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This is the 4th edition with a publication date of 1/28/2010.
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Formerly "Clinical Pharmacokinetics: Concepts and Clinical Applications, " this fully updated Fourth Edition has been retitled "Pharmacokinetics and Pharmacodynamics: Concepts and Clinical Applications" to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.
Table of Contents
|Nonproprietary and Brand Names of Drugs in Text and Illustrations||p. xiii|
|Definition of Symbols||p. xix|
|Therapeutic Relevance||p. 3|
|Fundamental Concepts and Terminology||p. 17|
|Exposure and Response after a Single Dose|
|Kinetics Following an Intravenous Bolus Dose||p. 49|
|Membranes and Distribution||p. 73|
|Kinetics Following an Extravascular Dose||p. 159|
|Response Following a Single Dose||p. 217|
|Therapeutic Window||p. 245|
|Constant-Rate Input||p. 259|
|Multiple-Dose Regimens||p. 293|
|Age, Weight, and Gender||p. 373|
|Drug Interactions||p. 483|
|Initiating and Managing Therapy||p. 527|
|Distribution Kinetics||p. 561|
|Metabolites and Drug Response||p. 603|
|Protein Drugs||p. 633|
|Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data||p. 663|
|Assessment of AUC||p. 687|
|Ionization and the pH Partition Hypothesis||p. 691|
|Distribution of Drugs Extensively Bound to Plasma Proteins||p. 695|
|Plasma-to-Blood Concentration Ratio||p. 703|
|Well-stirred Model of Hepatic Clearance||p. 705|
|Absorption Kinetics||p. 709|
|Wagner-Nelson Method||p. 713|
|Mean Residence Time||p. 717|
|Amount of Drug in Body on Accumulation to Plateau||p. 723|
|Answers to Study Problems||p. 727|
|Table of Contents provided by Ingram. All Rights Reserved.|