Clinical Magnetoencephalography and Magnetic Source Imaging

by Andrew C. Papanicolaou

• ISBN13: 9780521873758
• ISBN10: 0521873754
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-09-14
• Publisher: Cambridge University Press

Summary

This is the first volume to explore the field of clinical magnetoencephalography (MEG) and magnetic source imaging (MSI), the techniques measuring the magnetic fields generated by neuronal activity in the brain. Describing the empirical knowledge gained during the last two decades, this book will serve as a basis for the training of clinicians and scientists entering this new and exciting field. The book covers the methods for recording MEG and performing MSI in a clinical setting and includes practical examples of data collection and analysis. It explains why MEG should be used in the evaluation and treatment of patients being considered for epilepsy surgery, concluding with a section describing the potential for future applications of these methods. This is essential reading for graduate students in clinical neuroscience, residents in neurology and psychiatry, neuroradiology and neurosurgery, specialists in neurophysiology and epilepsy, and clinicians in a wide range of related brain sciences.

Author Biography

Andrew C. Papanicolaou is Professor, Department of Pediatrics and Departments of Neurology and Neurosurgery, the University of Texas Medical School at Houston, Houston, Texas, USA.

Table of Contents

Contributors	p. viii
Preface	p. xi
The method
Basic concepts	p. 3
The nature and origin of magnetic signals	p. 7
Recording the magnetic flux	p. 13
Overview of MSI using the single equivalent current dipole (ECD) model as an example	p. 23
The fundamental problems of MSI	p. 26
Head models	p. 29
Source models-discrete source models	p. 34
Source models-distributed source models	p. 40
Source models-beamformers	p. 44
Pragmatic features of the clinical use of MEG/MSI	p. 47
References	p. 51
Spontaneous brain activity
MEG recordings of spontaneous brain activity - general considerations	p. 59
Normal spontaneous MEG-frequently encountered artifacts	p. 63
Spontaneous MEG morphology	p. 68
Abnormal spontaneous MEG	p. 75
Contributions of MEG to the surgical management of epilepsy - general considerations	p. 83
MEG investigations in lesional epilepsies	p. 88
MEG investigations in nonlesional epilepsies	p. 90
Pediatric nonlesional epilepsy surgery	p. 92
References	p. 102
Evoked magnetic fields
Recording evoked magnetic fields (EMFs)	p. 111
Somatosensory evoked fields (SEFs)	p. 118
Movement-related magnetic fields (MRFs) - motor evoked fields (MEFs)	p. 128
Auditory evoked magnetic fields (AEFs)	p. 134
Visual evoked magnetic fields (VEFs)	p. 138
Language-related brain magnetic fields (LRFs)	p. 144
Alternative techniques for evoked magnetic field data-future directions	p. 157
References	p. 159
Postscript: Future applications of clinical MEG
Overview	p. 173
Normal aging and neurodegenerative disorders	p. 174
Neurodevelopmental disorders	p. 178
Psychiatric disorders	p. 183
Neurological disorders	p. 186
Functional reorganization	p. 190
References	p. 192
Index	p. 200
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