Cerebral Microbleeds: Pathophysiology to Clinical Practice

by Edited by David J. Werring

• ISBN13: 9780521198455
• ISBN10: 0521198453
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-06-30
• Publisher: Cambridge University Press

Summary

Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.

Table of Contents

Preface

Foreword

A short note on terminology

Historical Aspects, Detection and Interpretation:

Historical overview: microaneurysms, cerebral microbleeds and intracerebral hemorrhage Varinder Singh Alg

Detection of microbleeds - physical principles, technical aspects and new developments

Susceptibility-weighted imaging

Defining and mapping cerebral microbleeds

Microbleed mimics

Mechanisms Underlying Microbleeds:

Histopathology of cerebral microbleeds

Risk factors for cerebral microbleeds

Relationship of cerebral microbleeds to other imaging findings

Microbleeds in Relation to Specific Populations, Diseases and Neurological Symptoms:

Microbleeds in healthy populations

Microbleeds in relation to cerebrovascular disease

Microbleeds in relation to hypertensive arteriopathy

Microbleeds in relation to cerebral amyloid angiopathy

Cerebral microbleeds and Alzheimer's disease

Cerebral microbleeds in relation to brain trauma

Cerebral microbleeds in CADASIL

Miscellaneous conditions associated with cerebral microbleeds David

Cerebral microbleeds and cognitive impairment David

Other clinical manifestations of cerebral microbleeds Simone M. Gregoire

Cerebral microbleeds and antithrombotic treatment Yannie

Cerebral microbleeds and thrombolysis

Index

Table of Contents provided by Publisher. All Rights Reserved.