(0) items

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
Clinical Pharmacokinetics and Pharmacodynamics Concepts and Applications,9780781750097
This item qualifies for

Your order must be $59 or more, you must select US Postal Service Shipping as your shipping preference, and the "Group my items into as few shipments as possible" option when you place your order.

Bulk sales, PO's, Marketplace Items, eBooks, Apparel, and DVDs not included.

Clinical Pharmacokinetics and Pharmacodynamics Concepts and Applications



by ;
Pub. Date:
List Price: $102.39

Rent Textbook


Buy New Textbook

Usually Ships in 3-5 Business Days

Used Textbook

We're Sorry
Sold Out


We're Sorry
Not Available

More New and Used
from Private Sellers
Starting at $31.33

Questions About This Book?

Why should I rent this book?

Renting is easy, fast, and cheap! Renting from can save you hundreds of dollars compared to the cost of new or used books each semester. At the end of the semester, simply ship the book back to us with a free UPS shipping label! No need to worry about selling it back.

How do rental returns work?

Returning books is as easy as possible. As your rental due date approaches, we will email you several courtesy reminders. When you are ready to return, you can print a free UPS shipping label from our website at any time. Then, just return the book to your UPS driver or any staffed UPS location. You can even use the same box we shipped it in!

What version or edition is this?

This is the 4th edition with a publication date of 1/28/2010.

What is included with this book?

  • The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any CDs, lab manuals, study guides, etc.
  • The Rental copy of this book is not guaranteed to include any supplemental materials. You may receive a brand new copy, but typically, only the book itself.

  • Clinical Pharmacokinetics Concepts and Applications
    Clinical Pharmacokinetics Concepts and Applications


Formerly "Clinical Pharmacokinetics: Concepts and Clinical Applications, " this fully updated Fourth Edition has been retitled "Pharmacokinetics and Pharmacodynamics: Concepts and Clinical Applications" to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

Table of Contents

Prefacep. ix
Nonproprietary and Brand Names of Drugs in Text and Illustrationsp. xiii
Definition of Symbolsp. xix
Basic Considerations
Therapeutic Relevancep. 3
Fundamental Concepts and Terminologyp. 17
Exposure and Response after a Single Dose
Kinetics Following an Intravenous Bolus Dosep. 49
Membranes and Distributionp. 73
Eliminationp. 111
Kinetics Following an Extravascular Dosep. 159
Absorptionp. 183
Response Following a Single Dosep. 217
Therapeutic Regimens
Therapeutic Windowp. 245
Constant-Rate Inputp. 259
Multiple-Dose Regimensp. 293
Variabilityp. 333
Geneticsp. 357
Age, Weight, and Genderp. 373
Diseasep. 403
Nonlinearitiesp. 445
Drug Interactionsp. 483
Initiating and Managing Therapyp. 527
Supplemental Topics
Distribution Kineticsp. 561
Metabolites and Drug Responsep. 603
Protein Drugsp. 633
Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Datap. 663
Assessment of AUCp. 687
Ionization and the pH Partition Hypothesisp. 691
Distribution of Drugs Extensively Bound to Plasma Proteinsp. 695
Plasma-to-Blood Concentration Ratiop. 703
Well-stirred Model of Hepatic Clearancep. 705
Absorption Kineticsp. 709
Wagner-Nelson Methodp. 713
Mean Residence Timep. 717
Amount of Drug in Body on Accumulation to Plateaup. 723
Answers to Study Problemsp. 727
Indexp. 819
Table of Contents provided by Ingram. All Rights Reserved.

Please wait while the item is added to your cart...