Cellular and Molecular Immunology

by Abbas, Abul K.

• ISBN13: 9781416031222
• ISBN10: 1416031227
• Edition: 6th
• Format: Paperback
• Copyright: 2007-05-23
• Publisher: Elsevier Science Health Science div

Summary

An exceptionally lucid guide to the latest immunology concepts! Through five best-selling editions, readers worldwide have appreciated this book's in-depth yet straightforward, richly illustrated approach to this complex subject. Now, sweeping updates incorporate the latest discoveries about innate immunity, the organization of lymphoid organs, and many other cutting-edge topics. Plus, online access via STUDENT CONSULT makes this an even more powerful learning resource! Clearly explains the experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levelsand the conclusions that can be drawn from those observations. Highlights the implications of immunologic science for the management of human disease, emphasizing the clinical relevance of the material. Innate immunity chapter has been increased and moved to the beginning of the book to reflect how this area is newly recognized as a critical part of immunology. New or material has been added on: - recognition of microbial products by cytoplasmic and membrane sensors - intricate organization of lymphoid tissues - functional heterogeneity of subsets of dendritic cells and lymphocytes - roles of regulatory cells and inhibitory pathways in immune regulation. Provides a wealth of excellent full-color photographs and illustrations that enable you to visualize immunologic processes quickly. Includes highlighted "take-home messages" that make it easy to review key information. Image Collection on Evolve

Table of Contents

Introduction to the Immune System
Properties and Overview of Immune Responses	p. 3
Innate Immunity	p. 19
Cells and Tissues of the Adaptive Immune System	p. 47
Recognition of Antigens
Antibodies and Antigens	p. 75
The Major Histocompatibility Complex	p. 97
Antigen Processing and Presentation to T Lymphocytes	p. 113
Antigen Receptors and Accessory Molecules of T Lymphocytes	p. 137
Maturation, Activation and Regulation of Lymphocytes
Lymphocyte Development and the Rearrangement and Expression of Antigen Receptor Genes	p. 153
Activation of T Lymphocytes	p. 189
B Cell Activation and Antibody Production	p. 215
Immunological Tolerance	p. 243
Effector Mechanisms of Immune Responses
Cytokines	p. 267
Effector Mechanisms of Cell-Mediated Immunity	p. 303
Effector Mechanisms of Humoral Immunity	p. 321
The Immune System in Defense and Disease
Immunity to Microbes	p. 351
Transplantation Immunology	p. 375
Immunity to Tumors	p. 397
Diseases Caused by Immune Responses: Hypersensitivity and Autoimmunity	p. 419
Immediate Hypersensitivity	p. 441
Congenital and Acquired Immunodeficiencies	p. 463
Glossary	p. 489
Principal Features of Selected CD Molecules	p. 519
Laboratory Techniques Commonly Used in Immunology	p. 525
Index	p. 539
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