduction: Organic Chemistry Reviewp. 1
Brief Review of Organic Chemistryp. 1
Acids, Bases, and Buffersp. 1
Carbohydrate Structurep. 4
Proteoglycans, Glycoproteins, and Glycolipidsp. 9
Amino Acidsp. 11
Lipidsp. 14
Membranesp. 16
Nucleotidesp. 18
Review Testp. 19
Protein Structure and Functionp. 23
General Aspects of Protein Structurep. 23
Examples of Medically Important Proteinsp. 28
Review Testp. 34
Enzymesp. 38
General Properties of Enzymesp. 38
Dependence of Velocity on Enzyme and Substrate Concentrations, Temperature, and pHp. 39
The Michaelis-Menten Equationp. 40
The Lineweaver-Burk Plotp. 41
Inhibitorsp. 41
Allosteric Enzymesp. 43
Regulation of Enzyme Activity by Post-Translational (Covalent) Modificationp. 44
Regulation by Protein-Protein Interactionsp. 44
Isoenzymesp. 45
Review Testp. 46
Biochemistry of Digestionp. 50
Digestion of Carbohydratesp. 50
Digestion of Dietary Triacylglycerolp. 51
Protein Digestion and Amino Acid Absorptionp. 54
Review Testp. 57
Glycolysisp. 63
General Overviewp. 63
Transport of Gulcose into cellsp. 63
Reaction of Glycolysisp. 64
Special Reactions in Red Blood Cellsp. 66
Regulatory Enzymes of Glycolysisp. 66
The Fate of Pyruvatep. 68
Generation of Adenosine Triphosphate by Glycolysisp. 69
Review Testp. 72
The Tricarboxylic Acid Cycle, Electron Transport Chain, and Oxidative Metabolismp. 77
The Tricarboxylic Acid Cyclep. 77
Electron Transport Chain and Oxidative Phosphorylationp. 85
Reactive Oxygen Speciesp. 90
Review Testp. 93
Glycogen Metabolismp. 97
Overview of Glycogen Structure and Metabolismp. 97
Glycogen Structurep. 97
Glycogen Synthesisp. 97
Glycogen Degradationp. 100
Lysosomal Degradation of Glycogenp. 101
Regulation of Glycogen Degradationp. 102
Regulation of Glycogen Synthesisp. 104
Review Testp. 105
Gluconeogenesis and the Maintenance of Blood Glucose Levelsp. 109
Overviewp. 109
Reactions of Gluconeogenesisp. 109
Maintenance of Blood Glucose Levelsp. 114
Review Testp. 119
Miscellaneous Carbohydrate Metabolismp. 123
Fructose and Galactose Metabolismp. 123
Pentose Phosphate Pathwayp. 126
Proteoglycans, Glycoproteins, and Glycolipidsp. 129
Review Testp. 133
Fatty Acid Metabolismp. 137
Fatty Acid and Triacylglycerol Synthesisp. 137
Formation of Triacylglycerol Stores in Adipose Tissuep. 141
Fatty Acid Oxidationp. 142
High Yield Comparison from Fatty Acid Synthesis and Oxidationp. 146
Review Testp. 147
Cholesterol Metabolism and Blood Lipoproteinsp. 151
Cholesterol and Bile Salt Metabolismp. 151
Blood Lipoproteinsp. 155
Review Testp. 159
Ketones and Other Lipid Derivativesp. 163
Ketone Body Synthesis and Utilizationp. 163
Phospholipid and Sphingolipid Metabolismp. 165
Metabolism of the Eicosanoidsp. 166
Synthesis of the Steroid Hormonesp. 169
Review Testp. 172
Amino Acid Metabolismp. 176
Addition and Removal of Amino Acid Nitrogenp. 176
Urea Cyclep. 177
Synthesis and Degradation of Amino Acidsp. 180
Review Testp. 187
Products Derived From Amino Acidsp. 191
Special Products Derived from Amino Acidsp. 191
Tetrahydrofolate and S-Adenosylmethionine: The One-Carbon Carriersp. 198
Review Testp. 201
Nucleotide and Porphyrin Metabolismp. 203
Purine and Pyrimidine Metabolismp. 203
Heme Metabolismp. 208
Review Testp. 211
Integrative Metabolism and Nutritionp. 215
Metabolic Fuels and Dietary Requirementsp. 215
Metabolism During the Fed or Absorptive Statep. 219
Fastingp. 221
Prolonged Fasting (Starvation)p. 224
Biochemical Functions of Tissuesp. 225
Review Testp. 229
Molecular Endocrinologyp. 233
General Mechanisms of Hormone Actionp. 233
Regulation of Hormone Levelsp. 236
Actions of Specific Hormonesp. 237
Review Testp. 247
DNA Replication and Transcriptionp. 251
Nucleic Acid Structurep. 251
Synthesis of DNA (Replication)p. 256
Synthesis of RNA (Transcription)p. 262
Review Testp. 267
RNA Translation and Protein Synthesisp. 271
Protein Synthesis (Translation of Messenger RNA)p. 271
Regulation of Protein Synthesisp. 276
Review Testp. 282
Geneticsp. 286
Chromosomesp. 286
Cell Cyclep. 286
Control of the Cell Cyclep. 288
Meiosisp. 289
Gene Dosagep. 292
Fundamentals of Mendelian Geneticsp. 293
The Punnett Squarep. 294
Modes of Inheritancep. 294
Moderators of Inheritancep. 296
Hardy-Weinberg Principlep. 296
Genetic Testingp. 297
Review Testp. 300
Biochemistry of Cancerp. 305
Oncogenesp. 305
Tumor-Suppressor Genesp. 307
Apoptosisp. 308
Mechanism of Oncogenesisp. 309
Molecular Carcinogenesisp. 311
DNA Repair and Carcinogenesisp. 313
Molecular Progression of Cancerp. 314
Molecular Markers in Cancer Biologyp. 315
Review Testp. 316
Techniques in Biochemistry, Molecular Biology, and Geneticsp. 319
Biotechnology Involving Recombinant DNAp. 319
Technology Involving Proteinsp. 329
Review Testp. 332
Comprehensive Examinationp. 336
Indexp. 361
Table of Contents provided by Ingram. All Rights Reserved.


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