9781402061905

Calcium Signalling and Disease

by ;
  • ISBN13:

    9781402061905

  • ISBN10:

    1402061900

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2007-10-31
  • Publisher: Springer Verlag

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

Purchase Benefits

  • Free Shipping On Orders Over $35!
    Your order must be $35 or more to qualify for free economy shipping. Bulk sales, PO's, Marketplace items, eBooks and apparel do not qualify for this offer.
  • Get Rewarded for Ordering Your Textbooks! Enroll Now
List Price: $347.06 Save up to $34.71
  • Rent Book $312.35
    Add to Cart Free Shipping

    TERM
    PRICE
    DUE

Supplemental Materials

What is included with this book?

  • The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
  • The Rental copy of this book is not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

Summary

This topic is a new entry in the area of cellular calcium signaling: yet, it now spans the entire area, with discoveries that cover both genetic and acquired pathologies, even offering glimpses in the direction of therapy. Cellular calcium homeostasis, and thus calcium signalling, is mainly regulated by membrane intrinsic proteins and calcium sensor proteins. Both classes may be involved in pathological processes that affect both human and animals, ranging from common and important diseases (e.g. migraine, diabetes, epilepsia, manic depression, infertility, various types of cancer, Alzheimer's disease, muscular dystrophy) to rare genetic conditions (e.g., a number of genetic heart conditions, autoimmune retinopathies, night blindness, hereditary amyloid polyneuropathy, malignant hyperthermia, cerebellar ataxia, atherothrombotic disease).Clearly, the topic has now become not only very large, but also very stimulating. Its extensive critical coverage is likely to eventually stimulate fruitful interdisciplinary discussions.

Table of Contents

Prologue.- Calcium sensor proteins and disease.- Calpains and human disease.- Gelsolin and diseases.- Guanylate cyclase activating proteins and retina disease.- Pathalogies involving the S100 proteins and RAGE.- The calcium-sensing receptor: physiology, pathophysiology and CaR-based therapeutics.- Physiological roles of the Ca2+/CaM-dependant protein kinase cascade in health and disease.- Calcium channelopathies.- TRP channels in disease.- Diseases associated with altered ryanodine receptor activity.- Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease.- Calcium pumps and disease.- The plasma membrane calcium ATPase and disease.- Diseases involving the Golgi calcium pump.- Calcium signalling and cancer cell growth.- Calcium misregulation and the pathogenesis of muscolar dystrophy.- Calcium and cell death.- Calcium and cell death: the mitochondrial connection.- Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models.- Calcium and cardiomyopathies.- Calcium signalling and calcium transport in bone disease.

Rewards Program

Write a Review