Chemical Synthesis of Nucleoside Analogues

by Merino, Pedro

• ISBN13: 9781118007518
• ISBN10: 1118007514
• Edition: 1st
• Format: Hardcover
• Copyright: 2013-03-25
• Publisher: Wiley

Summary

Chemical Synthesis of Nucleoside Analogues examines the application of synthetic methodologies to the preparation of compounds of biological interest, including the synthesis of nucleic acids on pre-existing nucleic acid templates, assembling RNA, or DNA. This comprehensive compendium culls expert contributions that highlight the structural components of nucleosides (supported by spectral data) and their modification as well as the synthetic strategies based on chemical approaches. The text serves undergraduate students, specialists, and researchers, allowing access to a variety of compounds without forgetting the biological importance of the target compounds.

Author Biography

PEDRO MERINO, PhD, is the Director of the Department of Synthesis and Structure of Biomolecules of the Institute of Chemical Synthesis and Homogenous Catalysis at the University of Zaragoza. Dr. Merino has authored more than 200 publications, including several reviews and book chapters. His research spans asymmetric synthesis, target-oriented synthesis, organometallic chemistry, and asymmetric metal-assisted and organic catalysis. Recently, he has been investigating the use of computational chemistry to better understand reaction mechanisms.

Table of Contents

Foreword

Preface

Contributors

1. Deoxynucleoside analogues (50 pp)
Prof. Vicente Gotor, University of Oviedo. Spain

2. Nucleosides modified at the base moiety (50 pp)
Prof. Luigi Agrofoglio, University of Orleans. France

3. Acyclic Nucleosides (50 pp)
Prof. Antonin Holy, Academy of Sciences of the Czech Republic

4. Phosphorylated nucleoside analogues (40 pp)
Prof. Giovanni Romeo, University of Messina. Italy

5. Triphosphorylated nucleoside analogues (20 pp)
Prof. Chris Meier, University of Hamburg. Germany

6. Pro-nucleotides (30 pp)
Prof. Christian Perigaud, University of Montpellier 2. France

7. C-Nucleosides (50 pp)
Prof. Sergio Castillón, University Rovira i Virgili. Spain

8. Isonucleosides (30 pp)
Prof. Vasu Nair, University of Georgia. USA

9. Conformationally constrained nucleosides (40 pp)
Prof. Jacques Lebreton, University of Nantes. France

10. Spironucleosides (30 pp)
Prof. Maria Jose Camarasa, Spanish Council of Scientific Research. Spain

11. L-nucleosides (30 pp)
Dr. Daniela Perrone, University of Ferrara. Italy

12. Carbocyclic Nucleosides (60 pp)
Dr. Eric Leclerc, University of Rouen. France

13. Uncommon three-, four and six-membered nucleosides (40 pp)
Dr.  Elisabetta Groaz, University of Leuven. Belgium

14. Thionucleosides (25 pp)
Prof. L. S. Jeong, Ewha University. South Korea

15. Azanucleosides and related compounds (40 pp)
Prof. Tomas Tejero, University of Zaragoza. Spain

16. Oxathiolane and dioxolane nucleosides (30 pp)
Dr. Annalisa Guaragna, University of Napoli. Italy

17. Isoxazolidinyl nucleosides (30 pp)
Prof. Ugo Chiacchio, University of Catania. Italy

18. Nucleoside antibiotics (40 pp)
Prof. Apurba Dutta, University of Kansas. USA

19. Building blocks for peptide nucleic acids (30 pp)
Prof. Pedro Merino, University of Zaragoza. Spain

Index