The number of studies on the use of hyperthermia in combination with chemotherapeutic agents is steadily increasing. However, thermochemotherapy has not yet captured significant clinical interest. Therefore, this fourth volume in the book series Hyperthermia and Oncology deals with this topic, as the editors feel there is a significant potential for this combined modality as an adjuvant to palliative or definitive radiotherapy, or the use of chemotherapy alone to treat localized or advanced diseases. The articles in this volume deal with various aspects of chemotherapy combined with hyperthermia and will be of value and interest to researchers in this field.