Designed to meet the needs of both clinical laboratory technicians and clinical laboratory scientists, this comprehensive - yet easy to read - guide to hematology and hemostasis features cutting-edge technologies, high-quality photographs and micrographs, case studies, and convenient dual-level (basic and advanced) presentation of information. In each chapter, two levels of objectives and questions are presented, allowing content to fit specific course focus. Case studies and checkpoints in each chapter help apply and assess comprehension. Visual cross-referencing symbols throughout make finding information exceptionally easy. bull; Features: bull;Authoritative content from 24 contributors. bull;Running case studies throughout each chapter. bull;Checkpoints - questions, integrated throughout the chapter, with rationales provided. bull;High-resolution, full-color blood and bone marrow photographs throughout. bull;FREE CD-ROM contains a powerful database of images and self-assessment activities. bull;FREE integrated website - www.prenhall.com/mckenzie - compliments the text with study-guide style quiz questions and immediate tabulation of quiz results. bull;Detailed discussions of ethical issues and management issues. bull;The new technologies of molecular diagnostics, flow cytometry and cytogenetics presented here in a very easily understood manner.
I. INTRODUCTION TO HEMATOLOGY.
2. Cellular Homeostasis and Hematopoiesis.
II. THE HEMATOPOIETIC SYSTEM.
3. The Structure and Function of Hematopoietic Organs.
4. The Erythrocyte.
6. The Leukocyte.
III. HEMATOLOGY PROCEDURES.
7. Routine Hematology Procedures.
8. The Peripheral Blood Smear.
9. Bone Marrow Assessment.
IV. THE ANEMIAS.
10. Introduction to Anemia.
11. Impaired Erythrocyte Production.
14. Megaloblastic Anemia.
15. Hypoproliferative Anemia.
16. Introduction to Hemolytic Anemias.
17. Hemolytic Anemia: Membrane Defects.
18. Hemolytic Anemia: Metabolic Defects.
19. Hemolytic Anemia: Immune Mediated.
20. Hemolytic Anemia: Non-Immune Acquired Defects.
V. NONMALIGNANT DISORDERS OF LEUKOCYTES.
21. Nonmalignant Granulocyte/Monocyte Disorders.
22. Nonmalignant Lymphocyte Disorders.
VI. LABORATORY PROCEDURES USED IN DIAGNOSIS OF NEOPLASTIC HEMATOLOGIC DISORDERS.
23. Flow Cytometry.
25. Molecular Genetics of Hematologic Disorders.
VII. NEOPLASTIC HEMATOLOGIC DISORDERS.
26. Introduction to Neoplastic Hematologic Disorders.
27. Myeloproliferative Disorders.
28. Myelodysplastic Syndromes.
29. Acute Myelocytic Leukemia.
30. Acute Lymphocytic Leukemia.
31. Malignant Lymphoproliferative Disorders.
32. Hematopoietic Stem Cell Transplantation.
VIII. BODY FLUIDS.
33. Body Fluids.
34. Primary Hemostasis.
35. Secondary Hemostasis and Fibrinolysis.
36. Disorders of Primary Hemostasis.
37. Disorders of Secondary Hemostasis.
39. Laboratory Testing in Coagulation.
X. OTHER HEMATOLOGY PROCEDURES AND TOPICS.
40. Special Hematology Procedures.
41. Automation in Hematology/Hemostasis.
42. Quality Assurance and Safety.
Clinical Laboratory Hematology is a comprehensive, yet easy-to-read text of hematology and hemostasis written for students at all levels in clinical laboratory science programs, including clinical laboratory technicians, CLT (medical laboratory technicians, NET), and clinical laboratory scientists, CIS (medical technologists, MT). Other health professional students and practitioners may also benefit from this book, including pathology residents, physician assistants, and nurse practitioners. This text replaces Textbook of Hematology published by Lea & Febiger in 1988 and by Williams & Wilkins in 1996. However this text should be considered as a brand new publication because of its wide variety of changes and enhancements. Included among these changes are the following: we have assembled an extensive team of authoritative contributing authors to write chapters on specialized subjects within their respective fields of expertise; we have developed a striking design that will be conducive to today's visually oriented student; we have developed an exciting set of learning features that will help readers grasp the content more easily; we have developed a book-specific online study guide (wwwprenhall.com/mckenzie); and finally, we have packaged the text with a free student version of the Chronolab CD-ROM photomicrograph atlas. ORGANIZATION OF THE BOOK Understanding hematologic/hemostatic diseases is dependent on a thorough knowledge and understanding of normal processes. Thus, the book begins with a section on normal hematopoiesis and progresses through anemias, nonmalignant and malignant leukocyte disorders. Hemostasis adheres to a similar format with normal hemostasis functions discussed first, followed by abnormalities in hemostasis. The text is divided into sections and maybe studied by section or chapter sequence. This gives the instructor flexibility td fit the book to their specific course design. The first two sections cover an introduction to hematology and normal hematopoiesis. This includes a discussion of the cell morphology, cell cycle, and its regulation. The section includes a discussion on oncogenes emphasizing the concept that neoplasms are the result of mutations in normal genes that control cell proliferation and development. This concept is further discussed in the introduction to hematopoietic neoplasms. The third section, includes procedures that are routine and performed in most laboratories. These are included at the beginning of the book so the students will have basic laboratory test information as they proceed through the subsequent chapters on hematopoietic disorders which focus on laboratory diagnostic protocols. The next sections cover the hematopoietic disorders and special laboratory procedures. The fourth section includes the anemias and begins with an introduction to anemia chapter. The fifth section is nonmalignant disorders of the leukocytes. The sixth section includes a discussion of special laboratory procedures that are useful in diagnosis and classification of hematopoietic neoplasms: flow cytometry, cytogenetics, and molecular diagnostics. This section may be studied before or after the seventh section on neoplastic hematopoietic disorders, depending on the reader's knowledge level of the neoplasms. If this is the reader's first exposure to the neoplasms, it may be better to cover section 7 before section 6. Alternatively, sections 6 and 7 can be integrated and studied together. Section 8 is a study of body fluids. Body fluid analysis is often a function of the hematology laboratory, since analysis includes cell counts and review of cell morphology. As much of the analysis includes identification of cells and differentiation of malignant cells from reactive or normal cells, this section has many microphotographs. Section 9 is a study of hemostasis. It begins with a study of normal hemostasis processes and proceeds to abnormalities that are asso