Cell Behaviour

by Lackie, J. M.; Dunn, Gary A.; Jones, G. E.; Abercombie Conference on Cell Behavior 1997 St. Catherines College

• ISBN13: 9780691009506
• ISBN10: 0691009503
• Format: Hardcover
• Copyright: 1999-04-01
• Publisher: Princeton Univ Pr

Summary

This book describes the latest molecular and genetic advances in the study of one of the most fundamental, and yet least understood, processes of life: the movement of cells.Cell locomotion lies at the basis of embryological development, wound healing, and the spread of cancers. The recent advances in identifying the molecular components of cell motility can be found in many publications, but this text uniquely provides a synthesis of the molecular and phenomenological aspects that will be required for an understanding of the controlling processes that underlie cell behavior.The book will benefit final-year students studying molecular/cell biology but it is primarily aimed at graduate research workers, in all biomolecular sciences, who need to understand the wider implications of their research. Besides cell and molecular biologists, these will include workers in oncology, vascular biology, tissue repair, and cell engineering.

Table of Contents

Dedication	vii	(1)
Acknowledgements	viii	(1)
Preface	ix	(4)
Abbreviations	xiii
Section 1: Introduction	1	(14)
1 Patterns of cellular activities based on protein sorting in cell motility, endocytosis and cytokinesis	1	(14)
G. Gerisch, M. Maniak
R. Neujahr
Section 2: Motile Responses	15	(48)
2 New depths in cell behaviour: reactions of cells to nanotopography	15	(12)
A. Curtis
C. Wilkinson
3 Self-organization of tissue-equivalents: the nature and role of contact guidance	27	(16)
R.T. Tranquillo
4 Extracellular regulation of cancer invasion: the E-cadherin-catenin and other pathways	43	(20)
V. Noe, E. Chastre
E. Bruyneel
C. Gespach
M. Mareel
Section 3: Signal Transduction	63	(84)
5 Towards a structural model of an integrin	63	(16)
M.J. Humphries
6 Integrin-mediated cell adhesion: the cytoskeletal connection	79	(22)
D.R. Critchley
M.R. Holt
S.T. Barry
H. Priddle
L. Hemmings
J. Norman
7 Wnt factors in axonal remodelling and synaptogenesis	101	(10)
P.C. Salinas
8 Rho family proteins and cell migration	111	(14)
A.J. Ridley
W.E. Allen
M. Peppelenbosch
G.E. Jones
9 Rho-like GTPases: their role in cell adhesion and invasion	125	(22)
F. Michiels
J.G. Collard
Section 4: Cytoskeletal Dynamics	147	(98)
10 Microtubule involvement in regulating cell contractility and adhesiondependent signalling: a possible mechanism for polarization of cell motility	147	(26)
M. Elbaum
A. Chausovsky
E.T. Levy
M. Shtutman
A.D. Bershadsky
11 Organization and polarity of actin filament networks in cells: implications for the mechanism of myosin-based cell motility	173	(34)
L.P. Cramer
12 Network contraction model for cell translocation and retrograde flow	207	(16)
A.B. Verkhovsky
T.M. Svitkina
G.G. Borisy
13 Centrosomes, microtubules and cell migration	223	(10)
M. Schliwa
U. Euteneuer
R. Graf
M. Ueda
14 Cell migration as a five-step cycle	233	(12)
M.P. Sheetz
D. Felsenfeld
C.G. Galbraith
D. Choquet
Section 5: Dynamics of Motility	245	(70)
15 Cytoskeletal protein mutations and cell motility in Dictyostelium	245	(22)
I. Weber
J. Niewohner
J. Faix
16 Cell crawling two decades after Abercrombie	267	(14)
T.P. Stossel
J.H. Hartwig
P.A. Janmey
D.J. Kwiatkowski
17 Using molecular genetics as a tool in understanding crawling cell locomotion in myoblasts	281	(18)
M. Peckham
C. Wells
P. Taylor-Harris
D. Coles
D. Zicha
G.A. Dunn
18 Forces in cell locomotion	299	(16)
E.L. Elson
S.F. Felder
P.Y. Jay
M.S. Kolodney
C. Pasternark
Section 6: Prospects	315	(28)
19 A dozen questions about how tissue cells crawl	315	(28)
A.K. Harris
Subject index	343